Ceftaroline Fosamil Associated With Shorter ABSSSI-Related Hospital Stay
The average infection-related length of stay in the entire cohort was 6 days. Photo Credit: ISM.
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Patients with acute bacterial skin and skin structure infection (ABSSSI) experience a shorter infection-related length of hospital stay when treated with ceftaroline fosamil (CPT) vs vancomycin (VAN), according to findings from a retrospective study presented at IDWeek 2017, held October 4-8 in San Diego, California.
“Hospital visits for ABSSSIs are rising,” noted the investigators, “[and] inadequate treatment results in longer stays and increased recurrences. CPT is approved for ABSSSI, [al]though real-world clinical comparative data are limited.”
Investigators performed a retrospective, propensity-matched cohort study of patients with ABSSSI (N=311) who were treated with either CPT (n=119) or VAN (n=192). The researchers aimed to evaluate and compare the infection-related length of stay in both groups. Patients were included if they had ≥3 clinical signs that required ≥72 hours VAN or CPT initiated ≤120 hours after the diagnosis of ABSSSI.
The average infection-related length of stay in the entire cohort was 6 days. Comorbidities of patients in each group included peripheral vascular disorders (24%), chronic pulmonary disease (26%), and diabetes (38%).
Cellulitis, lower extremity, and methicillin-resistant Staphylococcus aureus comprised all ABSSSIs in the study population (54%, 48%, and 21%, respectively). Approximately 64% of subjects with ABSSSI were not required to undergo surgical treatment, and 55% were eventually able to switch from intravenous (IV) antibiotics to their oral form.
Overall, the median infection-related length of stay for patients treated with CPT was significantly lower than patients receiving VAN (5 vs 7 days, respectively; (P =.007). Investigators found that CPT was also associated with shorter infection-related length of hospital stay even after adjusting for the type of ABSSSI, among other factors (P =.013).
“Early CPT use may be considered for patients who need IV antibiotics for ABSSSI treatment to facilitate early discharge,” concluded the investigators. Additional studies are needed to confirm these findings.
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Trinh TD, Zasowski EJ, Claeys K, et al. Ceftaroline fosamil (CPT) versus vancomycin (VAN) for acute bacterial skin and skin structure infections (ABSSSI). Presented at: IDWeek 2017; October 4-8, 2017; San Diego, California. Poster 1884.