The risk for infection and malignancy associated with biologic use complicates the management of patients with a deficient immune system. Equip yourself with the information needed to effectively manage these complex patients.
Rapid treatment of sepsis using mandated care bundles improves outcomes.
Binding pocket and peripheral structural modifications of vancomycin improve its antimicrobial activity and durability.
An expert interview on recent developments in molecular point-of-care and near-patient testing for infectious diseases.
Gilead submitted their single-tablet regimen containing bictegravir, emtricitabine, and tenofovir alafenamide for HIV-1 treatment to the FDA.
In an effort to combat extensive drug-resistance in gonorrhea, a new assay identifies patients who may still have a response to an older, less reliable therapy.
An imbalance in gut microbiota may be associated with the progression of Parkinson's disease.
Dr Sara Gianella Weibel talks with Anthony B, a patient with HIV and end-stage amyotrophic lateral sclerosis and the first participant enrolled in the "Last Gift" end-of-life study, about his experience as part of this new end-of-life model to study HIV persistence.
Dr Sara Gianella Weibel talks with Jeff Taylor, community activist and long-term HIV survivor, about a new end-of-life model to study HIV persistence.
Dr Sara Gianella Weibel talks with Dr Davey Smith, head of the Division of Infectious Disease at the University of California, San Diego, about a proposed new model to study HIV persistence, called the Last Gift study.
The FDA has approved delafloxacin (Baxdela™, Melinta Therapeutics), a new antibacterial drug to treat acute bacterial skin and skin structure infections.
Placental malaria during pregnancy may raise the risk of malaria infection in childhood by promoting maternal microchimerism, in which the fetus acquires noninherited maternal cells during pregnancy. Maternal microchimerism may be the mechanism by which the fetus develops tolerance to malaria antigens, leading to an impaired malaria-specific immune response.
Experts review novel antibiotic therapies that may limit the impact on the gut microbiome, as well as passive immunization products that may bolster the immune response to C difficile toxins and possibly reduce the frequency of toxigenic strains.
Health care workers who had multiple annual vaccinations for influenza demonstrated lower serologic responses to the most current vaccination compared with those who had less than 2 previous vaccinations.
Hepatitis C virus infection may increase the risk for type 2 diabetes, but whether a causal relationship exists is unclear. Screening for type 2 diabetes in this population may have important public health implications.
Medical liability remains a troubling issue today, placing a burden on patients and a financial burden of medical practitioners and insurance providers.
Study finds that over one-fifth of those prescribed an antibiotic for community-acquired pneumonia experience treatment failure.
Dr Sara Gianella talks with Brooke Sullivan, a transgender woman and HIV activist, about ways to improve transgender individuals' involvement in HIV research.
Dr Sara Gianella talks with Dr Sheldon Morris, from the University of California San Diego AntiViral Research Center about an upcoming PrEP study in transgender people, including understanding HIV prevention in this population, uptake of PrEP, and adherence to treatment.
Report provides new recommendations and guidance for vaccination providers and travelers about the use of lyophilized CVD 103-HgR (Vaxchora, PaxVax, Redwood City, California).
Passage of the 2017 budget, along with congressional approval of the AHCA, leaves large holes in the funding of the proposed national approach to infectious disease control.
Bi-directional mechanisms linking periodontal disease to the development of rheumatoid arthritis may offer biomarkers for the development of RA and treatment objectives that influence the courses of both inflammatory conditions.
Mother-to-child HIV transmission rates are low in the presence of antiretroviral therapy but increase once ART stops at 6 months postpartum.
Elisabeth Aron, MD, MPH, takes a look at the legal risks of providing medical curbside consultations.
Theravance Biopharma announced positive results from 3 studies on Vibativ (telavancin), a lipoglycopeptide antibiotic.
Patients with end-stage renal disease on dialysis are at higher risk for infective endocarditis than the general population and are also likely to have poorer outcomes, such as stroke and death.
A booster dose of pertussis vaccine is safe and immunogenic for pediatric patients with inflammatory bowel disease.
The CDC has issued an alert regarding new recommendations for the treatment of Shigella infection.
Maternal Tdap vaccination was found to be highly protective against pertussis in newborns.
WHO, NIH, and FDA call for the negative or inconclusive results of clinical studies to be published or made publicly available.
Despite the increase in coverage under the ACA, data suggest Medicaid patients often had increased wait times for appointments to see healthcare providers.
Phase 1b trial finds tetravalent E coli bioconjugate vaccine candidate in women with recurrent UTI safe and immunogenic.
The development of new device technologies points to the need for new strategies to monitor their continuing safety and efficacy.
Drs Kociolek and Shulman, from the division of infectious diseases at the Ann & Robert H. Lurie Children's Hospital of Chicago in Illinois, review all the current vaccine candidates in development for Clostridium difficile infection.
Persons living with HIV infection have a higher risk for cardiovascular disease; use of some antiretroviral agents can exacerbate this risk.
Recent research found that end-of-rotation transition in care was linked to significantly higher in-hospital mortality.
The AMA and ACP voice their opposition after House leadership proposes a new health care act in replacement of Obamacare.
The FDA has released draft guidance documents for appropriate marketing communication on medical products and devices.
An expert Q&A with Susannah L. Rose, PhD, on the prevalence of industry funding of advocacy groups and what clinicians should consider when interpreting research outcomes.
Symptoms of Seoul virus infection include fever, headache, and back pain.
Critics of the FDA's current restriction on blood donation from MSM argue that it is unnecessary and discriminatory, and propose a policy based on individual risk rather than sexual orientation.
Drs Gianella and Karris discuss the many factors that play a role in the underrepresentation of women in HIV research.
Medical students learn better when they are in a good state of mind, researchers found.
A virtual simulation allows clinicians to role play to improve clinician-patient communication.
A review of coronary heart disease in patients with HIV.
More than 100 clinicians and researchers identified the top 10 most anticipated medical innovations of 2017.
A new vaccine for Ebola showed high efficacy in preventing the development of Ebola in clusters of people exposed to the virus, and protection was also conferred to those who were not vaccinated.
Speculation surrounds the new administration's plan for the Affordable Care Act (ACA).
Researchers and physicians explore what's working and not working in medical education.
Although there are delays in implementation, artificial intelligence has many potential applications in medicine.
The increase in direct patient access to online health records confers multiple benefits, though disparities in access should be addressed.
While 86% of all persons living with HIV in the US know that they are HIV-infected, only an estimated 35% actually achieve viral suppression.
Hand washing compliance was less than 30% among caregivers working with children between infancy and 5-years-old.
The CDC's Advisory Committee on Immunization Practices voted unanimously to recommend Vaxchora for US travelers to areas of active cholera transmission.
Although certain behavioral interventions did not work, methods are needed to reduce antibiotic overuse.
Researchers found only 3 cases of follicular trachoma and one case of infection in 2 districts, well below the World Health Organization criteria.
The reimbursement gap between male and female doctors might be due to coding practices and accuracy.
Person-to-person or environmental transmission is low in mcr-1 gene antibiotic resistant bacteria.
Ramped up efforts to encourage more men who have sex with men to get tested for HIV have made an impact, but rates are still lower than needed.
Two reports call attention to importance of diagnosing, treating HBV.
Many providers still find EMRs vexing, even after all these years.
New treatment strategies are necessary as researchers work to prevent C difficile infection.
WHO releases new treatment guidelines for chlamydia, gonorrhea, and syphilis
The researchers noted that earlier studies had shown that statins have proven anti-inflammatory effects, and older adults who usually take these medications are also more at risk for complications from influenza.
Sustained control efforts are necessary, 'as the effects of the flood on malaria transmission may continue for up to one year after the initial event.'
The guidelines note that TB treatment should begin as soon as the patient is suspected of having active TB disease, even before test results confirm the diagnosis.
S aureus colonization was associated with particular SLE phenotypes.
Published in 2005, the previous guidelines recommended different lengths of treatment time for antibiotic therapy based on the bacterium causing the infection.
The updated guidelines note that coccidioidomycosis, originally nicknamed San Joaquin Valley fever, may be overlooked as a cause of illness, which may lead to unnecessary blood imaging tests and antibiotic use.
The update also offers guidance regarding the prudent use of HCV resistance testing, a source of considerable confusion for practitioners.
Signs of emerging resistance to azithromycin suggests that this drug will be next in the long line of antibiotics to which gonorrhea bacteria have become resistant - a list that includes penicillin, tetracycline, and fluoroquinolones.
CDC activated its Emergency Operations Center (EOC) for the Ebola response on July 9, 2014.
The study revealed that polyphenols such as baicalein, luteolin, and rosmarinic acid, fatty acids namely monolaurin and 10-HAD, and micronutrients like iodine and vitamins D3 and C were particularly effective.
One important issue derived from the study is that it sets a target that may be useful for the norms evaluating hand hygiene products, and also for future studies comparing different hand hygiene products.
Importance of C difficile transmission routes varies by setting.
Failure to change or remove contaminated gloves carries a high-risk of healthcare-associated pathogens transmission.
Numerous studies have shown no benefit in continuing antibiotics after surgery.
Addressing Altered Vaccine Immunogenicity and Low Vaccination Rates in Those With Autoimmune Diseases
Despite decades of research on the disproportionate impact of infection on those with rheumatic disease, patients in this population are less likely than those without rheumatic disease to undergo routine vaccination.
Of the 1,103 patients tested, 40% were treated with antibiotics for gonorrhea and/or chlamydia; of those treated, 76.6% ultimately tested negative for having the STD.
About 22% of 6232 patients did not complete latent tuberculosis (LTBI) treatment.
Problems identified in these building-associated outbreaks included inadequate disinfectant levels, human error, and equipment breakdowns
Following the year-long study period, the intervention group had a testing rate of 63.7% and the comparison group had 42%.
Evidence may suggest that universal test of cure may not be necessary for all patients.
Researchers found the multidrug resistant bacteria in a woman who sought treatment for UTI.
While Chlamydia trachomatis is the most reported genitourinary pathogen causing ReA, other bacteria including E. coli and Enterococcus faecalis have been implicated in the pathogenesis of ReA.
Thanks in large part to antiretroviral therapy, patients with HIV are living longer, but they and the physicians who treat them are facing unique challenges as they age.
Healthy and Safe Swimming Week begins on May 23, 2016.
Patients and providers have different perceptions, behaviors, and knowledge on antibiotic usage.
College-aged students may benefit from continued education regarding the spread of HPV, especially oral transmission.
Emory researchers have made new data analyses of where gay and bisexual men are most likely to be infected with HIV. The data will be used to direct vital HIV resources to areas of the most need.
A second CDC study, published online this month in Clinical Infectious Diseases, shows that annual hepatitis C-related mortality in 2013 surpassed the total combined number of deaths from 60 other infectious diseases reported to CDC.
Challenges of managing inflammatory arthritis in patients infected with HIV include difficulties in assessing disease activity and limited safety information for the use of immunosuppresive drugs in this patient population.
Patients depend on their medical team to help them get well, and the first step is making sure healthcare professionals aren't exposing them to new infections.
Foodnet officials attribute the increases to the wider use of culture-independent diagnostic tests (CIDTs).
WHO issued its first-ever recommendations on the treatment of hepatitis C virus (HCV) two years ago, but since then, several new medicines, specifically direct-acting antivirals (DAAs), have been approved.
The six-step technique was determined to be microbiologically more effective for reducing the median bacterial count (3.28 to 2.58) compared to the three-step method.
Cancer prevention efforts for patients with HIV should focus on smoking cessation and appropriate screening based on recommendations for the general population.
Guidelines for patients with coinfection sorely needed.
The date indicated nucleic amplification tests were sensitive and specific for CDI when cultures were used as the reference standard.
Nevirapine-based ART did not have a negative impact on levonorgestrel exposure or efficacy.
Sign Up for Free e-newsletters
Infectious Disease Advisor Articles
- Antibiotic-Resistant Bacteria Have Long Resided on Ready-to-Eat Foods
- Infections Complicate Biologic Use in Autoimmune Inflammatory Disorders
- Tuberculosis Vaccine May Reverse Type 1 Diabetes
- No Benefits Seen for Adjunctive Clindamycin in Cellulitis
- Telbivudine During Early Pregnancy Prevents HBV Transmission
- Maternal Antibodies Hinder Antigenic Responses to Vaccines in Infants
- Sepsis-Related Mortality Decreased With Rapid Implementation of Protocol
- New Assay Targets Susceptibility to Ciprofloxacin in Gonorrhea
- Gut Microbiota Associated With Parkinson's Disease Progression
- Decrease Rate of S aureus Resistance Seen With Certain Antibiotics