H. pylori Eradication Treatment Regimens

Share this content:
H. PYLORI ERADICATION TREATMENT REGIMENS
Acid Suppressant Dose Antibiotics Dose Treatment Duration
PROTON PUMP INHIBITOR (PPI) BASED REGIMENS
Aciphex (rabeprazole) 20mg twice daily amoxicillin 1000mg and clarithromycin 500mg; both twice daily 7 days with AM and PM meals
Nexium (esomeprazole) 40mg once daily 10 days
Prevacid (lansoprazole) 30mg twice daily 10 or 14 days
Prilosec (omeprazole) 20mg twice daily 10 days. If ulcer present at start, may continue omeprazole 20mg once daily in AM on Days 11−28
Prevacid (lansoprazole) 30mg three times daily amoxicillin 1000mg three times daily 14 days
Prilosec (omeprazole) 40mg once daily in AM clarithromycin 500mg three times daily 14 days. If ulcer present at start, may continue omeprazole 20mg once daily on Days 15−28.
One of the PPIs mentioned above* metronidazole 500mg and clarithromycin 500mg; both twice daily 10−14 days
One of the PPIs mentioned above* bismuth 525mg, metronidazole 250mg and tetracycline 500mg; all four times daily 10−14 days
H2 RECEPTOR ANTAGONIST BASED REGIMENS*
nizatidine 300mg daily at bedtime bismuth 525mg, metronidazole 250mg and tetracycline 500mg; all four times daily Take with 2 antibiotics for 2wks; may take H2 receptor antagonist for total of 4−8wks.
Pepcid (famotidine) 40mg daily at bedtime
Tagamet (cimetidine) 800mg daily at bedtime
Zantac (ranitidine) 300mg daily at bedtime
COMBINATION PRODUCTS
Omeclamox-Pak (omeprazole 20mg [2 caps], amoxicillin 500mg [4 caps], and clarithromycin 500mg [2 tabs] per pack). Take omeprazole 20mg, amoxicillin 1000mg, and clarithromycin 500mg twice daily. 10 days
Prevpac (lansoprazole 30mg [2 caps], amoxicillin 500mg [4 caps], and clarithromycin 500mg [2 tabs] per pack). Take lansoprazole 30mg, amoxicillin 1000mg, and clarithromycin 500mg twice daily. 10 or 14 days
Prilosec (omeprazole) 20mg twice daily Pylera (bismuth subcitrate 140mg, metronidazole 125mg, and tetracycline 125mg in 1 cap). Take 3 caps 4 times daily. Omeprazole sold separately. Take with full glass of water after meals for 10 days.
NOTES

*Not FDA-approved treatment regimens; regimens and doses are not necessarily those recommended in product labeling. Please refer to the H. Pylori treatment guidelines.

For all other FDA-approved regimens, see drug monographs at www.eMPR.com or contact company for full drug labeling.

REFERENCES

Chey WD, Wong BCY, et al. Management of Helicobacter pylori infection. Am J Gastroenterol 2007;102:1808−1825

Ables AZ, Simon I, Melton ER. Update on Helicobacter Pylori Treatment. Am Fam Physician 2007;72:351−8.

(Revised 11/2015)

You must be a registered member of Infectious Disease Advisor to post a comment.

Sign Up for Free e-newsletters