Clostridium Difficile

Feature Article

The Role of Dietary Trehalose in the Clostridium difficile Epidemic

The Role of Dietary Trehalose in the Clostridium difficile Epidemic

There remains a need for novel therapeutic strategies, such as a low-trehalose diet, for CDI treatment and prevention, and this is a potential area of future clinical investigation. The clinical benefit of such strategies should be proven before wide-scale changes to trehalose use in food manufacturing are undertaken.

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Fidaxomicin Effective for Long-Term Cure of Clostridium difficile

Fidaxomicin Effective for Long-Term Cure of Clostridium difficile

Fidaxomicin demonstrated the strongest evidence for being the most effective treatment in providing a long-term cure for C difficile infection.

C difficile Risk Higher With Stoma Reversal vs Colectomy

C difficile Risk Higher With Stoma Reversal vs Colectomy

Given the impact of postoperative Clostridium difficile infection, a heightened sense of suspicion should be given to symptomatic patients after stoma reversal.

Bezlotoxumab May Reduce Recurrent C difficile Infections in High-Risk Groups

Bezlotoxumab May Reduce Recurrent C difficile Infections in High-Risk Groups

Subgroup analyses of 2 MODIFY trial data confirmed prior C difficile infection (CDI), age ≥65 years, infection with 027/078/244 strain, compromised immunity, and severe CDI are risk factors for recurrent CDI.

Firvanq Availability Replaces Need for Compounded Oral Vancomycin Solution

Firvanq Availability Replaces Need for Compounded Oral Vancomycin Solution

FIRVANQ is commercially available in 25 and 50 mg/mL strengths in convenient 150 mL and 300 mL sizes.

Substantial Economic Burden Attributed to Recurrent Clostridium difficile

Substantial Economic Burden Attributed to Recurrent Clostridium difficile

Healthcare resource utilization and costs attributable to primary Clostridium difficile infection and recurrent C difficile infection are substantial.

C difficile Hospitalizations With Acute Kidney Injury Rising

C difficile Hospitalizations With Acute Kidney Injury Rising

Hospital admissions of patients with Clostridium difficile infection and accompanying acute kidney injury are increasing.

Extended-Pulsed Fidaxomicin Superior to Vancomycin for Sustained CDI Cure in Elderly

Extended-Pulsed Fidaxomicin Superior to Vancomycin for Sustained CDI Cure in Elderly

The EXTEND study addresses sustained cure as a primary measure of treatment success in a high-risk patient population, with recurrence monitored up to day 90.

Food Additive Linked to Growing Incidence of Clostridium difficile

Food Additive Linked to Growing Incidence of Clostridium difficile

Trehalose has been linked to the growing incidence and severity of healthcare-associated outbreaks caused by Clostridium difficile.

Probiotics Effective for Preventing C difficile-Associated Diarrhea

Probiotics Effective for Preventing C difficile-Associated Diarrhea

Short-term use of probiotics appears to be safe and effective when used along with antibiotics in patients who are not immunocompromised or severely debilitated.

Fecal Microbial Transplantation by Oral Capsule Not Inferior to Colonoscopy Delivery

Fecal Microbial Transplantation by Oral Capsule Not Inferior to Colonoscopy Delivery

A study investigated whether fecal microbiota transplantation delivered via oral capsules was as effective as microbiota delivered via colonoscopy for treating recurrent Clostridium difficile infection.

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