Dr McKinnell provides a summary of drugs in development for infections caused by Gram-negative bacteria, including carbapenem-resistant Pseudomonas aeruginosa and carbapenem-resistant Enterobacteriaceae.
Clofazimine was safe and well-tolerated as part of a multidrug regimen for the treatment of children with Mycobacterium abscessus odontogenic infections.
Rajesh T. Gandhi, MD, discusses management of coinfections, including HPV and sexually transmitted infections, in people with HIV.
For uncomplicated Gram-negative bloodstream infections, oral beta-lactam therapy may be an appropriate stepdown option.
Inappropriate prescribing of outpatient antibiotics for the treatment of uncomplicated urinary tract infections are higher than previously estimated.
Isoniazid-rifapentine regimen sees high completion rates for latent tuberculosis infection.
Vancomycin administered via continuous infusion was found to achieve the recommended VAN trough of 15-20mg/L faster and with less risk of adverse events compared to administration via intermittent infusion.
The aim of this study was to identify and characterize PrEP patients who remain at high risk for HIV as demonstrated by STI diagnosis after starting PrEP.
Mothers' use of antibiotics affects infant gut composition up to a month later.
Among HIV-infected, virologically suppressed black adults, FTC/TAF showed improvements in renal and bone safety compared to FTC/TDF.
Only a small percentage of people with HIV/HCV coinfection receive treatment for hepatitis C.
In 2004, syphilis screening guidelines were changed to recommend rapid plasma regain testing every 3 to 6 months.
Three months of rifapentine + isoniazid using directly observed therapy resulted in a higher completion rate and no loss of follow-up for latent tuberculosis.
Ibalizumab may be a valuable option in patients with multidrug-resistant HIV.
Examining the barriers to co-use of hormonal contraceptives and antiretroviral therapy in women with HIV.
Abacavir-containing antiretroviral therapy does not appear to confer an increased risk for myocardial infarction or coronary artery disease.
Antimicrobial stewardship traditionally focuses on optimal use of antibacterial agents, not antifungal therapy.
Implementation of a procalcitonin diagnostic algorithm improves diagnostic yield and reduces hospital length of stay in bacterial pneumonia.
SYN-004, ribaxamase, is an oral B-lactamase medication to be combined with intravenous β-lactam antibiotics to prevent disruption of the gut microbiome.
Multiple disparities exist in rates of adult vaccination for 13-valent pneumococcal conjugate vaccine.
The relationship between negative tuberculin skin test and in-hospital mortality has not been previously studied.
Stroke outcomes between people with and without HIV were comparable.
The efficacy of delafloxacin in treating Streptococcus pneumoniae, Haemophilius influenzae, and Moraxella catarrhalis isolates was examined.
Researchers aim to identify changes in blood lipid profiles among children with HIV after 12 months of using antiretroviral therapy.
Data to support hydration as a preventive measure for women with recurrent acute uncomplicated cystitis are sparse.
Primary study end point was noninferiority of the single-tablet regimen vs control, related to virologic rebound, cumulative through week 48.
Compared to blood cultures, T2 Candida Panel is faster and more sensitive in detecting Candidemia.
Macrolides, despite inferior anti-pneumococcal activity, are the most commonly prescribed antibiotic class for CAP in Children.
Delafloxacin is effective against gram-negative pathogens and has a similar tolerability profile to vancomycin/aztreonam when used in patients with an ASSSSI.
A "hard stop" requiring providers to think critically about C difficile testing in the presence of laxative use or absence of documented diarrhea strengthened CDI testing stewardship.
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Infectious Disease Advisor Articles
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- Mosaic HIV-1 Vaccine Induces Responses in Humans and Monkeys
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- Harms Reporting Limited in Trials of Prebiotics, Probiotics, Synbiotics
- Trials Supporting FDA Approval of Breakthrough Drugs Examined
- Etravirine Indication Expanded to Include Younger HIV Patients