Prevention

Review of <i>Clostridium difficile</i> Vaccines in Development

Review of Clostridium difficile Vaccines in Development

Drs Kociolek and Shulman, from the division of infectious diseases at the Ann & Robert H. Lurie Children's Hospital of Chicago in Illinois, review all the current vaccine candidates in development for Clostridium difficile infection.

Influenza Vaccine Safe During Any Trimester of Pregnancy

Influenza Vaccine Safe During Any Trimester of Pregnancy

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Researchers found that the influenza vaccine, when given to pregnant women, does not affect weeks' gestation of the infant at birth or the infant's birth weight.

FDA: QDIP Status for Post-Surgical Sternal Infection Antibiotic Reservoir

FDA: QDIP Status for Post-Surgical Sternal Infection Antibiotic Reservoir

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The FDA has granted Qualified Infectious Disease Product (QIDP) to D-PLEX (Doxycycline/Polymer-Lipid Encapsulation Matrix; PolyPid), a secured antibiotic drug reservoir for the local prevention and treatment of surgical infections.

Reducing Antibiotic Use in Infants With Use of Sepsis Risk Calculator

Reducing Antibiotic Use in Infants With Use of Sepsis Risk Calculator

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A study finds the use of early-onset sepsis calculator can decrease the number of infants receiving a sepsis work-up and prophylactic antibiotics.

Patients' Expectations for Antibiotics Encourage Overprescribing

Patients' Expectations for Antibiotics Encourage Overprescribing

Study finds physicians overprescribe antibiotics to accommodate patient expectations.

Plague Vaccine Granted Orphan Drug Designation

Plague Vaccine Granted Orphan Drug Designation

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FDA has granted Orphan Drug designation to the recombinant rF1V plague vaccine for pre-exposure prophylaxis of Yersinia pestis infection, also known as, the plague.

Immunity Persists for Ebola Vaccines at One Year

Immunity Persists for Ebola Vaccines at One Year

A strategy of preemptive use of an AD26.ZEBOV followed by MVA-BN-Filo immunization schedule in at-risk populations may offer advantages over reactive use of single-dose vaccine regimens.

Reducing CVD Risk Using a Vaccine-Based Approach

Reducing CVD Risk Using a Vaccine-Based Approach

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In preclinical animal studies, vaccination against PSCK9 lowered serum lipids and vaccination against ApoC3 lowered serum triglyceride levels.

Is CMV a Major Contributor to Cardiovascular Disease in RA?

Is CMV a Major Contributor to Cardiovascular Disease in RA?

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An expert Q&A with Florian Kern, PhD, deputy director of research at Brighton and Sussex Medical School in the UK, who makes the case that cytomegalovirus is a major driver of cardiovascular disease in patients with rheumatoid arthritis.

Lower Use of STD Services in Young Adults Due to Confidentiality Issues

Lower Use of STD Services in Young Adults Due to Confidentiality Issues

Sexually active teens reported to not to seek out STD services due to confidentiality issues.

Decrease in Pneumococcal Bacteremia With Routine PCV13 Vaccine

Decrease in Pneumococcal Bacteremia With Routine PCV13 Vaccine

Researchers observed a 95.3% reduction of S pneumoniae bacteremia after implementation of routine immunization with the pneumococcal conjugate vaccine.

NIH: Respiratory Syncytial Virus Vaccine Testing Begins

NIH: Respiratory Syncytial Virus Vaccine Testing Begins

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At this time, no vaccine to prevent or drug to treat respiratory syncytial virus infection is available.

Investigational Malaria Vaccine Shows Durable Response to Multiple Strains

Investigational Malaria Vaccine Shows Durable Response to Multiple Strains

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3 IV doses of PfSPZ vaccine conferred protection after immunization against different Pf strains of malaria than the one the vaccine came from.

NIH Begins Study on a Universal Mosquito-Borne Diseases Vaccine

NIH Begins Study on a Universal Mosquito-Borne Diseases Vaccine

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Investigational vaccine is designed to trigger an immune response to mosquito saliva rather than to a specific virus or parasite carried by mosquitoes.

VZV Vaccine Promising in Immunocompromised Patients With Herpes Zoster

VZV Vaccine Promising in Immunocompromised Patients With Herpes Zoster

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Phase 3 study looked at the safety, tolerability, efficacy, and immunogenicity of inactivated VZV Vaccine in recipients of auto-HSCT.

Intramuscular Flu Vaccination Recommended for Patients With Eczema

Intramuscular Flu Vaccination Recommended for Patients With Eczema

Patients with atopic dermatitis with S aureus had reduced immune response to intradermal influenza vaccination but not intramuscular vaccination.

High-Dose Influenza Vaccine in H3N2 Season More Effective in Seniors

High-Dose Influenza Vaccine in H3N2 Season More Effective in Seniors

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Compared to infections by H1N1 or influenza B viruses, H3N2 influenza viruses have been associated with higher mortality in older adults.

Macrophages Play a Role in Protecting Alveolar Epithelial Cells Against IAV

Macrophages Play a Role in Protecting Alveolar Epithelial Cells Against IAV

The cysteinyl leukotriene pathway may be a therapeutic target in future research preventing morbidity associated with severe influenza A virus infection.

Quadrivalent Influenza Vaccine Found to be Safe

Quadrivalent Influenza Vaccine Found to be Safe

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No safety signals associated with the administration of quadrivalent live attenuated influenza vaccine were observed, according to a large population study.

Efficacy of 23-Valent Pneumococcal Vaccine in Rheumatoid Arthritis Questioned

Efficacy of 23-Valent Pneumococcal Vaccine in Rheumatoid Arthritis Questioned

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A prospective, multicenter, randomized, placebo-controlled trial evaluates efficacy of the 23-valent pneumococcal polysaccharide vaccine in preventing pneumonia in patients with rheumatoid arthritis.

CDC Reports on Seasonal Influenza Vaccine Effectiveness

CDC Reports on Seasonal Influenza Vaccine Effectiveness

For the predominant circulating influenza A type H3N2 flu strain, the vaccine effectiveness comes in at 43%.

Lower Rates of Recurrent <i>C difficile</i> Infections With Bezlotoxumab

Lower Rates of Recurrent C difficile Infections With Bezlotoxumab

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Bezlotoxumab was particularly effective in patients with risk factors for poor outcome, including older age, immunocompromise, and severe infection.

Restricting Fluoroquinolone Use Helped With CDI Decline in England

Restricting Fluoroquinolone Use Helped With CDI Decline in England

The outbreak of Clostridium difficile in England that began in 2006 was curbed by reducing the use of fluoroquinolones, according to a study.

Respiratory Vaccination Reduces Heart Failure Outcomes

Respiratory Vaccination Reduces Heart Failure Outcomes

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Vaccination may be able to prevent significant morbidity and mortality associated with heart failure, according to a study.

Efficacy of Antibiotic Prescribing Interventions in Hospitals Assessed

Efficacy of Antibiotic Prescribing Interventions in Hospitals Assessed

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Interventions used to help physicians prescribe antibiotics properly were effective at raising compliance with antibiotic policy and decreasing the duration of treatment, according to a Cochrane review.

ACIP Issues 2017 Updated Immunization Schedule

ACIP Issues 2017 Updated Immunization Schedule

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The Advisory Committee on Immunization Practices has issued updated 2017 immunization schedules for for children, adolescents, and adults.

Intrapartum Azithromycin Decreases Maternal, Neonatal Infections

Intrapartum Azithromycin Decreases Maternal, Neonatal Infections

Azithromycin given to women in labor decreases infections in both women and newborns during the puerperal period.

AAP: Better Strategies Needed to Increase Adolescent Vaccination Rates

AAP: Better Strategies Needed to Increase Adolescent Vaccination Rates

According to the American Academy of Pediatrics, HPV and influenza immunization rates remain well below the Healthy People 2020 goals.

Quadracel Vaccine Now Available in the US

Quadracel Vaccine Now Available in the US

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Quadracel was approved for active immunization against diphtheria, tetanus, pertussis and poliomyelitis in children aged 4 to 6 years old.

Strategies for Reducing Hospital-Acquired Infections

Strategies for Reducing Hospital-Acquired Infections

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Study finds that patients were 10% to 30% less likely to acquire a multidrug-resistant organism or C difficile if enhanced disinfection strategies were used in hospitals.

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