Abnormal Platelet Aggregation Studies
Acquired causes of platelet dysfunction:
Ingestion of aspirin or aspirin-like compounds or NSAIDs
Impaired renal function
Exposure to cardiopulmonary bypass
Presence of a paraprotein
Congenital causes of platelet dysfunction:
Storage pool disease
Disorders of thromboxane production or action
Suggested Additional Lab Testing
Platelet aggregation studies with characteristic response patterns for the different agonists help identify Glanzmann thrombasthenia, Bernard-Soulier disease, aspirin ingestion, and defects in thromboxane production or action.
Plasma or serum BUN and creatinine and urinalysis to assess renal function should be ordered.
If aspirin ingestion is suspected but denied by patient, measurement of salicylates (metabolites of aspirin) may prove useful.
Bone marrow biopsy may be useful if myeloproliferative disease is suspected.
Serum protein electrophoresis can reveal a paraprotein. To identify platelet granule storage pool disease, assays for the granular contents of platelets can be performed, but these are complex, costly, and rarely performed.
Copyright © 2017, 2013 Decision Support in Medicine, LLC. All rights reserved.
No sponsor or advertiser has participated in, approved or paid for the content provided by Decision Support in Medicine LLC. The Licensed Content is the property of and copyrighted by DSM.
Sign Up for Free e-newsletters
Infectious Disease Advisor Articles
- Pediatric Outpatient Antimicrobial Stewardship: Minimizing Antibiotic Duration
- Better Detection and Treatment Needed for H pylori Infections in Children
- Are Antibiotic Stewardship Programs the Antidote to Antibiotic Overuse?
- FDA Approves New Hepatitis B Vaccine for Adults
- Strategies for Preventing Antibiotic Resistance in Acne
- Dual Regimen Provides Simple and Safe Salvage Therapy in HIV-1
- Effectiveness of Ledipasvir/Sofosbuvir for Acute HCV Infection in HIV
- Diclofenac Inferior to Norfloxacin for UTI Symptom Relief
- Legionella Linked to Most Drinking Water-Associated Outbreaks
- Preventing HCV Transmission: Utility of Needle/Syringe Programs