A study showed that telbivudine administered during early and middle pregnancy prevented transmission of hepatitis B virus infection from mother to infants in all participants receiving antiviral treatment.
Direct-acting antiviral treatment of hepatitis C virus improved glycemic control for patients with type 2 diabetes.
Hepatocellular carcinoma decreases beyond year 5 of entecavir/tenofovir therapy in Caucasian patients with chronic hepatitis B virus.
Point-of-care test was found to have high sensitivity and specificity for detecting HCV RNA in both capillary whole-blood samples collected by finger stick and in plasma samples collected by venipuncture.
Expert insight from Leslie B. Lilly, MD, FRCPC, medical director of GI Transplantation from the Toronto General Hospital in Canada, about direct-acting antivirals in the management of hepatitis C virus in the liver transplantation setting.
The European Association for the Study of the Liver raises concerns over Cochrane Review of direct acting antivirals for hepatitis C virus.
For patients with HCV and HIV coinfection, treatment is effective with standardized nurse/pharmacist support at urban clinics.
The Turkish Society of Rheumatology proposed a guideline of hepatitis screening in patients with rheumatoid arthritis.
Liver cancer has become the fastest growing cause of cancer deaths in the Unites States.
Universal vaccination against hepatitis B virus infection prevented non-Hodgkin lymphoma in adolescents in Taiwan, an endemic area for hepatitis B virus infection.
Most opioid-dependent pregnant patients understand that intravenous drug use is a major transmission modality of hepatitis C virus.
A combination pill of sofosbuvir, velpatasvir, and voxilaprevir is nearly 100% effective in curing hepatitis C in patients whose disease returned after treatment with direct-acting antiviral agents.
The FDA and CDC are warning consumers of a hepatitis A virus risk in contaminated frozen tuna.
Hepatitis C virus infection may increase the risk for type 2 diabetes, but whether a causal relationship exists is unclear. Screening for type 2 diabetes in this population may have important public health implications.
Dobutamine stress perfusion echocardiography can detect microvascular perfusion abnormalities that predict cardiovascular outcomes in candidates for liver transplantation.
Hepatitis B virus reactivation has become a safety concern in patients with HBV and HCV coinfection receiving direct-acting antiviral agents.
Researchers evaluated the safety and efficacy of transplantation of kidneys from HCV genotype 1-viremic donors into HCV-negative patients, followed by elbasvir-grazoprevir (Zepatier) treatment.
Women with a high hepatitis B viral load who receive tenofovir during pregnancy have a significantly reduced risk for passing on the virus to their child, without an increase in the risk of adverse events.
Hepatitis C virus infections among pregnant women have nearly doubled between 2009 and 2014 in the United States according to the CDC.
Researchers found that there was a doubling in the number of reproductive-aged women with acute and past or present HCV infection in the National Notifiable Disease Surveillance System.
The CDC reports that new hepatitis C virus infections in the US have nearly tripled over 5 years.
An investigational direct-acting antiviral treatment combination improves patient-reported outcomes in addition to sustained virologic response in patients with HCV, especially patients with cirrhosis.
Findings from the EXPEDITION-1 study, a phase 3 trial, evaluated the efficacy and safety of glecaprevir/pibrentasvir for the treatment of chronic HCV infection in patients with genotype 1, 2, 4, 5, or 6 and compensated cirrhosis.
Investigational dosage of once-daily ledipasvir/sofosbuvir was safe and highly efficacious in children age 6 to 11 with chronic HCV infection.
The new European Association for the Study of the Liver (EASL) clinical practice guidelines for hepatitis B virus infection identifies new management strategies for an incurable disease.
Patients with chronic HCV infection who have achieved a sustained virologic response with treatment are considered cured, but they may still be at risk for complications such as hepatocellular carcinoma. The American Gastroenterological Association Institute addresses these issues in its clinical practice update on managing patients cured of HCV infection.
Statin use decreased rates of decompensation in patients with liver cirrhosis due to HBV and HCV infections and, to a lesser extent, in patients with alcohol-induced cirrhosis. Mortality rates were also reduced in statin users with HBV-related cirrhosis.
While prior studies have found an association between hepatitis C and the risk for Parkinson disease, the association between hepatitis B and Parkinson disease is new and needs further confirmation.
Clinical pharmacists can encourage preventive measures on reducing HCV transmission, increase education adherence, assist in initiating HCV treatment, assist in monitoring clinical and adverse effects, and facilitate medication acquisition.
Despite being the seventh leading cause of death in the world, viral hepatitis accounts for less than 1% of the National Institutes of Health research budget.
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Infectious Disease Advisor Articles
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