Diagnosis of tuberculous meningitis is challenging, although new, next-generation rapid POC testing holds promise for greatly improved sensitivity. Shorter and more effective treatments are needed.
The high cost of DAA-based regimens remains an ethical issue and an obstacle to treatment accessibility. Shorter treatment regimens may offer substantial cost savings, improved treatment adherence, and a reduced rate of side effects.
Data have shown patients with genotype 3 HCV have faster progression of fibrosis and higher rates of cirrhosis, severe steatosis, and hepatocellular carcinoma.
Investigators review results from the first study to assess the efficacy of a Vi-conjugate vaccine using a controlled human infection model of typhoid fever.
In recent years, a link between childhood Helicobacter pylori and gastric cancer in adulthood has elevated the need to detect and treat H pylori in asymptomatic children.
Vaginal microbiota dominated by L iners has been shown to exhibit rapid change in composition in and out of community states similar to bacterial vaginosis.
Optimizing outcomes with an antibiotic stewardship programs requires a team approach that involves point-of-care providers.
Physicians can help avoid contributing to antibiotic resistance by recognizing and using appropriate alternative treatments, and having a strategy so that patients are not on antibiotics for a long period of time.
The incidence of neurocognitive impairment is high in HIV-infected population, despite the introduction of combination antiretroviral therapy (CART).
Pregnant women who received vaccines containing the pH1N1 antigen for 2 consecutive influenza seasons may have increased risk for spontaneous abortion 28 days postvaccination.
Despite continual efforts aimed at finding new treatment options, HCC still has a very low 5-year survival rate, less than 20%, as many patients are diagnosed at an advanced stage of the disease.
Incidence of adverse events with delafloxacin (Baxdela™, Melinta Therapeutics) was comparable to the combination regimen of vancomycin plus aztreonam across 2 phase 3 registrational ABSSSI studies.
An international panel of experts applied the GRADE system and choose 7 PICO questions to generate recommendations for HAP/VAP.
Learn more about when stopping antiretroviral therapy (ART) may be necessary, why patients discontinue ART, predicting viral suppression, and predicting and encouraging adherence.
Researchers believe implementation of treatment guidelines for children with sickle cell disease with acute chest syndrome may decrease hospital readmission rates.
New data confirms delafloxacin shows high response rates against MRSA.
In addition to prevention measures, switching off the ARTs associated with bone loss and administering intravenous bisphosphonate, a bone resorption inhibitor, can be an effective strategy for preventing bone loss seen in HIV-infected individuals.
How can hospitals protect themselves against recent ransomware attacks?
One of the main challenges in managing and controlling hepatitis B infection today is identifying people who are infected and ensuring that they have access to suitable treatment.
An analysis on the cost saving success of accountable care organizations.
Mycobacterium tuberculosis engages the host immune response to drive immunopathology and tissue destruction by disrupting negative regulatory pathways in human macrophages.
Follow-up blood cultures may have little utility in the management of Gram-negative bacilli bacteremia, according to data from a recent study.
The CDC Health Alert Network has issued an advisory regarding an increase in cases of the intestinal illness cyclosporiasis.
While Mycoplasma genitalium is emerging as one of the most common causes of sexually transmitted infections, and is often underrecognized and treated with ineffective antibiotics.
A tetravalent dengue vaccine candidate (TDV) was found to be safe and immunogenic in an ongoing phase 2 trial. A second TDV dose induced enhanced immunogenicity against DENV-3 and DENV-4 in children who were seronegative before vaccination, supporting the initiation of phase 3 trial to evaluate the efficacy and safety of TDV given in a 2-dose schedule 3 months apart.
Experts review biotherapeutics for the prevention of C difficile infection, including probiotics, fecal microbiota transplantation, and nontoxigenic C difficile.
Epidemiological data demonstrate a link between HCV infection and cardiovascular disease, whereas treatment studies suggest viral eradication may lower the risk for cardiovascular morbidity and mortality.
Diagnosis is one of the primary difficulties in managing hospital acquired pneumonia.
One-week amphotericin plus flucytosine was found to have comparable efficacy and safety profiles as the standard of care, 2-weeks amphotericin-based therapy, for treatment of HIV-associated cryptococcal meningitis in African patients.
Patients with HCV are at risk for several extrahepatic sequelae. Find out what they are and the new treatment options for managing HCV in patients with rheumatic symptoms.
Cytomeglovirus infection is associated with a range of diagnostic and treatment challenges and a relatively high transmission rate from the mother to the fetus.
Several technological advances have been developed to improve adherence to antiretroviral and preexposure prophylaxis therapy.
An Ebola virus vaccine, rVSVΔG-ZEBOV-GP, provided 100% protection against Ebola in a prior phase 3 trial. A new study reports long-term safety data and shows that the vaccine induces an antibody response for at least 1 year.
The risk for infection and malignancy associated with biologic use complicates the management of patients with a deficient immune system. Equip yourself with the information needed to effectively manage these complex patients.
Rapid treatment of sepsis using mandated care bundles improves outcomes.
An expert interview on recent developments in molecular point-of-care and near-patient testing for infectious diseases.
In an effort to combat extensive drug-resistance in gonorrhea, a new assay identifies patients who may still have a response to an older, less reliable therapy.
An imbalance in gut microbiota may be associated with the progression of Parkinson's disease.
Dr Sara Gianella Weibel talks with Anthony B, a patient with HIV and end-stage amyotrophic lateral sclerosis and the first participant enrolled in the "Last Gift" end-of-life study, about his experience as part of this new end-of-life model to study HIV persistence.
Dr Sara Gianella Weibel talks with Jeff Taylor, community activist and long-term HIV survivor, about a new end-of-life model to study HIV persistence.
Dr Sara Gianella Weibel talks with Dr Davey Smith, head of the Division of Infectious Disease at the University of California, San Diego, about a proposed new model to study HIV persistence, called the Last Gift study.
Experts review novel antibiotic therapies that may limit the impact on the gut microbiome, as well as passive immunization products that may bolster the immune response to C difficile toxins and possibly reduce the frequency of toxigenic strains.
Hepatitis C virus infection may increase the risk for type 2 diabetes, but whether a causal relationship exists is unclear. Screening for type 2 diabetes in this population may have important public health implications.
Medical liability remains a troubling issue today, placing a burden on patients and a financial burden of medical practitioners and insurance providers.
Study finds that over one-fifth of those prescribed an antibiotic for community-acquired pneumonia experience treatment failure.
Dr Sara Gianella talks with Brooke Sullivan, a transgender woman and HIV activist, about ways to improve transgender individuals' involvement in HIV research.
Dr Sara Gianella talks with Dr Sheldon Morris, from the University of California San Diego AntiViral Research Center about an upcoming PrEP study in transgender people, including understanding HIV prevention in this population, uptake of PrEP, and adherence to treatment.
Passage of the 2017 budget, along with congressional approval of the AHCA, leaves large holes in the funding of the proposed national approach to infectious disease control.
Bi-directional mechanisms linking periodontal disease to the development of rheumatoid arthritis may offer biomarkers for the development of RA and treatment objectives that influence the courses of both inflammatory conditions.
Mother-to-child HIV transmission rates are low in the presence of antiretroviral therapy but increase once ART stops at 6 months postpartum.
Elisabeth Aron, MD, MPH, takes a look at the legal risks of providing medical curbside consultations.
Theravance Biopharma announced positive results from 3 studies on Vibativ (telavancin), a lipoglycopeptide antibiotic.
A booster dose of pertussis vaccine is safe and immunogenic for pediatric patients with inflammatory bowel disease.
WHO, NIH, and FDA call for the negative or inconclusive results of clinical studies to be published or made publicly available.
Despite the increase in coverage under the ACA, data suggest Medicaid patients often had increased wait times for appointments to see healthcare providers.
Phase 1b trial finds tetravalent E coli bioconjugate vaccine candidate in women with recurrent UTI safe and immunogenic.
The development of new device technologies points to the need for new strategies to monitor their continuing safety and efficacy.
Drs Kociolek and Shulman, from the division of infectious diseases at the Ann & Robert H. Lurie Children's Hospital of Chicago in Illinois, review all the current vaccine candidates in development for Clostridium difficile infection.
Persons living with HIV infection have a higher risk for cardiovascular disease; use of some antiretroviral agents can exacerbate this risk.
Recent research found that end-of-rotation transition in care was linked to significantly higher in-hospital mortality.
The AMA and ACP voice their opposition after House leadership proposes a new health care act in replacement of Obamacare.
The FDA has released draft guidance documents for appropriate marketing communication on medical products and devices.
An expert Q&A with Susannah L. Rose, PhD, on the prevalence of industry funding of advocacy groups and what clinicians should consider when interpreting research outcomes.
Critics of the FDA's current restriction on blood donation from MSM argue that it is unnecessary and discriminatory, and propose a policy based on individual risk rather than sexual orientation.
Drs Gianella and Karris discuss the many factors that play a role in the underrepresentation of women in HIV research.
Medical students learn better when they are in a good state of mind, researchers found.
A virtual simulation allows clinicians to role play to improve clinician-patient communication.
A review of coronary heart disease in patients with HIV.
More than 100 clinicians and researchers identified the top 10 most anticipated medical innovations of 2017.
Speculation surrounds the new administration's plan for the Affordable Care Act (ACA).
Researchers and physicians explore what's working and not working in medical education.
Although there are delays in implementation, artificial intelligence has many potential applications in medicine.
The increase in direct patient access to online health records confers multiple benefits, though disparities in access should be addressed.
While 86% of all persons living with HIV in the US know that they are HIV-infected, only an estimated 35% actually achieve viral suppression.
Hand washing compliance was less than 30% among caregivers working with children between infancy and 5-years-old.
The CDC's Advisory Committee on Immunization Practices voted unanimously to recommend Vaxchora for US travelers to areas of active cholera transmission.
Although certain behavioral interventions did not work, methods are needed to reduce antibiotic overuse.
The reimbursement gap between male and female doctors might be due to coding practices and accuracy.
Person-to-person or environmental transmission is low in mcr-1 gene antibiotic resistant bacteria.
Ramped up efforts to encourage more men who have sex with men to get tested for HIV have made an impact, but rates are still lower than needed.
Two reports call attention to importance of diagnosing, treating HBV.
Many providers still find EMRs vexing, even after all these years.
New treatment strategies are necessary as researchers work to prevent C difficile infection.
WHO releases new treatment guidelines for chlamydia, gonorrhea, and syphilis
The researchers noted that earlier studies had shown that statins have proven anti-inflammatory effects, and older adults who usually take these medications are also more at risk for complications from influenza.
Sustained control efforts are necessary, 'as the effects of the flood on malaria transmission may continue for up to one year after the initial event.'
The guidelines note that TB treatment should begin as soon as the patient is suspected of having active TB disease, even before test results confirm the diagnosis.
S aureus colonization was associated with particular SLE phenotypes.
Published in 2005, the previous guidelines recommended different lengths of treatment time for antibiotic therapy based on the bacterium causing the infection.
The updated guidelines note that coccidioidomycosis, originally nicknamed San Joaquin Valley fever, may be overlooked as a cause of illness, which may lead to unnecessary blood imaging tests and antibiotic use.
The update also offers guidance regarding the prudent use of HCV resistance testing, a source of considerable confusion for practitioners.
Signs of emerging resistance to azithromycin suggests that this drug will be next in the long line of antibiotics to which gonorrhea bacteria have become resistant - a list that includes penicillin, tetracycline, and fluoroquinolones.
CDC activated its Emergency Operations Center (EOC) for the Ebola response on July 9, 2014.
The study revealed that polyphenols such as baicalein, luteolin, and rosmarinic acid, fatty acids namely monolaurin and 10-HAD, and micronutrients like iodine and vitamins D3 and C were particularly effective.
One important issue derived from the study is that it sets a target that may be useful for the norms evaluating hand hygiene products, and also for future studies comparing different hand hygiene products.
Importance of C difficile transmission routes varies by setting.
Failure to change or remove contaminated gloves carries a high-risk of healthcare-associated pathogens transmission.
Numerous studies have shown no benefit in continuing antibiotics after surgery.
Addressing Altered Vaccine Immunogenicity and Low Vaccination Rates in Those With Autoimmune Diseases
Despite decades of research on the disproportionate impact of infection on those with rheumatic disease, patients in this population are less likely than those without rheumatic disease to undergo routine vaccination.
Of the 1,103 patients tested, 40% were treated with antibiotics for gonorrhea and/or chlamydia; of those treated, 76.6% ultimately tested negative for having the STD.
Sign Up for Free e-newsletters
Infectious Disease Advisor Articles
- Are Antibiotic Stewardship Programs the Antidote to Antibiotic Overuse?
- Better Detection and Treatment Needed for H pylori Infections in Children
- FDA Approves New Hepatitis B Vaccine for Adults
- Strategies for Preventing Antibiotic Resistance in Acne
- Oral HPV Prevalence Higher in Men With Concurrent Genital HPV
- Study Finds Burnout Occurs in Over Half of US Surgeons
- HPV Vaccine Linked to Lower Respiratory Papillomatosis Rates
- Novel Antifungal Agent for Treatment of Aspergillus flavus Infections
- Inappropriate Antibiotic Use for Acute Bronchitis Highest in Younger Adults
- ACP, CDC Provides Best Practice Advice on Hepatitis B Management