antiretrovirals

Point-of-Care Testing of HIV-Exposed Infants Improves Linkage to Care

Point-of-Care Testing of HIV-Exposed Infants Improves Linkage to Care

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Point-of-care testing of HIV-exposed infants at birth yielded results comparable to the standard of care laboratory-based testing and reduced time to result and time to antiretroviral therapy initiation.

Amphotericin and Flucytosine Safe, Effective for HIV-Associated Cryptococcal Meningitis

Amphotericin and Flucytosine Safe, Effective for HIV-Associated Cryptococcal Meningitis

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One-week amphotericin plus flucytosine was found to have comparable efficacy and safety profiles as the standard of care, 2-weeks amphotericin-based therapy, for treatment of HIV-associated cryptococcal meningitis in African patients.

Child Maintains HIV Remission Without ART Since 2008

Child Maintains HIV Remission Without ART Since 2008

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A child who was diagnosed with HIV at 1 month and received early treatment has suppressed the virus without anti-HIV therapy for 8.5 years.

New WHO Guidelines for Managing Pretreatment HIV Drug Resistance

New WHO Guidelines for Managing Pretreatment HIV Drug Resistance

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New WHO guidelines address the issue of how to manage pretreatment human immunodeficiency virus drug resistance (HIVDR) in countries where the prevalence of HIVDR is 10% or higher.

Long-Acting Injectable Antiretrovirals for HIV Effective and Safe

Long-Acting Injectable Antiretrovirals for HIV Effective and Safe

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The combination of long-acting intramuscular cabotegravir plus rilpivirine was demonstrated to be as effective as 3-drug daily oral ART for maintaining viral suppression of HIV-1 for up to 96 weeks in the LATTE-2 phase 2b study.

ART and PrEP: How Technological Advances Can Improve Adherence

ART and PrEP: How Technological Advances Can Improve Adherence

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Several technological advances have been developed to improve adherence to antiretroviral and preexposure prophylaxis therapy.

 Non-Protease Inhibitor Regimen Recommended in HIV Kidney Transplants

Non-Protease Inhibitor Regimen Recommended in HIV Kidney Transplants

Outcomes for HIV-positive patients are worse if they're on a PI-based vs non-PI-based ART regimen.

Early ART Initiation May Increase Bone Loss in Patients With HIV

Early ART Initiation May Increase Bone Loss in Patients With HIV

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Early antiretroviral therapy initiation may increase the rate of bone loss in HIV patients.

 Does ART Increase Risk of Diabetes in HIV-infected Patients?

Does ART Increase Risk of Diabetes in HIV-infected Patients?

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Antiretroviral therapy may be the most consistent determinant of diabetes in patients with HIV.

Advanced HIV Trends at ART Initiation in 10-High-Burden Countries

Advanced HIV Trends at ART Initiation in 10-High-Burden Countries

Decreases were found in the prevalence of advanced disease at initiation of antiretroviral therapy (ART) in 10 high-burden countries.

Adherence to Antiretroviral Therapy Increased From 2001 to 2010

Adherence to Antiretroviral Therapy Increased From 2001 to 2010

More Americans with HIV are adhering to antiretroviral therapy regimens.

HIV RNA Replication in Semen Occurs During Antiretroviral Therapy

HIV RNA Replication in Semen Occurs During Antiretroviral Therapy

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Study looks at the decay of HIV viral load in the genital tract by comparing the effect of different drug families on treatment-naive HIV-infected patients.

Life Expectancy for People With HIV Has Improved With ART

Life Expectancy for People With HIV Has Improved With ART

Young adult patients with HIV who are on treatment are living longer in North America and Europe.

HIV Transmission Through Breastfeeding: New Review and Expert Interview

HIV Transmission Through Breastfeeding: New Review and Expert Interview

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Mother-to-child HIV transmission rates are low in the presence of antiretroviral therapy but increase once ART stops at 6 months postpartum.

Can Bone Ultrasonography Accurately Detect HIV-induced Osteoporosis?

Can Bone Ultrasonography Accurately Detect HIV-induced Osteoporosis?

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Researchers assessed whether bone ultrasonography parameters were altered with a tenofovir treatment regimen compared to other antiretroviral drugs.

Impact of HIV Infection and ART on Evolving Risks of Heart Failure

Impact of HIV Infection and ART on Evolving Risks of Heart Failure

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HIV poses higher risks of heart failure even at younger ages of infection, and 25% of all new cases in the United States occur in people between age 13 and 24.

Drug-Resistant HIV in MSM: Do Sexual Networks Play a Role?

Drug-Resistant HIV in MSM: Do Sexual Networks Play a Role?

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Different HIV transmission dynamics are emerging, and the role of race/ethnicity and partnering patterns in the epidemic is becoming more apparent.

No Difference in Warfarin Dosing in HIV Patients With Venous Thrombosis

No Difference in Warfarin Dosing in HIV Patients With Venous Thrombosis

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No difference in warfarin requirements seen in HIV-infected and HIV-uninfected patients with venous thrombosis.

HIV-Positive Women With Obesity Benefit From Weight Loss

HIV-Positive Women With Obesity Benefit From Weight Loss

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Moderate diet-induced weight loss has important therapeutic cardiometabolic effects in HIV-positive women with obesity.

Mother-to-Child HIV Transmission: Cases of Missed Opportunities

Mother-to-Child HIV Transmission: Cases of Missed Opportunities

A small portion of HIV-infected women transmit the virus to their neonates despite high-quality care.

Rates of Perinatal HIV Decreased From 2002 to 2013 in US

Rates of Perinatal HIV Decreased From 2002 to 2013 in US

The estimated annual number of perinatally HIV-infected infants born from 2002 to 2013 has decreased from 216 to 69.

Atazanavir/Ritonavir Plus Lamivudine is as Safe, Effective as Triple Therapy

Atazanavir/Ritonavir Plus Lamivudine is as Safe, Effective as Triple Therapy

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Dual combination ART with atazanavir/ritonavir plus lamivudine demonstrated similar efficacy and safety as atazanavir/ritonavir plus 2 NRTIs at 48 weeks in the ATLAS-M trial.

Latent HIV May Exist in Both Resting and Non-Resting CD4 T cells

Latent HIV May Exist in Both Resting and Non-Resting CD4 T cells

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Researchers quantify inducible virus in long-term suppressed patients that was missed by the gold standard assay that measures the latent reservoir.

Early ART Reduces Bacterial Infection Risk in HIV With High CD4 Counts

Early ART Reduces Bacterial Infection Risk in HIV With High CD4 Counts

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Immediate antiretroviral therapy lowers the risk for severe bacterial infections in patients with HIV and high CD4. This effect may be mediated by increases in CD4 count, but not by increases in neutrophil count.

Achieving Optimal Neurodevelopmental Outcomes in HIV-Infected Infants

Achieving Optimal Neurodevelopmental Outcomes in HIV-Infected Infants

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HIV-infected infants who have a good response to ART are likely to recapture missed developmental milestones compared with uninfected infants but are unlikely to achieve full recovery.

Pretreatment HIV Drug Resistance Rises in Sub-Saharan Children

Pretreatment HIV Drug Resistance Rises in Sub-Saharan Children

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In sub-Saharan Africa, a 4-fold increase has been seen in pretreatment HIV drug resistance in children with prenatal exposure to ART.

HIV Research in Women: Expert Q&A

HIV Research in Women: Expert Q&A

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Drs Gianella and Karris discuss the many factors that play a role in the underrepresentation of women in HIV research.

ART Improves Liver Fibrosis in Majority of Patients With HIV

ART Improves Liver Fibrosis in Majority of Patients With HIV

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Combination antiretroviral therapy is associated with an overall reduction in liver fibrosis in HIV-infected patients with and without hepatitis co-infections.

Counseling HIV-Serodiscordant Couples: Key ART and PrEP Messages

Counseling HIV-Serodiscordant Couples: Key ART and PrEP Messages

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Standardized counseling messages accompanying ART and PrEP help maximize HIV prevention in HIV-serodiscordant couples.

Stribild HIV Post-Exposure Prophylaxis Brings Higher Completion Rate

Stribild HIV Post-Exposure Prophylaxis Brings Higher Completion Rate

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HIV PEP preferred regimen Stribild seems to be a good option for immunocompetent people without HIV infection due to the ease of use and tolerable adverse effect profile.

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