Research is needed to understand how to prioritize supplementation and reach new testers, to educate men about the limitations of the current self-test, and to invest in the development and evaluation of self-tests able to detect early infection.
While immunocompromised patients are the most susceptible to CNS fungal infections, they can also occur in immunocompetent patients undergoing invasive procedures such as neurosurgery and in patients exposed to contaminated devices or drugs.
Standard-dose efavirenz-based short cycle therapy is a viable option for virologically suppressed HIV-1-infected young people receiving first-line antiretroviral therapy with 3-monthly viral load monitoring.
Steady increases in the syphilis incidence rate occurred through 2015, particularly among people with HIV who are younger, non-Hispanic/Latino, and are men who have sex with men.
The FDA has received reports of serious neural tube birth defects in babies born to women who received dolutegravir for HIV.
The use of Truvada for PrEP in the adolescent population was based on a single-arm, open-label clinical study (ATN113) among 67 HIV-1 negative young men (aged 15 to 17 years) who have sex with men (YMSM).
Important strategies to consider for people involved in the criminal justice systems include linkage to antiretroviral therapy for those who are HIV positive and linkage to PrEP postrelease and/or beginning PrEP before people are released so they build up adherence.
The approval of Retacrit was based on a review of evidence that included human pharmacokinetic/pharmacodynamic data and clinical immunogenicity data which demonstrated a high degree of similarity between Retacrit and its reference product.
Nivolumab and pembrolizumab can be safe and effective for patients with NSCLC and HIV.
Jaimie P. Meyer, MD, from the Yale School of Medicine, discusses her work on identifying opportunities to reduce risk for HIV transmission, particularly in women involved in the criminal justice system.
The cancer burden among persons living with HIV is projected to shift by 2030.
The number of adverse birth outcomes was not higher with tenofovir, emtricitabine, and ritonavir-boosted lopinavir than with zidovudine, lamivudine, and ritonavir-boosted lopinavir or tenofovir, emtricitabine, and ritonavir-boosted atazanavir in HIV-infected women and their infants in the United States.
Researchers investigated effects of eplerenone on insulin sensitivity, inflammatory indices, and other metabolic parameters in HIV.
The risk for skin cancer was examined in patients with HIV infection.
Clinical presentation and outcomes in HIV-infected patients with Legionella pneumonia did not differ from patients without HIV infection.
Mental health problems are 1 of the most important reasons for failing to engage in long-term control of HIV.
In-utero exposure to tenofovir-emtricitabine not associated with higher risk of adverse birth outcomesMay 01, 2018
Pairwise comparisons of tenofovir-emtricitabine and ritonavir-boosted lopinavir (TDF-FTC-LPV/r), zidovudine-lamivudine and ritonavir-boosted lopinavir (ZDV-3TC-LPV/r), and tenofovir-emtricitabine and ritonavir-boosted atazanavir (TDF-FTC-ATV/r) HIV regimens among pregnant women with HIV showed all 3 regimens had comparable risks of preterm birth, low birth weight, and neonatal death.
The approval of Trogarzo was supported by a clinical trial (N=40) of heavily treatment-experienced adults with multidrug resistant HIV-1 infection who continued to have high levels of HIV RNA in their blood despite antiretroviral therapy.
Study showed very small changes in HIV viral load among patients who had gaps in primary care that exceeded 6 months but were less than 9 months in duration.
Findings highlight the clinical importance of enhanced treatment protocols designed to reduce the duration and frequency of depressive episodes in women living with HIV.
Less than half of women and a quarter of men with recent sexual activity receive sexual risk assessment.
Considering the resurgence of measles in Europe and the risk of severe complications associated with the infection, individuals with HIV born after 1970 or those who were vertically infected should be tested for measles-specific IgG, irrespective of ethnic background or migration status.
A non-targeted testing approached revealed a high HIV prevalence with a significant burden of undiagnosed HIV infection in the emergency department.
Study results support the indication of glecaprevir/pibrentasvir as the first 8-week pangenotypic treatment option for HCV/HIV-1 coinfected patients without cirrhosis.
Katie Burk, MPH, presented measures undertaken by the city of San Francisco to provide integrated responses to the concurrent HIV/HCV and opioid public health epidemics.
More comprehensive research will be needed to further investigate cerebrospinal fluid p24 by high-sensitivity assay as a marker for neurocognitive impairment during poorly controlled HIV and as a marker for HIV central nervous system reactivation during latency reversal therapy.
Generic antiretroviral agents have had a dramatic effect on outcomes in developing nations, and their availability in developed countries is rapidly expanding as more brand-name drugs are coming off patent. But unique challenges surrounding their use remain.
Interventions for diabetes prevention and management may be needed to reduce the risk for diabetes in patients with HIV.
About half of pregnant women with HIV infection underwent cesarean delivery between 1998 and 2013.
The absence of availability of amphotericin B or in conditions in which amphotericin B cannot be administered safely, the oral combination of fluconazole plus flucytosine provides an effective and sustainable alternative.
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Infectious Disease Advisor Articles
- Importance of PrEP for People Involved in Criminal Justice Systems
- Increasing Incidence of Syphilis in People With HIV
- FDA: Possible Risk of Neural Tube Birth Defects With Certain Antiretroviral Agents
- Fungal Infections of the CNS: Diagnostic and Treatment Approaches
- Study Supports Development of a Vaccine for Recurrent Vulvovaginal Candidiasis
- Early Flow Cytometry Predictive of Clinical Deterioration in Sepsis
- Could a New Universal Tuberculosis Regimen Help End the TB Pandemic?
- Hepatitis C Virus Infection Linked to Gut Dysbiosis
- Two Hepatitis C Virus Infection Treatments to Be Discontinued
- Antibiotic Use During Pregnancy May Increase Risk for Childhood Asthma