Antibiotic Stewardship

The Misuse of Antibiotics in Acute Pancreatitis Appears Widespread

The Misuse of Antibiotics in Acute Pancreatitis Appears Widespread

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The inappropriate use of antibiotics as prophylaxis and treatment in acute pancreatitis is common, highlighting the efforts required for antibiotic stewardship.

Prophylactic Antibiotics May Not Be Helpful After Acute Stroke

Prophylactic Antibiotics May Not Be Helpful After Acute Stroke

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In acute ischemic or hemorrhagic stroke, prophylactic antibiotics reduce the overall infection rate, but do not reduce the risk for pneumonia, death, or dependency.

Prescribing Antibiotics Shortens Telemedicine Visits for Respiratory Tract Infections

Prescribing Antibiotics Shortens Telemedicine Visits for Respiratory Tract Infections

These findings may highlight physician difficulty explaining to patients why antibiotics are not required.

Pediatric Phase 1 Trial Shows Ceftolozane/Tazobactam Is Safe,Tolerable

Pediatric Phase 1 Trial Shows Ceftolozane/Tazobactam Is Safe,Tolerable

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Single doses of ceftolozane and tazobactam were well tolerated in children with gram-negative bacterial infections and no safety concerns were identified.

Initial Antibiotic Alternative for Uncomplicated Appendicitis

Initial Antibiotic Alternative for Uncomplicated Appendicitis

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The study included 530 patients, aged 18 to 60 years, with computed tomography-confirmed uncomplicated acute appendicitis.

High Rate of ED Visits for Children Linked With Antibiotic Adverse Effects

High Rate of ED Visits for Children Linked With Antibiotic Adverse Effects

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Many antibiotic adverse drug events led to emergency department visits, particularly among young children, highlighting a need for better communication regarding the risks of overprescribing.

Penicillin Allergies: Commonly Reported but Rarely Accurate

Penicillin Allergies: Commonly Reported but Rarely Accurate

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As infections from drug-resistant microbes continue to rise, the development of new antibiotics has declined since the golden age of antibiotic discovery in the mid-20th century.

ASM Microbe 2018 Update: Preserving Gram-Negative Antibiotics Through Better Diagnostics

ASM Microbe 2018 Update: Preserving Gram-Negative Antibiotics Through Better Diagnostics

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Neil Clancy, MD, from the VA Pittsburgh Health Care System, shares highlights from ASM Microbe 2018.

Evaluation of Appropriateness of Ceftriaxone Use in the Emergency Department

Evaluation of Appropriateness of Ceftriaxone Use in the Emergency Department

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Alternative antibiotics with a lower ecological impact were suggested for 55.2% of relevant ceftriaxone prescriptions in a university hospital emergency department setting during 2016.

Benefits of Early Azithromycin Therapy in Children With Respiratory Infections

Benefits of Early Azithromycin Therapy in Children With Respiratory Infections

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A study recently published in the Journal of Antimicrobial Chemotherapy shows the clinical benefits of early target attainment of azithromycin therapy when treating children with lower respiratory tract infections.

High Dose Pivmecillinam Effective for UTIs Caused by Resistant <i>Escherichia coli</i>

High Dose Pivmecillinam Effective for UTIs Caused by Resistant Escherichia coli

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Pivmecillinam treatment for community-acquired urinary tract infections (UTIs) caused by ESBL-producing Escherichia coli is a reasonable option.

Antibiotics Often Unnecessary for Sacral Pressure Ulcers Complicated by Osteomyelitis

Antibiotics Often Unnecessary for Sacral Pressure Ulcers Complicated by Osteomyelitis

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A systematic literature review, published in Clinical Infectious Diseases, found no evidence supporting a benefit to antibacterial therapy for osteomyelitis in patients with stage IV sacral pressure ulcers.

Penicillin Allergy Linked to MRSA, <i>C. Difficile</i> Risk

Penicillin Allergy Linked to MRSA, C. Difficile Risk

There is a correlation for documented penicillin allergy with increased risk of MRSA and C diff, which is mediated by increased use of β-lactam alternative antibiotics.

48-Hour Automatic Stop Order Effectively Decreased NICU Antibiotic Doses

48-Hour Automatic Stop Order Effectively Decreased NICU Antibiotic Doses

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A 48-hour automatic stop order for antibiotics embedded within a NICU admission order set effectively reduced antibiotic use.

Resistant <i>A Baumannii</i> Rose in Children From 1999 to 2012

Resistant A Baumannii Rose in Children From 1999 to 2012

Between 1999 and 2012, Acinetobacter baumannii antibiotic resistance increased in children.

Increased Need for Antibiotic Stewardship in Outpatient Settings

Increased Need for Antibiotic Stewardship in Outpatient Settings

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A review summarizes outpatient prescription practices and identifies factors that may influence physician prescribing behaviors.

Improvements Needed in Antibiotic Stewardship in the Neonatal Setting

Improvements Needed in Antibiotic Stewardship in the Neonatal Setting

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Early antibiotic use was examined among very low birth weight infants across hospitals in the United States.

Rapid Diagnostics Reduce Time to Optimal Antimicrobial Therapy in Children

Rapid Diagnostics Reduce Time to Optimal Antimicrobial Therapy in Children

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Time to optimal antimicrobial therapy for positive blood cultures was assessed in a pediatric population.

Empirical Use of Antibiotics for Resistant Infections Not Associated With Survival

Empirical Use of Antibiotics for Resistant Infections Not Associated With Survival

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Researchers found no association between starting colistin before final culture results and survival at 14 and 28 days.

Macrolides for Asthma Management: An Updated Review

Macrolides for Asthma Management: An Updated Review

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While macrolides had no direct effect on lung function, their use significantly improved asthma control and quality of life in patients with asthma.

Antibiotic Use During Pregnancy May Increase Risk for Childhood Asthma

Antibiotic Use During Pregnancy May Increase Risk for Childhood Asthma

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Researchers examined the association of timing, frequency, and class of antibiotic use during pregnancy on the development of childhood asthma.

Pharmacists Play Role in Cutting Hospital-Acquired Infections

Pharmacists Play Role in Cutting Hospital-Acquired Infections

Pharmacists are increasingly becoming involved in antibiotic surveillance, including e-surveillance methods; formulation of antibiotic-use policies; and day-to-day control of problematic antibiotic use.

Combating Medically Important Antibiotic Use in Food-Producing Animals

Combating Medically Important Antibiotic Use in Food-Producing Animals

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The new WHO guidelines restricts antibiotic use in animals for purposes of growth promotion as well as avoidance of use for disease prevention.

No Benefit From Prophylactic Antimicrobials in Aspiration Pneumonitis

No Benefit From Prophylactic Antimicrobials in Aspiration Pneumonitis

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Use of prophylactic antimicrobial therapy was not associated with a reduction in mortality or transfer to critical care compared with patients managed with supportive care only.

Antibiotic Rotation in ICU Does Not Reduce Prevalence of Antibiotic-Resistant Bacteria

Antibiotic Rotation in ICU Does Not Reduce Prevalence of Antibiotic-Resistant Bacteria

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Findings from the study did not provide evidence that antibiotic mixing, compared with antibiotic cycling with 6-week cycling periods reduced the prevalence of carriage with antibiotic-resistant, Gram-negative bacteria in the ICU.

Antibiotic Stewardship: Role of MRSA Nasal Screening

Antibiotic Stewardship: Role of MRSA Nasal Screening

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MRSA nares screening can be a stewardship tool to streamline empiric antibiotic therapy among those not nares colonized with MRSA.

Characteristics Associated With Inappropriate Antibiotic Prescribing

Characteristics Associated With Inappropriate Antibiotic Prescribing

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Investigators identified patient, provider, and practice characteristics associated with antibiotic prescribing in an attempt to determine factors contributing to inappropriate antimicrobial use.

How Often Do Patients Select Antibiotics Over Surgery for Acute Appendicitis?

How Often Do Patients Select Antibiotics Over Surgery for Acute Appendicitis?

Although most patients would choose surgical intervention for treatment of acute uncomplicated appendicitis, some would opt for antibiotics alone.

Prolonged Antibiotic Prophylaxis May Increase CDI Risk After Cardiac Surgery

Prolonged Antibiotic Prophylaxis May Increase CDI Risk After Cardiac Surgery

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Readmissions for CDI occurred close to hospital discharge, consistent with the CDC's surveillance study findings.

Antibiotics, Mechanical Bowel Preparation Associated With Reduced SSIs

Antibiotics, Mechanical Bowel Preparation Associated With Reduced SSIs

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Oral antibiotics combined with mechanical bowel preparation should be considered for all patients undergoing left-sided colorectal cancer resections.

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