Diagnostics

MicroRNAs in Infectious Disease: Emerging Clinical Applications

MicroRNAs in Infectious Disease: Emerging Clinical Applications

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MicroRNAs are currently under investigation for various clinical applications in infectious disease because of their role in host response to infection and effects on innate and adaptive immune pathways.

Rapid, Point-of-Care Tool for Identifying Onchocerciasis in <i>L loa</i>-Endemic Areas

Rapid, Point-of-Care Tool for Identifying Onchocerciasis in L loa-Endemic Areas

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A test-and-not-treat strategy may help areas in which loiasis is endemic and onchocerciasis is hypoendemic so that individuals who are not at risk for serious adverse events are safely given ivermectin treatment.

HPV and Cytology Co-Testing Lowers Risk of Cervical Cancer

HPV and Cytology Co-Testing Lowers Risk of Cervical Cancer

Successive negative HPV and cytology co-testing is linked decrease risks of cervical cancer.

Update on Latent Tuberculosis Testing and Treatment

Update on Latent Tuberculosis Testing and Treatment

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A representative from the California Department of Public Health discusses latent TB infection testing and treatment recommendations and reasons why US physicians have been slow to test for and treat for the condition.

Zika Virus Persists in Tears of Convalescent Patients

Zika Virus Persists in Tears of Convalescent Patients

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Although detection of Zika virus from conjunctiva has been previously reported, presence of Zika virus RNA in conjunctiva at the late convalescent phase of the disease was not known.

Patients With Septic Thrombophlebitis Benefit From Follow-Up Blood Cultures

Patients With Septic Thrombophlebitis Benefit From Follow-Up Blood Cultures

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In critical care setting, thrombophlebitis can develop as a consequence of invasive procedures and, in case of bacteremia, it might represent a suitable medium that sustains bacterial growth and subsequent persistent endovascular infection.

Multibiomarker-Based Sepsis Score Predicts 30-Day Mortality

Multibiomarker-Based Sepsis Score Predicts 30-Day Mortality

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Results from this study are novel with respect to the combined use of leukocyte count, procalcitonin, interleukin-6, and paraoxonase-1 activity for mortality prediction.

When and How to Test for Lyme Disease, a Growing Threat

When and How to Test for Lyme Disease, a Growing Threat

Diagnosing Lyme disease can be difficult because symptoms vary from one person to another and can resemble symptoms of other infectious diseases spread by ticks.

Automated Molecular Assay Detects Drug-Resistant Tuberculosis

Automated Molecular Assay Detects Drug-Resistant Tuberculosis

An automated molecular assay can detect Mycobacterium tuberculosis with resistance to drugs directly from sputum specimens.

Increasing HCV Screening Using Electronic Health Record Prompts

Increasing HCV Screening Using Electronic Health Record Prompts

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The rates of anti-HCV orders and tests were collected from 4 medical specialties within a 30 mile radius of University of Michigan, Ann Arbor campus.

Challenges in Diagnosing Tuberculous Meningitis

Challenges in Diagnosing Tuberculous Meningitis

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Diagnosis of tuberculous meningitis is challenging, although new, next-generation rapid POC testing holds promise for greatly improved sensitivity. Shorter and more effective treatments are needed.

New Tool Guides Echocardiography Decision-Making in Bacteremia

New Tool Guides Echocardiography Decision-Making in Bacteremia

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Echocardiography is used to diagnose infective endocarditis, but it is not known which patients with non-beta-hemolytic streptococci bacteremia should undergo echocardiography.

Rapid Antigen Test Differentiates Zika and Dengue Cases

Rapid Antigen Test Differentiates Zika and Dengue Cases

A rapid immunochromatography approach can differentiate dengue and Zika virus cases

The T2Candida Panel Has Decreased Time to Therapy Initiation for Candidemia

The T2Candida Panel Has Decreased Time to Therapy Initiation for Candidemia

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Antimicrobial stewardship traditionally focuses on optimal use of antibacterial agents, not antifungal therapy.

Tuberculosis Diagnosis: Improved Blood Test by Qiagen to Hit Shelves

Tuberculosis Diagnosis: Improved Blood Test by Qiagen to Hit Shelves

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Qiagen announced on October 5, 2017, the marketing of an improved blood test for tuberculosis infection.

Accuracy of Negative Tuberculin Skin Test in Predicting In-Hospital Tuberculosis  Mortality

Accuracy of Negative Tuberculin Skin Test in Predicting In-Hospital Tuberculosis Mortality

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The relationship between negative tuberculin skin test and in-hospital mortality has not been previously studied.

T2 Candida Panel is Superior to Blood Cultures for Identifying Candidemia

T2 Candida Panel is Superior to Blood Cultures for Identifying Candidemia

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Compared to blood cultures, T2 Candida Panel is faster and more sensitive in detecting Candidemia.

Antibiotics Not Recommended in Pediatrics With Negative Rapid Strep Test Results

Antibiotics Not Recommended in Pediatrics With Negative Rapid Strep Test Results

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Pediatric patients with group A streptococcal pharyngitis should not be treated with antibiotics if results of an RADT are negative.

Risk Stratification in Febrile Infants Using Complete Blood Cell Counts

Risk Stratification in Febrile Infants Using Complete Blood Cell Counts

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The parameters of the complete blood cell count, WBC, ANC and platelet count were used to test accuracy in identifying infants with invasive bacterial infections.

Risk for TB Infection Predicted by New Scoring System

Risk for TB Infection Predicted by New Scoring System

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This new risk score may guide the identification of high-risk people who would benefit from preventative measures.

Time to Blood Culture Positivity Predicts Pneumonia Severity and Outcome

Time to Blood Culture Positivity Predicts Pneumonia Severity and Outcome

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Time to blood culture positivity was directly associated with disease severity and outcomes in bacteremic pneumococcal pneumonia.

Update on Pediatric HCV: Screening, Treatment, and Other Considerations

Update on Pediatric HCV: Screening, Treatment, and Other Considerations

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Experts discuss screening, treatment, and other considerations in pediatric HCV.

Clinical Update: Community-Acquired Pneumonia Following Sepsis

Clinical Update: Community-Acquired Pneumonia Following Sepsis

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The quick Sepsis-Related Organ Failure Assessment (qSOFA) clinical tool was superior to SIRS criteria for the evaluation of in-hospital mortality.

Point-of-Care Tests for HIV and T pallidum Infections: Utility of Smartphone-Based Electronic Reader

Point-of-Care Tests for HIV and T pallidum Infections: Utility of Smartphone-Based Electronic Reader

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A smartphone-based electronic reader with dual point of care tests were evaluated in the detection of antibodies to T pallidum and HIV.

Offering Rapid HIV Testing in EDs Increase Testing Rates

Offering Rapid HIV Testing in EDs Increase Testing Rates

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Rapid HIV testing offered to patients in addition to a clinician consultation increases the testing rate in the emergency department.

New Scoring System Predicts In-Hospital Mortality in Critically Ill Children With Sepsis

New Scoring System Predicts In-Hospital Mortality in Critically Ill Children With Sepsis

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A new organ dysfunction scoring system that predicts in-hospital mortality was validated in critically ill children admitted to the pediatric intensive care unit.

Tuberculosis Detection Could Improve With Conversion Value Change

Tuberculosis Detection Could Improve With Conversion Value Change

A change of QuantiFERON-TB interferon (IFN)γ values could improve tuberculosis detection.

CDC: No Evidence to Encourage More Frequent HIV Screening in MSM

CDC: No Evidence to Encourage More Frequent HIV Screening in MSM

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The CDC systematic review follows a trend of clinicians offering more frequent HIV screening to gay, bisexual, and other men who have sex with men, but the evidence is insufficient to warrant a change to the current recommendations.

FDA Issues Emergency Use Authorization for Multiplex Zika Virus Test

FDA Issues Emergency Use Authorization for Multiplex Zika Virus Test

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The FDA issued an Emergency Use Authorization for the Center for Infection and Immunity-ArboViroPlex rRT-PCR Test for Zika virus detection.

Point-of-Care Testing of HIV-Exposed Infants Improves Linkage to Care

Point-of-Care Testing of HIV-Exposed Infants Improves Linkage to Care

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Point-of-care testing of HIV-exposed infants at birth yielded results comparable to the standard of care laboratory-based testing and reduced time to result and time to antiretroviral therapy initiation.

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