Prevention

No benefit of negative pressure wound therapy for lower extremity open fractures

In this randomized controlled trial, there was no difference in the self-reported disability 12 months after injury between patients treated with negative pressure wound therapy (NPWT) and those treated with standard wound dressings.

Mavyret Labeling Updated With Dosing for Liver, Kidney Transplant Patients

Mavyret Labeling Updated With Dosing for Liver, Kidney Transplant Patients

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The Dosage and Administration section has been revised to state that Mavyret is recommended for 12 weeks in liver or kidney transplant recipients.

FDA Warns Against Long-Term Azithromycin Use for Some

FDA Warns Against Long-Term Azithromycin Use for Some

The FDA is warning patients with cancers of the blood or lymph nodes who undergo a donor stem cell transplant not to take azithromycin,

Infection Prevention Differs Between Small, Large Hospitals

Infection Prevention Differs Between Small, Large Hospitals

Small and large hospitals differ in infection preventionist (IP) staffing and infection prevention and control resources.

Drug treatment associated with a significant reduction in death risk following opioid overdose

Buprenorphine and methadone maintenance treatment (MMT) was associated with reduced death in opioid users.

Previous Missed Appointments Predict Likelihood of Trend in Patients With HIV

Previous Missed Appointments Predict Likelihood of Trend in Patients With HIV

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In a large, geographically diverse sample of patients engaged in routine HIV primary care, past HIV appointment attendance emerged as the most powerful predictor of future attendance.

International Antiviral Society-USA Updates Recommendations for HIV Treatment and Prevention

International Antiviral Society-USA Updates Recommendations for HIV Treatment and Prevention

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The International Antiviral Society-USA Panel has updated its recommendations for the management and prevention of HIV infection, to reflect the most current data on new treatment regimens and strategies.

More data needed to determine safety of probiotics and prebiotics

Studies are often lacking or inadequate with respect to reporting adverse events (AEs) related to probiotics and prebiotics.

Safety and Immunogenicity of Tdap Vaccine Immunization During Pregnancy

Safety and Immunogenicity of Tdap Vaccine Immunization During Pregnancy

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Immunization with Tdap vaccine during pregnancy results in higher levels of antibodies early in infancy but lower levels after the primary vaccine series.

Urine-Based <i>Strongyloides</i>-Specific ELISA Comparable to Serological Assay

Urine-Based Strongyloides-Specific ELISA Comparable to Serological Assay

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A urine-based assay for strongyloidiasis had a diagnostic accuracy comparable to the serological assay, and both perform better than coprological assays.

Measles Case Reported in Minnesota

Measles Case Reported in Minnesota

A Somali-American child in Minnesota has been diagnosed with the measles after returning from a trip to Africa.

Antibiotics Often Unnecessary for Sacral Pressure Ulcers Complicated by Osteomyelitis

Antibiotics Often Unnecessary for Sacral Pressure Ulcers Complicated by Osteomyelitis

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A systematic literature review, published in Clinical Infectious Diseases, found no evidence supporting a benefit to antibacterial therapy for osteomyelitis in patients with stage IV sacral pressure ulcers.

FDA Approves Omadacycline for Skin Infections, Pneumonia

FDA Approves Omadacycline for Skin Infections, Pneumonia

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The Committee's recommendation was based on data from the omadacycline global development program that included nearly 2000 adults in three Phase 3 studies.

Delays in Seeking Care, a Major Cause of Costly 2013 NYC Measles Outbreak

Delays in Seeking Care, a Major Cause of Costly 2013 NYC Measles Outbreak

Vaccine refusals and delays, particularly in young children, fueled a large measles outbreak following importation of a case into the United States.

Addressing Motivations That May Drive PrEP Appeal in MSM

Addressing Motivations That May Drive PrEP Appeal in MSM

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A new theoretical model of understanding (PrEP) use intention in MSM highlights the complexity of decision-making about PrEP in MSM while providing insights into strategies for effective intervention.

Several Invasive Procedures Linked to Infective Endocarditis

Several Invasive Procedures Linked to Infective Endocarditis

Several invasive medical procedures, including cardiovascular procedures and procedures of the skin and management of wounds, are associated with increased risk of infective endocarditis.

Inappropriate Antibiotic Prescriptions Highest Among Urgent Care Facilities

Inappropriate Antibiotic Prescriptions Highest Among Urgent Care Facilities

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Inappropriate antibiotic prescriptions were highest among urgent care facilities (45.7%), with emergency departments (24.6%), medical offices (17.0%), and retail clinics (14.4%) following.

Ciprofloxacin May Increase Likelihood of Aortic Dissection, Rupture

Ciprofloxacin May Increase Likelihood of Aortic Dissection, Rupture

In a mouse model of moderate, sporadic aortic aneurysm and dissection (AAD), ciprofloxacin increases susceptibility to aortic dissection and rupture.

Some Bacteria Now More Tolerant of Alcohol-Based Sanitizers

Some Bacteria Now More Tolerant of Alcohol-Based Sanitizers

Some types of bacteria are developing tolerance of alcohol-based hand sanitizers used in hospitals.

Integrating Treatments for Opioid Use Disorder and Infectious Diseases

Integrating Treatments for Opioid Use Disorder and Infectious Diseases

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All healthcare providers have a role in combating the opioid use disorder epidemic and its infectious disease consequences.

Continuing, Switching TNFi After Serious Infection Reduces Likelihood of Recurrent Infection

Continuing, Switching TNFi After Serious Infection Reduces Likelihood of Recurrent Infection

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Patients who continued or switched their TNF inhibitor after a serious infection had a lower risk for recurrent infection compared with those who stopped the drug.

Flu Vaccine Cuts Mortality in Rheumatoid Arthritis Patients

Flu Vaccine Cuts Mortality in Rheumatoid Arthritis Patients

Patients with rheumatoid arthritis, particularly elderly patients, who receive the influenza vaccine have significantly lower morbidity and mortality.

Increasing Incidence of Staphylococcal Scalded Skin Syndrome in the United States

Increasing Incidence of Staphylococcal Scalded Skin Syndrome in the United States

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Staphylococcal scalded skin syndrome is associated with substantial patient morbidity and costs.

Evidence Exists for Persistence, Transmission of Ebola Virus

Evidence Exists for Persistence, Transmission of Ebola Virus

Outbreak report describes transmission of Ebola virus one year after survival of Ebola virus disease.

Interleukin-8 Enhances Diagnosis of Invasive Aspergillosis in High-Risk Patients

Interleukin-8 Enhances Diagnosis of Invasive Aspergillosis in High-Risk Patients

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High serum levels of IL-8 were highly specific and showed high sensitivity when combined with either the BALF, LFD, or BALF Aspergillus PCR, for differentiating probable invasive aspergillosis from cases with no infection.

Infective Endocarditis More Common With Bicuspid Aortic Valve, Mitral Valve Prolapse

Infective Endocarditis More Common With Bicuspid Aortic Valve, Mitral Valve Prolapse

Individuals with bicuspid aortic valve and mitral valve prolapse have a higher risk of developing infective endocarditis (IE) than the general population.

Safety and Immunogenicity of Group A Streptococcus Vaccine Candidate MJ8VAX

Safety and Immunogenicity of Group A Streptococcus Vaccine Candidate MJ8VAX

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Intramuscular administration of a novel group A streptococcus vaccine candidate (MJ8VAX) was demonstrated to be safe and immunogenic.

Could Zika Virus Be a Potential Treatment for Neuroblastoma?

Could Zika Virus Be a Potential Treatment for Neuroblastoma?

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Even with intensive therapy, survival among neuroblastoma patients is poor, indicating a need for alternative treatments.

FDA Advisory Committee Votes in Favor of Tafenoquine for Malaria Prevention

FDA Advisory Committee Votes in Favor of Tafenoquine for Malaria Prevention

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In clinical trials, tafenoquine, an 8-aminoquinoline, demonstrated efficacy against 2 primary types of malaria, Plasmodium vivax and P. falciparum malaria.

Insight Into the HIV Self-Testing Debate

Insight Into the HIV Self-Testing Debate

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Although the CDC recommends routine HIV screening for all people age 13-64 years, numerous barriers to HIV testing in healthcare settings have been identified, including lack of access and fear of stigma and discrimination.

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