Irritable Bowel Syndrome Evaluation

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IRRITABLE BOWEL SYNDROME EVALUATION

Symptom-based criteria such as the Manning Criteria or Rome III Diagnostic Criteria for irritable bowel syndrome (IBS) have been used to enhance the precision of evaluating and diagnosing IBS.

THE MANNING CRITERIA FOR IBS¹

Chronic or recurrent abdominal pain for at least 6 months and two or more of the following:
   • Abdominal pain relieved with defecation
   • Abdominal pain associated with more frequent stools
   • Abdominal pain associated with looser stools
   • Abdominal distention
   • Feeling of incomplete evacuation after defecation
   • Mucus in stools

ROME III DIAGNOSTIC CRITERIA FOR IBS²

Diagnostic criterion*
Recurrent abdominal pain or discomfort† at least 3 days/month in the last 3 months associated with two or more of the following:
   • Improvement with defecation
   • Onset associated with a change in frequency of stool
   • Onset associated with a change in form (appearance) of stool
In pathophysiology research and clinical trials, a pain/discomfort frequency of least 2 days a week during screening evaluation is recommended for subject at eligibility.

NOTES

*Criterion fulfilled for the last 3 months with symptom onset at least 6 months prior to diagnosis

†“Discomfort“ means an uncomfortable sensation not described as pain.

REFERENCES

¹Adapted from Drossman D.A. An integrated approach to the irritable bowel syndrome. Ailment Pharmacol Ther 1999; 13 (suppl. 2):3–14. Review.

²Adapted from Drossman D.A., Corazziari E., Delvaux M., Spiller R.C., Talley N.J., Thompson W.G. & Whitehead W.E. (Eds.). (2006). Rome III: The functional gastrointestinal disorders (pp. 889, 907) (3rd ed.). McLean, VA: Degnon Associates, Inc. Used with permission of the Rome Foundation.

(Rev. 6/2015)

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