IDWeek 2017

Latent Tuberculosis May Benefit From 3-Month Rifapentine, Isoniazid Tx

Latent Tuberculosis May Benefit From 3-Month Rifapentine, Isoniazid Tx

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Three months of rifapentine + isoniazid using directly observed therapy resulted in a higher completion rate and no loss of follow-up for latent tuberculosis.

Challenges in Multidrug-Resistant HIV Management: Ibalizumab Safe, Effective

Challenges in Multidrug-Resistant HIV Management: Ibalizumab Safe, Effective

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Ibalizumab may be a valuable option in patients with multidrug-resistant HIV.

Examining Drug-Drug Interactions in Women With HIV: ART and Hormonal Contraception

Examining Drug-Drug Interactions in Women With HIV: ART and Hormonal Contraception

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Examining the barriers to co-use of hormonal contraceptives and antiretroviral therapy in women with HIV.

Abacavir ART Does Not Increase Risk for Myocardial Infarction or CVD

Abacavir ART Does Not Increase Risk for Myocardial Infarction or CVD

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Abacavir-containing antiretroviral therapy does not appear to confer an increased risk for myocardial infarction or coronary artery disease.

The T2Candida Panel Has Decreased Time to Therapy Initiation for Candidemia

The T2Candida Panel Has Decreased Time to Therapy Initiation for Candidemia

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Antimicrobial stewardship traditionally focuses on optimal use of antibacterial agents, not antifungal therapy.

Efficacy of Procalcitonin-Guided Antimicrobial Stewardship Initiative for Diagnosing Pneumonia

Efficacy of Procalcitonin-Guided Antimicrobial Stewardship Initiative for Diagnosing Pneumonia

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Implementation of a procalcitonin diagnostic algorithm improves diagnostic yield and reduces hospital length of stay in bacterial pneumonia.

Ribaxamase May Prevent Opportunistic Infections During IV β-lactam Treatment

Ribaxamase May Prevent Opportunistic Infections During IV β-lactam Treatment

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SYN-004, ribaxamase, is an oral B-lactamase medication to be combined with intravenous β-lactam antibiotics to prevent disruption of the gut microbiome.

Minorities With Low Income and Poor Education Receive Lower Uptake of PCV13

Minorities With Low Income and Poor Education Receive Lower Uptake of PCV13

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Multiple disparities exist in rates of adult vaccination for 13-valent pneumococcal conjugate vaccine.

Accuracy of Negative Tuberculin Skin Test in Predicting In-Hospital Tuberculosis  Mortality

Accuracy of Negative Tuberculin Skin Test in Predicting In-Hospital Tuberculosis Mortality

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The relationship between negative tuberculin skin test and in-hospital mortality has not been previously studied.

Stroke Outcomes Similar in People With, Without HIV

Stroke Outcomes Similar in People With, Without HIV

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Stroke outcomes between people with and without HIV were comparable.

Efficacy of Delafloxacin in Treating Community-Acquired Bacterial Pneumonia

Efficacy of Delafloxacin in Treating Community-Acquired Bacterial Pneumonia

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The efficacy of delafloxacin in treating Streptococcus pneumoniae, Haemophilius influenzae, and Moraxella catarrhalis isolates was examined.

Dyslipidemia in Children With HIV Started on Antiretroviral Therapy

Dyslipidemia in Children With HIV Started on Antiretroviral Therapy

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Researchers aim to identify changes in blood lipid profiles among children with HIV after 12 months of using antiretroviral therapy.

Recurrent Acute Uncomplicated Cystitis in Women: Examining the Efficacy of Preventive Hydration

Recurrent Acute Uncomplicated Cystitis in Women: Examining the Efficacy of Preventive Hydration

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Data to support hydration as a preventive measure for women with recurrent acute uncomplicated cystitis are sparse.

EMERALD Trial: Week 48 Results Demonstrate Efficacy in Single-Tablet HIV Therapy

EMERALD Trial: Week 48 Results Demonstrate Efficacy in Single-Tablet HIV Therapy

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Primary study end point was noninferiority of the single-tablet regimen vs control, related to virologic rebound, cumulative through week 48.

T2 Candida Panel is Superior to Blood Cultures for Identifying Candidemia

T2 Candida Panel is Superior to Blood Cultures for Identifying Candidemia

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Compared to blood cultures, T2 Candida Panel is faster and more sensitive in detecting Candidemia.

Macrolides Superior to Beta-Lactams in Pediatric Community-Acquired Pneumonia

Macrolides Superior to Beta-Lactams in Pediatric Community-Acquired Pneumonia

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Macrolides, despite inferior anti-pneumococcal activity, are the most commonly prescribed antibiotic class for CAP in Children.

Delafloxacin: Tolerable, Effective Against Gram-Negative Pathogens for ABSSSI

Delafloxacin: Tolerable, Effective Against Gram-Negative Pathogens for ABSSSI

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Delafloxacin is effective against gram-negative pathogens and has a similar tolerability profile to vancomycin/aztreonam when used in patients with an ASSSSI.

"Hard Stop" Alert May Reduce <i>C difficile</i> Orders for Laxative-Taking Patients

"Hard Stop" Alert May Reduce C difficile Orders for Laxative-Taking Patients

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A "hard stop" requiring providers to think critically about C difficile testing in the presence of laxative use or absence of documented diarrhea strengthened CDI testing stewardship.

Delafloxacin is Effective, Safe for MRSA Treatment in ABSSSI

Delafloxacin is Effective, Safe for MRSA Treatment in ABSSSI

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Fixed dose delafloxacin IV/oral monotherapy was comparable to vancomycin/aztreonam in patients with ABSSSI and gram-positive pathogens.

Do Traditional Risk Factors for CVD Play Larger Role in HIV-Positive Premenopausal Women?

Do Traditional Risk Factors for CVD Play Larger Role in HIV-Positive Premenopausal Women?

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Traditional risk factors may incur a higher risk for CVD in HIV-positive premenopausal women than HIV infection itself.

Safety, Immunogenicity of Investigational Zika Vaccine Examined

Safety, Immunogenicity of Investigational Zika Vaccine Examined

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Volunteer participants received either 1 mg or 2 mg doses of the GLS-5700 vaccine over 12 weeks.

Methicillin-Susceptible <i>Staphyloccocus aureus</i> Carriers Unlikely to Acquire MRSA

Methicillin-Susceptible Staphyloccocus aureus Carriers Unlikely to Acquire MRSA

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Study results can be used to support an antimicrobial stewardship policy discouraging empiric coverage for MRSA infections in a population of MSSA carriers.

Community-Acquired <i>Clostridium difficile</i> Risk Factors in Children

Community-Acquired Clostridium difficile Risk Factors in Children

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Outpatient antibiotic use may reduce community-acquired C diff infections in pediatric at-risk populations

Diagnostic Practices for Sepsis Identification in Febrile Infants

Diagnostic Practices for Sepsis Identification in Febrile Infants

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Infantile sepsis evaluations vary considerably and could benefit from the development of an updated, standardized guideline.

Ridinilazole Preserves Gut Microbiome Diversity in Treatment of <i>C difficile</i> Infection

Ridinilazole Preserves Gut Microbiome Diversity in Treatment of C difficile Infection

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Compared with fidaxomicin, ridinilazole preserved gut microbiome diversity to a greater extent in the treatment of Clostridium difficile infection.

Bictegravir Co-Formulation Maintained High Levels of Virologic Suppression in HIV

Bictegravir Co-Formulation Maintained High Levels of Virologic Suppression in HIV

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Phase 3 study assessed efficacy and safety of switching to bictegravir/emtricitabine/tenofovir alafenamide from a multi-tablet regimen containing a boosted protease inhibitor regimen in virologically suppressed patients with HIV.

Novel Injectable Antibiotic Fosfomycin Safe, Effective in Treating cUTI

Novel Injectable Antibiotic Fosfomycin Safe, Effective in Treating cUTI

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Researchers compared the safety and efficacy of fosfomycin with piperacillin/tazobactam in 465 hospitalized adults with complicated urinary tract infections or acute pyelonephritis in multicenter phase 2/3 study.

No Difference in Adverse Events Between Delafloxacin or Vancomycin/Aztreonam in ABSSSI

No Difference in Adverse Events Between Delafloxacin or Vancomycin/Aztreonam in ABSSSI

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Incidence of adverse events with delafloxacin (Baxdela™, Melinta Therapeutics) was comparable to the combination regimen of vancomycin plus aztreonam across 2 phase 3 registrational ABSSSI studies.

IDWeek 2017 Preview: Sessions You Should Not Miss

IDWeek 2017 Preview: Sessions You Should Not Miss

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IDWeek 2017 will include a session on the largest collection of new antibiotic phase 3 studies ever presented at a meeting.

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