antibiotics

Eravacycline Approved for the Treatment of Complicated Intra-Abdominal Infections

Eravacycline Approved for the Treatment of Complicated Intra-Abdominal Infections

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Eravacycline was well-tolerated in clinical trials and achieved high cure rates in patients with Gram-negative pathogens (including resistant strains).

Therapeutic Algorithm May Guide Empiric Therapy in Pneumonia

Therapeutic Algorithm May Guide Empiric Therapy in Pneumonia

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An algorithm based on risk factors for resistant pathogens and illness severity can simplify pneumonia treatment, improve the accuracy of empiric therapy, reduce mortality, and help avoid overusing broad spectrum therapy in some patients.

New Designation for Some Gram-Negative Bacteremia Increases Treatment Options

New Designation for Some Gram-Negative Bacteremia Increases Treatment Options

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Nonsusceptibility to first-line antibiotics is associated with decreased survival in gram-negative bloodstream infections.

FDA Warns Against Long-Term Azithromycin Use for Some

FDA Warns Against Long-Term Azithromycin Use for Some

The FDA is warning patients with cancers of the blood or lymph nodes who undergo a donor stem cell transplant not to take azithromycin,

Ampicillin Plus Ceftriaxone: An Effective Alternative for <i>E faecalis</i> Infective Endocarditis

Ampicillin Plus Ceftriaxone: An Effective Alternative for E faecalis Infective Endocarditis

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Ampicillin plus ceftriaxone was an effective treatment for penicillin-susceptible Enterococcus faecalis infective endocarditis compared with ampicillin plus gentamicin.

Inappropriate Antibiotic Prescriptions Highest Among Urgent Care Facilities

Inappropriate Antibiotic Prescriptions Highest Among Urgent Care Facilities

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Inappropriate antibiotic prescriptions were highest among urgent care facilities (45.7%), with emergency departments (24.6%), medical offices (17.0%), and retail clinics (14.4%) following.

Ciprofloxacin May Increase Likelihood of Aortic Dissection, Rupture

Ciprofloxacin May Increase Likelihood of Aortic Dissection, Rupture

In a mouse model of moderate, sporadic aortic aneurysm and dissection (AAD), ciprofloxacin increases susceptibility to aortic dissection and rupture.

Antibiotic Selection Pressure Causally Linked to Macrolide Resistome

Antibiotic Selection Pressure Causally Linked to Macrolide Resistome

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Communities randomly assigned to less frequent antibiotic use had significantly lower prevalence of genetic antibiotic resistance determinants.

No Reduction in Antibiotic Use With Procalcitonin-Guided Therapy in the ED

No Reduction in Antibiotic Use With Procalcitonin-Guided Therapy in the ED

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Procalcitonin-guided therapy did not reduce the number of antibiotic prescriptions among patients presenting to the ED with fever.

Generic Quality Indicators Developed for Responsible Antibiotic Usage

Generic Quality Indicators Developed for Responsible Antibiotic Usage

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A study was conducted with a goal of developing a set of generic quality indicators for the safe and appropriate use of antibiotic agents.

Ibuprofen Inferior to Pivmecillinam for Uncomplicated UTI in Women

Ibuprofen Inferior to Pivmecillinam for Uncomplicated UTI in Women

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A study evaluated whether uncomplicated UTIs in women could be treated without antibiotics.

Empirical Use of Antibiotics for Resistant Infections Not Associated With Survival

Empirical Use of Antibiotics for Resistant Infections Not Associated With Survival

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Researchers found no association between starting colistin before final culture results and survival at 14 and 28 days.

Removing Low-Risk Penicillin Allergy Label Leads to Healthcare Cost Savings

Removing Low-Risk Penicillin Allergy Label Leads to Healthcare Cost Savings

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Children deemed low risk who were tested for penicillin allergy tolerated the medication within the following year without serious adverse or allergic reactions.

Kidney Stones Linked to Oral Antibiotics

Kidney Stones Linked to Oral Antibiotics

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Use of certain antibiotics may be contributing to the rise of kidney stones among children and adults.

IV Combo Antibiotic Recalled Due to Potential for Decreased Potency

IV Combo Antibiotic Recalled Due to Potential for Decreased Potency

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The 36 recalled lots were manufactured by Hospira and marketed by Apotex.

Less Antibiotic Use Lowers Prevalence of Genetic Antibiotic Resistance Determinants

Less Antibiotic Use Lowers Prevalence of Genetic Antibiotic Resistance Determinants

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Reducing levels of antibiotic consumption in a population is an effective method for reducing the community prevalence of antibiotic resistance.

UTI Treatment Success in Women Greater With Nitrofurantoin vs Fosfomycin

UTI Treatment Success in Women Greater With Nitrofurantoin vs Fosfomycin

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Five-day nitrofurantoin may be a better alternative than single-dose fosfomycin for treating uncomplicated UTI in women.

Antibiotic Cycling, Mixing Does Not Prevent Gram-Negative Antibiotic Resistance

Antibiotic Cycling, Mixing Does Not Prevent Gram-Negative Antibiotic Resistance

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Findings do not provide evidence that antibiotic mixing, compared with antibiotic cycling with 6-week cycling periods, with third-generation or fourth-generation cephalosporins, piperacillin-tazobactam, and carbapenems reduces the prevalence of carriage with antibiotic-resistant, Gram-negative bacteria in the ICU.

How Important Is the Timing of Antibiotics for Surviving Sepsis?

How Important Is the Timing of Antibiotics for Surviving Sepsis?

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Early antibiotic administration in treating infection has evident biological plausibility, however, time-sensitivity to outcomes appears to be most relevant in septic shock.

Critical Need to Reduce Pediatric Prophylactic Antimicrobial Prescriptions Worldwide

Critical Need to Reduce Pediatric Prophylactic Antimicrobial Prescriptions Worldwide

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Cross-sectional survey represents the first assessment of antimicrobial prescription practices for prophylaxis in pediatric patients hospitalized worldwide.

Fluoroquinolone Use May Increase Risk for Aortic Aneurysm and Dissection

Fluoroquinolone Use May Increase Risk for Aortic Aneurysm and Dissection

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Additional studies are needed to investigate whether there are differences between individual fluoroquinolones with respect to the risk for aortic aneurysm.

It Costs $2.2 Billion a Year to Treat Antibiotic Resistance

It Costs $2.2 Billion a Year to Treat Antibiotic Resistance

The need for innovative new infection prevention programs, antibiotics, and vaccines to prevent and treat antibiotic-resistant infections is an international priority.

Novel Drug Combinations, Dosing Strategies Needed for <i>E faecalis</i> Bloodstream Infections

Novel Drug Combinations, Dosing Strategies Needed for E faecalis Bloodstream Infections

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Review highlights available treatment options and their limitations and provides direction for investigation of future novel combination therapies to further aid in the treatment of Enterococcus faecalis infective endocarditis.

CDC: Aggressive Action Needed to Contain Antibiotic Resistance

CDC: Aggressive Action Needed to Contain Antibiotic Resistance

Early aggressive action should be taken to prevent the spread of bacteria harboring unusual resistance genes.

Antibiotics, Acid-Suppressive Medications Tied to Allergic Disease

Antibiotics, Acid-Suppressive Medications Tied to Allergic Disease

The use of acid-suppressive medications and antibiotics during the first 6 months of infancy is tied to subsequent development of allergic disease.

2013 to 2016 Saw No Change in Antibiotic Prescribing Practices

2013 to 2016 Saw No Change in Antibiotic Prescribing Practices

Results suggest that inappropriate prescribing of antibiotics remains widespread, despite the concurrent release of several guideline-based best practices intended to reduce inappropriate antibiotic consumption.

Role of Vaccines in the Fight Against Antimicrobial Resistance

Role of Vaccines in the Fight Against Antimicrobial Resistance

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The potential role of vaccinations in combatting antimicrobial resistance (AMR) is currently undervalued. The distribution and development of new vaccines should be priorities in efforts to address the AMR crisis.

Firvanq Availability Replaces Need for Compounded Oral Vancomycin Solution

Firvanq Availability Replaces Need for Compounded Oral Vancomycin Solution

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FIRVANQ is commercially available in 25 and 50 mg/mL strengths in convenient 150 mL and 300 mL sizes.

<i>H pylori</i> Treatment Tied to Lower Metachronous Gastric Cancer Risk

H pylori Treatment Tied to Lower Metachronous Gastric Cancer Risk

Helicobacter pylori treatment is associated with a reduced rate of metachronous gastric cancer.

Brucellosis Treatment: Rifampicin vs Streptomycin

Brucellosis Treatment: Rifampicin vs Streptomycin

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The findings of this study indicated that rifampicin therapy significantly increased the risk of overall failure and relapse compared with streptomycin.

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