Diagnostics

Viral Suppression in Children on ART Identified Via Quantitative HIV Antibody Levels

Viral Suppression in Children on ART Identified Via Quantitative HIV Antibody Levels

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For children receiving , HIV-1-specific antibody levels can be useful markers for measuring viral suppression or for low residual cell-associated HIV-1 DNA levels.

Evidence of Zika Congenital Syndrome in Pre-Term Newborn

Evidence of Zika Congenital Syndrome in Pre-Term Newborn

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Case-study demonstrates that epithelial cells are susceptible to congenitally acquired Zika virus.

New Assay Efficacious for Diagnosing Extrapulmonary Tuberculosis and Rifampin Resistance

New Assay Efficacious for Diagnosing Extrapulmonary Tuberculosis and Rifampin Resistance

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Xpert MTB/RIF may be helpful for confirming a diagnosis of extrapulmonary tuberculosis and can accurately detect resistance to rifampicin.

 ALT-70 Model Provides Accurate Diagnosis of Lower Extremity Cellulitis

ALT-70 Model Provides Accurate Diagnosis of Lower Extremity Cellulitis

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The widespread implementation of ALT-70 into clinical practice may help decrease misdiagnosis rates of lower-extremity cellulitis.

Tuberculosis Assessment More Efficient With Sputum Molecular Testing

Tuberculosis Assessment More Efficient With Sputum Molecular Testing

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In patients with possible tuberculosis, sputum molecular testing may facilitate a more accurate and efficient assessment of disease.

Review of Diagnostic Tools for Necrotizing Soft Tissue Infections

Review of Diagnostic Tools for Necrotizing Soft Tissue Infections

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The journal Annals of Emergency Medicine recently published an article reviewing the tools used to diagnose necrotizing soft tissue infection.

Aptima and RealTime Assay Have High Concordance in Monitoring HIV Viral Load

Aptima and RealTime Assay Have High Concordance in Monitoring HIV Viral Load

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The Aptima assay has 6-sigma performance, high concordance with the RealTime reference assay, and is user friendly and efficient, making it a good choice for laboratories that perform routine monitoring of HIV-1 viral loads.

Suboptimal Diagnostics Affect Management of Tickborne Diseases

Suboptimal Diagnostics Affect Management of Tickborne Diseases

Diagnostic and surveillance limitations and lack of treatment options, vaccines hamper efforts.

Point-of-Care Anti-Toxoplasma Antibody Test Can Reduce Costs and Morbidity

Point-of-Care Anti-Toxoplasma Antibody Test Can Reduce Costs and Morbidity

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The adoption of a point-of-care test to detect Toxoplasma gondii infection would substantially reduce costs and require significantly less infrastructure than conventional testing.

USPSTF Reaffirms Screening Recommendations for Syphilis in Pregnancy

USPSTF Reaffirms Screening Recommendations for Syphilis in Pregnancy

The USPSTF recommends screening all pregnant women for syphilis infection.

Zika Virus and Dengue Fever May Be Distinguished by Select Clinical Indicators

Zika Virus and Dengue Fever May Be Distinguished by Select Clinical Indicators

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Diagnostic indicators including conjunctivitis, platelet count, and monocyte count can be used to reliably distinguish between Zika virus and dengue fever.

Regular Feedback May Optimize Blood Culture Sample Volumes in the PICU

Regular Feedback May Optimize Blood Culture Sample Volumes in the PICU

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Interventions that included the distribution of simple weight-stratified guidelines for recommended blood volume and feedback to physicians were effective in optimizing blood volume culture in a PICU.

Prognostic Biomarkers to Guide Antibiotic Therapy in Critically Ill Patients

Prognostic Biomarkers to Guide Antibiotic Therapy in Critically Ill Patients

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Proadrenomedullin and procalcitonin have demonstrated superiority to C-reactive protein for predicting mortality and guiding antimicrobial therapy in critically ill patients with fever.

Delays in Lactate Testing Associated With Delayed Antibiotics, Increased Mortality in Sepsis

Delays in Lactate Testing Associated With Delayed Antibiotics, Increased Mortality in Sepsis

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Delayed lactate measurement is associated with delayed antibiotic administration and increased mortality in patients with increased lactate levels.

Rapid Diagnostics Reduce Time to Optimal Antimicrobial Therapy in Children

Rapid Diagnostics Reduce Time to Optimal Antimicrobial Therapy in Children

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Time to optimal antimicrobial therapy for positive blood cultures was assessed in a pediatric population.

Platform Manufacturing May Speed Pandemic Vaccine Development

Platform Manufacturing May Speed Pandemic Vaccine Development

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With the advent of platform manufacturing technology, vaccines can be developed quickly to stop the spread of outbreaks.

Procalcitonin Is Effective Biomarker for Guiding Antibiotic Treatment in Sepsis

Procalcitonin Is Effective Biomarker for Guiding Antibiotic Treatment in Sepsis

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Researchers conducted a literature review to assess the effectiveness and safety of procalcitonin to guide treatment in patients with known or suspected sepsis.

Predictors of Post-Chikungunya Chronic Polyarthralgia

Predictors of Post-Chikungunya Chronic Polyarthralgia

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Researchers reported on the first outbreak of an Asian lineage of chikungunya virus in Aruba.

Early Flow Cytometry Predictive of Clinical Deterioration in Sepsis

Early Flow Cytometry Predictive of Clinical Deterioration in Sepsis

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Increased circulating immature granulocytes at the acute phase of sepsis are linked to clinical worsening, especially when associated with T-cell lymphopenia.

Simple Blood-Based PCR Test Can Predict Progression to Tuberculosis

Simple Blood-Based PCR Test Can Predict Progression to Tuberculosis

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Study identifies and validates a simple PCR-based test from accessible blood samples that predicts TB in heterogeneous African populations with intermediate to high TB burdens.

Pediatric Pneumonia: Sensitivity of Lung Ultrasound vs Chest Radiography

Pediatric Pneumonia: Sensitivity of Lung Ultrasound vs Chest Radiography

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Lung ultrasound was more effective in diagnosing pediatric community-acquired pneumonia than chest radiography.

Molecular Laboratory Test Can Discriminate Sepsis From Noninfectious SIRS

Molecular Laboratory Test Can Discriminate Sepsis From Noninfectious SIRS

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The SeptiCyteTM LAB may be an effective complementary diagnostic tool to clinical assessment of critically ill adult patients in discriminating between sepsis and noninfectious systemic inflammation syndrome.

New Rabies Test Could Radically Change Testing and Treatment

New Rabies Test Could Radically Change Testing and Treatment

A new rapid rabies test for animals could revolutionize screening and spare humans unnecessary painful treatment.

Screening Blood Donations for Zika Virus Is Costly With Low Yield

Screening Blood Donations for Zika Virus Is Costly With Low Yield

Screening blood donations for Zika virus in the United States is costly with low yield.

Best Diagnosis for Sepsis May Be a 2-Step Approach With qSOFA and SIRS

Best Diagnosis for Sepsis May Be a 2-Step Approach With qSOFA and SIRS

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The association of both criteria (qSOFA and SIRS) could provide a better model to initiate or escalate therapy in patients with sepsis.

Low-Dose CT May Modify Pneumonia Diagnosis in Elderly Patients

Low-Dose CT May Modify Pneumonia Diagnosis in Elderly Patients

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Low-dose computed tomography may assist clinicians in modifying diagnosis of elderly patients who are admitted with suspected pneumonia.

UTICalc: A New Calculator for Estimating the Probability of UTI in Children

UTICalc: A New Calculator for Estimating the Probability of UTI in Children

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The UTICalc calculator can be used to guide testing and treatment in children with suspected urinary tract infection.

Wide Range of Clinical Manifestations Identified in Chronic Recurrent Multifocal Osteomyelitis

Wide Range of Clinical Manifestations Identified in Chronic Recurrent Multifocal Osteomyelitis

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A series of reported cases shows that the range of associated clinical manifestations is heterogeneous in chronic nonbacterial osteomyelitis or chronic recurrent multifocal osteomyelitis.

Curbing Overuse of Blood Cultures in the Emergency Department

Curbing Overuse of Blood Cultures in the Emergency Department

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Training on adherence to guidelines, the development of guidelines specific to the pediatric population, and the employment of tools and techniques to decrease contamination of blood cultures could decrease the overuse of blood cultures.

CDC: Declining Incidence of TB in the United States Remains Inadequate for Elimination

CDC: Declining Incidence of TB in the United States Remains Inadequate for Elimination

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Control of active tuberculosis (TB) and a major effort to decrease latent TB infection are both necessary to reduce morbidity and achieve TB elimination in the United States.

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