Antibiotcs

Penicillin Allergy Linked to MRSA, <i>C. Difficile</i> Risk

Penicillin Allergy Linked to MRSA, C. Difficile Risk

There is a correlation for documented penicillin allergy with increased risk of MRSA and C diff, which is mediated by increased use of β-lactam alternative antibiotics.

Macrolides for Asthma Management: An Updated Review

Macrolides for Asthma Management: An Updated Review

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While macrolides had no direct effect on lung function, their use significantly improved asthma control and quality of life in patients with asthma.

Antibiotic Use During Pregnancy May Increase Risk for Childhood Asthma

Antibiotic Use During Pregnancy May Increase Risk for Childhood Asthma

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Researchers examined the association of timing, frequency, and class of antibiotic use during pregnancy on the development of childhood asthma.

Better UTI resolution with 5-day nitrofurantoin over single-dose fosfomycin

In this randomized controlled trial, women with uncomplicated urinary tract infections receiving 5-days of nitrofurantoin experienced increased clinical and microbiologic resolution at 28 days compared to single-dose fosfomycin.

Duration of Antibiotics Often Exceeds Guidelines for Sinusitis

Duration of Antibiotics Often Exceeds Guidelines for Sinusitis

When antibiotics are indicated for the treatment of acute bacterial sinusitis, the Infectious Diseases Society of America evidence-based clinical practice guidelines recommend 5 to 7 days of therapy for patients with a low risk of antibiotic resistance who have a favorable response to initial therapy.

Azithromycin Timing Not Associated With Childhood Mycoplasma Pneumonia Outcomes

Azithromycin Timing Not Associated With Childhood Mycoplasma Pneumonia Outcomes

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Researchers assessed the timing of azithromycin administration for pediatric community-acquired pneumonia to determine its effectiveness in the setting of macrolide resistance.

Standard-Dose vs Low-Dose Azithromycin for Treatment of Yaws

Standard-Dose vs Low-Dose Azithromycin for Treatment of Yaws

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Low-dose azithromycin did not meet the prespecified noninferiority margin compared with standard-dose azithromycin in achieving clinical and serological cure in PCR-confirmed active yaws.

Meropenem-vaborbactam noninferior to piperacillin-tazobactam for complicated urinary tract infections: The TANGO I trial

In this randomized controlled trial, meropenem-vaborbactam was found to be noninferior to piperacillin-tazobactam for treating complicated urinary tract infections.

Vegetation size greater than 10 mm associated with increased risk of mortality in infective endocarditis

In this systematic review and meta-analysis, patients with infective endocardititis with vegetations greater than 10mm in size had significantly increased risk of systemic embolism and mortality.

Antibiotics Frequently Prescribed for Suspected UTI in Nursing Home Residents

Antibiotics Frequently Prescribed for Suspected UTI in Nursing Home Residents

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Five factors were found to be significantly associated with UTI antibiotic use in order of decreasing association: presence of urinary catheter, urinary frequency, fever, new-onset hypotension, and confusion.

FDA Announces New Website to Help Clinicians Make Appropriate Antibiotic Choices

FDA Announces New Website to Help Clinicians Make Appropriate Antibiotic Choices

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The FDA announced a new website that provides direct access to information about appropriate antibiotic choices.

Inpatient High-Risk Antibiotic Use Increases Subsequent Risk of Sepsis

Inpatient High-Risk Antibiotic Use Increases Subsequent Risk of Sepsis

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A study evaluated the association between high-risk antibiotic exposure during hospitalization and subsequent sepsis risk.

Trimethoprim-Sulfamethoxazole Effective Regardless of Abscess Size

Trimethoprim-Sulfamethoxazole Effective Regardless of Abscess Size

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Trimethoprim-sulfamethoxazole appears to improve cure rates after incision and drainage of MRSA abscesses regardless of patient characteristics.

Diclofenac Inferior to Norfloxacin for UTI Symptom Relief

Diclofenac Inferior to Norfloxacin for UTI Symptom Relief

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NSAIDs were found to be inferior to antibiotics for symptom relief of uncomplicated urinary tract infection.

UTI Rate Drops in Infants on Long IV Therapy Without Increase in Readmission

UTI Rate Drops in Infants on Long IV Therapy Without Increase in Readmission

Rate of infants with a UTI who received 4 or more days of intravenous antibiotics decreased from 2005 to 2015.

Fixed-Dose Meropenem-Vaborbactam Available for Complicated UTI, Pyelonephritis

Fixed-Dose Meropenem-Vaborbactam Available for Complicated UTI, Pyelonephritis

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Vabomere is now available for the treatment of adults (≥18 years old) with complicated urinary tract infections.

Strategies for Preventing Antibiotic Resistance in Acne

Strategies for Preventing Antibiotic Resistance in Acne

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Physicians can help avoid contributing to antibiotic resistance by recognizing and using appropriate alternative treatments, and having a strategy so that patients are not on antibiotics for a long period of time.

Infant Gut Microbiome Altered by Maternal Antibiotic Use

Infant Gut Microbiome Altered by Maternal Antibiotic Use

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Mothers' use of antibiotics affects infant gut composition up to a month later.

Delafloxacin Shows High Response Rates in Fluoroquinolone-resistant <i>S aureus</i>

Delafloxacin Shows High Response Rates in Fluoroquinolone-resistant S aureus

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New data confirms delafloxacin shows high response rates against MRSA.

Tympanogram Results May Guide Appropriate Use of Abx in Acute Otitis Media

Tympanogram Results May Guide Appropriate Use of Abx in Acute Otitis Media

Older age and peaked tympanogram are associated with reduced risk of treatment failure in young children with acute otitis media.

Guaifenesin/Pseudoephedrine May Reduce Antibiotic Rx for Acute URTI

Guaifenesin/Pseudoephedrine May Reduce Antibiotic Rx for Acute URTI

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A 'wait-and-see' approach may reduce the number of inappropriate antibiotic prescriptions for acute upper respiratory tract infections.

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