Oral HPV Risk Substantially Reduced With HPV Vaccine

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Population-weighted prevalence of oral HPV16/18/6/11 infections was lower in vaccinated vs unvaccinated individuals.
Population-weighted prevalence of oral HPV16/18/6/11 infections was lower in vaccinated vs unvaccinated individuals.

HealthDay News — Human papillomavirus (HPV) vaccination appears to confer a high degree of protection from oral HPV infections, according to a study scheduled for presentation at the annual meeting of the American Society of Clinical Oncology, to be held from June 2 to 6 in Chicago.

Data from 2627 Americans, aged 18 to 33, were analyzed to assess the effect of self-reported receipt of at least one dose of an HPV vaccine on oral HPV infection (vaccine types 16/18/6/11) prevalence.

The researchers found that the population-weighted prevalence of oral HPV16/18/6/11 infections was significantly lower in vaccinated vs unvaccinated individuals (0.11% vs 1.61%; P = .008), which corresponded to an estimated 88.2% reduction in prevalence. For 33 non-vaccine HPV types, prevalence rates were similar (3.98% vs 4.74%; = 0.24).

"When we compared the prevalence in vaccinated men to non-vaccinated men, we didn't detect any infections in vaccinated men. The data suggest that the vaccine may be reducing the prevalence of those infections by as high as 100%," study author Maura Gillison, MD, PhD, a professor of thoracic/head and neck medical oncology at the University of Texas MD Anderson Cancer Center in Houston, said in a center news release. "But, unfortunately, because of low uptake of the vaccine, the burden of infection had only been reduced by 17% overall, and only 7% in men."

Gillison disclosed financial ties to several pharmaceutical companies.

Reference

HPV vaccination may reduce oral HPV infections- but still under-utilized [press release]. Alexandria, VA: American Society of Clinical Oncology. Published May 17, 2017. Accessed May 22, 2017.

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