Pneumonia

Serological Response to PCV13, PPV23 Vaccination Varies According to Individual Biologic in RA

Serological Response to PCV13, PPV23 Vaccination Varies According to Individual Biologic in RA

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The objective of the study was to evaluate initial serologic responses to the 13-valent protein-conjugated and the 23-valent polysaccharide pneumococcal vaccine.

Primary Prophylaxis Reduces Pneumocystis Pneumonia in Rheumatic Disease

Primary Prophylaxis Reduces Pneumocystis Pneumonia in Rheumatic Disease

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Prolonged treatment with high-dose steroids is a significant risk factor for pneumocystis pneumonia in patients with hematologic malignancies, solid organ transplants, and rheumatic diseases.

Increased Aspiration Pneumonia Risk Associated With Antipsychotic Use

Increased Aspiration Pneumonia Risk Associated With Antipsychotic Use

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The absolute risk for aspiration pneumonia attributable to antipsychotic exposure is much greater in older rather than younger adults.

Tools for Predicting Prolonged Hospitalization in Pediatric CAP

Tools for Predicting Prolonged Hospitalization in Pediatric CAP

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Pleural fluid lactic dehydrogenase and glucose are useful parameters in determining the severity of pediatric CAP.

Reduced Rate of Ventilator-Associated Pneumonia With Nebulized Antibiotics

Reduced Rate of Ventilator-Associated Pneumonia With Nebulized Antibiotics

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Prophylactic antibiotics delivered by nebulization in patients who were mechanically ventilated reduced the rate of ventilator-associated pneumonia

Combination β-lactam, Macrolide Pneumonia Therapy in Children Not More Effective

Combination β-lactam, Macrolide Pneumonia Therapy in Children Not More Effective

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The results of this study question the routine empirical use of macrolide combination therapy in this population.

Zoonotic Potential of <i>C caviae</i> Resulting in Severe CAP Described

Zoonotic Potential of C caviae Resulting in Severe CAP Described

Three cases of community-acquired pneumonia involving Chlamydia caviae after exposure to ill guinea pigs have been described

Universal Pneumonia Vaccine in Development

Universal Pneumonia Vaccine in Development

Preclinical tests show the new vaccine stimulated an immune response to 72 of the more than 90 known strains of S pneumoniae.

Increase in Long-Term Risk of Pneumonia With GERD

Increase in Long-Term Risk of Pneumonia With GERD

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Gastroesophageal reflux disease is associated with long-term risk of pneumonia in a younger population of patients treated with PPIs.

FDA: Priority Review Granted to Expand Indications for Ceftazidime/Avibactam

FDA: Priority Review Granted to Expand Indications for Ceftazidime/Avibactam

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The FDA has granted priority review for Avycaz (ceftazidime/avibactam) to expand the current indications.

Effect of Omadacycline on Cardiac Parameters in ABSSSI and CABP

Effect of Omadacycline on Cardiac Parameters in ABSSSI and CABP

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Omadacycline was non-inferior to moxifloxacin for treatment of CABP and linezolid for treatment of ABSSSI.

Antibiotic Regimen Strategy for Improving Severe Community-Acquired Pneumonia

Antibiotic Regimen Strategy for Improving Severe Community-Acquired Pneumonia

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Patients who seem to benefit most from the combination of a macrolide with a β-lactam are patients with bacteremic pneumococcal pneumonia, septic shock, and invasive mechanical ventilation.

Efficacy of Procalcitonin-Guided Antimicrobial Stewardship Initiative for Diagnosing Pneumonia

Efficacy of Procalcitonin-Guided Antimicrobial Stewardship Initiative for Diagnosing Pneumonia

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Implementation of a procalcitonin diagnostic algorithm improves diagnostic yield and reduces hospital length of stay in bacterial pneumonia.

Minorities With Low Income and Poor Education Receive Lower Uptake of PCV13

Minorities With Low Income and Poor Education Receive Lower Uptake of PCV13

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Multiple disparities exist in rates of adult vaccination for 13-valent pneumococcal conjugate vaccine.

Efficacy of Delafloxacin in Treating Community-Acquired Bacterial Pneumonia

Efficacy of Delafloxacin in Treating Community-Acquired Bacterial Pneumonia

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The efficacy of delafloxacin in treating Streptococcus pneumoniae, Haemophilius influenzae, and Moraxella catarrhalis isolates was examined.

Macrolides Superior to Beta-Lactams in Pediatric Community-Acquired Pneumonia

Macrolides Superior to Beta-Lactams in Pediatric Community-Acquired Pneumonia

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Macrolides, despite inferior anti-pneumococcal activity, are the most commonly prescribed antibiotic class for CAP in Children.

Updated Guidelines for Management of Hospital-Acquired/Ventilator-Associated Pneumonia

Updated Guidelines for Management of Hospital-Acquired/Ventilator-Associated Pneumonia

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An international panel of experts applied the GRADE system and choose 7 PICO questions to generate recommendations for HAP/VAP.

No Significant Difference in Community-Acquired Pneumonia Tx Outcomes in HIV Immunosuppression

No Significant Difference in Community-Acquired Pneumonia Tx Outcomes in HIV Immunosuppression

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Adults with community-acquired pneumococcal pneumonia who are HIV-immunosuppressed had the same prognosis and outcomes with standardized treatment.

Labored Breathing, Hypoxemia May Indicate Pneumonia in Children

Labored Breathing, Hypoxemia May Indicate Pneumonia in Children

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Difficulty breathing and hypoxemia may be a better indication of pneumonia in children.

Otopathogen Prevalence Altered Since Pneumococcal Vaccine Introduction

Otopathogen Prevalence Altered Since Pneumococcal Vaccine Introduction

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A new longitudinal study updates the epidemiology of acute otitis media in the decade after pneumococcal conjugate vaccine introduction.

Increased CVD Risk Persists for Years After Treatment for Sepsis or Pneumonia

Increased CVD Risk Persists for Years After Treatment for Sepsis or Pneumonia

Cardiovascular disease risks persist for years after sepsis or pneumonia.

Time to Blood Culture Positivity Predicts Pneumonia Severity and Outcome

Time to Blood Culture Positivity Predicts Pneumonia Severity and Outcome

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Time to blood culture positivity was directly associated with disease severity and outcomes in bacteremic pneumococcal pneumonia.

Increased Risk of Pneumococcal Infection Linked to Celiac Disease

Increased Risk of Pneumococcal Infection Linked to Celiac Disease

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Researchers conducted a systematic review of 3 manuscripts, including a total of 50,547 patients with celiac disease.

Risk of Cardiovascular Disease in Men With Sepsis, Pneumonia

Risk of Cardiovascular Disease in Men With Sepsis, Pneumonia

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Men who have sepsis or pneumonia have a higher risk of cardiovascular disease.

Clinical Update: Community-Acquired Pneumonia Following Sepsis

Clinical Update: Community-Acquired Pneumonia Following Sepsis

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The quick Sepsis-Related Organ Failure Assessment (qSOFA) clinical tool was superior to SIRS criteria for the evaluation of in-hospital mortality.

Chasing Serotype Replacement in Pneumococcal Pneumonia

Chasing Serotype Replacement in Pneumococcal Pneumonia

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Increasing rates of non-pneumococcal conjugate vaccine 13 serotypes of invasive pneumococcal disease present a new challenge to the global containment of the infection.

VZV-Related CAP Linked to Significant Mortality, Morbidity Rates

VZV-Related CAP Linked to Significant Mortality, Morbidity Rates

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Varicella-zoster virus-related community-acquired pneumonia can be linked to significant rates of morbidity and mortality in adults.

Challenges in Managing Hospital-Acquired Pneumonia

Challenges in Managing Hospital-Acquired Pneumonia

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Diagnosis is one of the primary difficulties in managing hospital acquired pneumonia.

Single-Dose PCV13 Immunogenic, Safe in Pediatric Oncology

Single-Dose PCV13 Immunogenic, Safe in Pediatric Oncology

A single-dose 13-valent pneumococcal conjugate vaccine (PCV13) was found to be safe and immunogenic for pediatric oncology patients.

Efficacy of Antibiotics for Community-Acquired Pneumonia Evaluated

Efficacy of Antibiotics for Community-Acquired Pneumonia Evaluated

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Study finds that over one-fifth of those prescribed an antibiotic for community-acquired pneumonia experience treatment failure.

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