Pediatric illnesses

Gastric Acid Inhibitors May Increase Late-Onset Sepsis Risk in Preterm Infants

Gastric Acid Inhibitors May Increase Late-Onset Sepsis Risk in Preterm Infants

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Study showed that very low birth weight infants exposed to gastric acid inhibitors have significantly increased odds of developing infections, and that the risk increases with each day of exposure.

Safety of Clofazimine in Treating Children With <i>Mycobacterium abscessus</i> Infections

Safety of Clofazimine in Treating Children With Mycobacterium abscessus Infections

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Clofazimine was safe and well-tolerated as part of a multidrug regimen for the treatment of children with Mycobacterium abscessus odontogenic infections.

Strategies for Preventing Group B Streptococcus in Infants

Strategies for Preventing Group B Streptococcus in Infants

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Expert from the National Center for Immunization and Respiratory Diseases, a division of the CDC, discusses prevention strategies for group B streptococcus in infants, including the development of a maternal vaccine.

Meningococcal B Vaccine Elicits Bactericidal Responses Against Diverse Strains

Meningococcal B Vaccine Elicits Bactericidal Responses Against Diverse Strains

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MenB-FHbp was safe and immunogenic after dose 2 and dose 3 and was also associated with more injection-site reactions than hepatitis A virus vaccine and saline.

Neonatal Herpes Simplex Virus Uncommon After Meningitis Evaluation

Neonatal Herpes Simplex Virus Uncommon After Meningitis Evaluation

Young infants assessed for central nervous system infection rarely have herpes simplex virus.

Maternal Antibiotic Exposure Affects Infant Fecal Microbiota Following Vaginal Delivery

Maternal Antibiotic Exposure Affects Infant Fecal Microbiota Following Vaginal Delivery

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Infants born via vaginal delivery to mothers exposed to intrapartum antibiotic prophylaxis for group B Streptococcus demonstrated altered fecal microbiota immediately following birth.

Epidemiology of Pediatric Zika Virus Infection in the United States

Epidemiology of Pediatric Zika Virus Infection in the United States

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Majority of children presented with only 2 of 4 main symptoms (fever, maculopapular rash, conjunctivitis, and/or arthralgia).

Pediatric Urinary Tract Infection: Diagnostic and Treatment Challenges

Pediatric Urinary Tract Infection: Diagnostic and Treatment Challenges

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Experts discuss the various imaging modalities for children who require diagnostic workup beyond urine culture, as well as the consequences of overusing antibiotics and antibiotic route of administration.

Routine Chest Radiographs Not Recommended in Suspected Pediatric Pneumonia

Routine Chest Radiographs Not Recommended in Suspected Pediatric Pneumonia

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Chest X-rays do not differentiate between viral and bacterial pathogens, and they do not subsequently alter the course of treatment.

Can the Influenza Vaccine Prevent Acute Otitis Media?

Can the Influenza Vaccine Prevent Acute Otitis Media?

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Vaccination may confer modest reductions in acute otitis media (AOM) and AOM-targeted antibiotic use but use of influenza vaccine as a strategy to reduce AOM is likely unjustified.

Tools for Predicting Prolonged Hospitalization in Pediatric CAP

Tools for Predicting Prolonged Hospitalization in Pediatric CAP

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Pleural fluid lactic dehydrogenase and glucose are useful parameters in determining the severity of pediatric CAP.

Combination β-lactam, Macrolide Pneumonia Therapy in Children Not More Effective

Combination β-lactam, Macrolide Pneumonia Therapy in Children Not More Effective

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The results of this study question the routine empirical use of macrolide combination therapy in this population.

Urinary Tract Infections Common Cause of Late-Onset Sepsis in Neonates

Urinary Tract Infections Common Cause of Late-Onset Sepsis in Neonates

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Prospective studies are needed to determine the incidence of UTI in the NICU population without predisposing UTI factors when fluconazole prophylaxis is administered to examine whether routine urinalysis would still be justified.

UTI Rate Drops in Infants on Long IV Therapy Without Increase in Readmission

UTI Rate Drops in Infants on Long IV Therapy Without Increase in Readmission

Rate of infants with a UTI who received 4 or more days of intravenous antibiotics decreased from 2005 to 2015.

Intravenous Zanamivir Safe, Efficacious in Children With Influenza

Intravenous Zanamivir Safe, Efficacious in Children With Influenza

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Zanamivir is a neuraminidase inhibitor approved in the United States as an oral inhalation powder for acute, uncomplicated influenza in children ≥7 years of age and prophylaxis in children ≥5 years of age.

Factors Associated With Lower Risk for Early-Onset Sepsis in Premature Infants

Factors Associated With Lower Risk for Early-Onset Sepsis in Premature Infants

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Identification of premature infants at low risk of early onset sepsis may help guide decisions for initiating and/or discontinuing empirical antibiotic treatments in the first days of life.

Rates of Infection in Juvenile Idiopathic Arthritis Treated With Biologic Therapy

Rates of Infection in Juvenile Idiopathic Arthritis Treated With Biologic Therapy

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Researchers examine serious infection risk factors in patients with juvenile idiopathic arthritis receiving biologic therapy.

Osteomyelitis in Children More Common in the Summer, Spring

Osteomyelitis in Children More Common in the Summer, Spring

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Study assessed the effects of weather trends on the occurrence and severity of acute hematogenous osteomyelitis in affected children.

Preterm Infants at Higher Risk for RSV Hospitalization Following 2014 Guidance

Preterm Infants at Higher Risk for RSV Hospitalization Following 2014 Guidance

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New data shows a higher risk of respiratory syncytial virus hospitalization for preterm infants during the 2015-2016 season vs data from the previous season.

Better Detection and Treatment Needed for <i>H pylori</i> Infections in Children

Better Detection and Treatment Needed for H pylori Infections in Children

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In recent years, a link between childhood Helicobacter pylori and gastric cancer in adulthood has elevated the need to detect and treat H pylori in asymptomatic children.

Factors Associated With Thrombocytopenia in Neonatal Sepsis

Factors Associated With Thrombocytopenia in Neonatal Sepsis

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Maternal hypertension, intravascular thrombosis, and Gram-negative sepsis were independent risk factors for thrombocytopenia in multivariate analysis.

Using Protein and Biomarkers to Improve Risk Stratification in Sepsis

Using Protein and Biomarkers to Improve Risk Stratification in Sepsis

Addition of previously unconsidered genes from the PERSEVERE model can improve mortality risk stratification for children with septic shock.

Guidelines for Infection Prevention in Pediatric Ambulatory Settings Updated

Guidelines for Infection Prevention in Pediatric Ambulatory Settings Updated

Guidelines have been updated for infection prevention in pediatric ambulatory settings.

Efficacy of Continuous vs Intermittent Vancomycin for Pediatric MRSA Infections Evaluated

Efficacy of Continuous vs Intermittent Vancomycin for Pediatric MRSA Infections Evaluated

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Vancomycin administered via continuous infusion was found to achieve the recommended VAN trough of 15-20mg/L faster and with less risk of adverse events compared to administration via intermittent infusion.

Guidelines for Preventing Infections in Adolescent Athletes

Guidelines for Preventing Infections in Adolescent Athletes

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Many of the recommendations by sports organizations are more stringent than ordinary infection control practices for similar conditions.

FDA Approves Dose Modification for Children With HIV

FDA Approves Dose Modification for Children With HIV

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The FDA has approved labeling changes for Genvoya to include new safety and efficacy data.

Pediatric Outpatient Antimicrobial Stewardship: Minimizing Antibiotic Duration

Pediatric Outpatient Antimicrobial Stewardship: Minimizing Antibiotic Duration

Hear from experts on when to prescribe short course antibiotic therapy in pediatric populations for a variety of common infections.

FDA Expands Peramivir Injection for Children With Acute Uncomplicated Influenza

FDA Expands Peramivir Injection for Children With Acute Uncomplicated Influenza

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The has expanded the use of Rapivab to pediatric patients aged ≥2 years with acute uncomplicated influenza

Antibiotics Not Recommended in Pediatrics With Negative Rapid Strep Test Results

Antibiotics Not Recommended in Pediatrics With Negative Rapid Strep Test Results

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Pediatric patients with group A streptococcal pharyngitis should not be treated with antibiotics if results of an RADT are negative.

Clinic Visits, Costs Decreased by Rotavirus Vaccination in US Children

Clinic Visits, Costs Decreased by Rotavirus Vaccination in US Children

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An analysis of the financial burden associated with rotavirus infection revealed a lower cost burden for children receiving complete and incomplete vaccination relative to completely unvaccinated children.

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