Sepsis

New York State Mandate for Pediatric Sepsis Bundled Care Linked to Lower Mortality

New York State Mandate for Pediatric Sepsis Bundled Care Linked to Lower Mortality

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Completion of a care bundle for pediatric patients within 1 hour of sepsis recognition, which includes blood cultures, broad-spectrum antibiotics, and a 20-mL/kg intravenous fluid bolus, was associated with lower in-hospital mortality among children with sepsis and septic shock

Presenting With Vague Symptoms May Increase Septic Shock Mortality Risk

Presenting With Vague Symptoms May Increase Septic Shock Mortality Risk

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A large proportion of patients with septic shock but who present to the ED with vague symptoms not specific to infection have a significantly higher mortality rate than those with symptoms that are explicit to an infection.

Quick Sequential Organ Failure Assessment Score Effectively Identifies Patients With High Mortality Risk

Quick Sequential Organ Failure Assessment Score Effectively Identifies Patients With High Mortality Risk

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qSOFA score can identify patients with suspected infection, who are at a higher risk for excess hospital mortality.

Prognostic Biomarkers to Guide Antibiotic Therapy in Critically Ill Patients

Prognostic Biomarkers to Guide Antibiotic Therapy in Critically Ill Patients

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Proadrenomedullin and procalcitonin have demonstrated superiority to C-reactive protein for predicting mortality and guiding antimicrobial therapy in critically ill patients with fever.

Delays in Lactate Testing Associated With Delayed Antibiotics, Increased Mortality in Sepsis

Delays in Lactate Testing Associated With Delayed Antibiotics, Increased Mortality in Sepsis

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Delayed lactate measurement is associated with delayed antibiotic administration and increased mortality in patients with increased lactate levels.

Sepsis-3 Septic Shock Criteria vs SIRS to Predict Mortality in Hospitalized Patients

Sepsis-3 Septic Shock Criteria vs SIRS to Predict Mortality in Hospitalized Patients

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Although the Systemic Inflammatory Response Syndrome criteria have been used for decades to identify sepsis in patients with suspected infection, they have been re-evaluated in the Third International Consensus Definitions for Sepsis and Septic Shock.

IV Drug Use Associated With Increased Mortality in Septic Arthritis

IV Drug Use Associated With Increased Mortality in Septic Arthritis

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The percentage of patients with septic arthritis related to opioid or injection drug use was found to have increased from 2000 to 2013.

 Case Volume Affects Sepsis Mortality in Immunosuppressed Patients

Case Volume Affects Sepsis Mortality in Immunosuppressed Patients

Risk of death from sepsis increased at hospitals with lowest volume of immunosuppressed patients with sepsis.

Delay of Lactate Draws in Sepsis Ups Risk of In-Hospital Death

Delay of Lactate Draws in Sepsis Ups Risk of In-Hospital Death

Systematic early lactate measurements speed antibiotic administration, improve outcomes.

Procalcitonin Is Effective Biomarker for Guiding Antibiotic Treatment in Sepsis

Procalcitonin Is Effective Biomarker for Guiding Antibiotic Treatment in Sepsis

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Researchers conducted a literature review to assess the effectiveness and safety of procalcitonin to guide treatment in patients with known or suspected sepsis.

Early Flow Cytometry Predictive of Clinical Deterioration in Sepsis

Early Flow Cytometry Predictive of Clinical Deterioration in Sepsis

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Increased circulating immature granulocytes at the acute phase of sepsis are linked to clinical worsening, especially when associated with T-cell lymphopenia.

Molecular Laboratory Test Can Discriminate Sepsis From Noninfectious SIRS

Molecular Laboratory Test Can Discriminate Sepsis From Noninfectious SIRS

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The SeptiCyteTM LAB may be an effective complementary diagnostic tool to clinical assessment of critically ill adult patients in discriminating between sepsis and noninfectious systemic inflammation syndrome.

Best Diagnosis for Sepsis May Be a 2-Step Approach With qSOFA and SIRS

Best Diagnosis for Sepsis May Be a 2-Step Approach With qSOFA and SIRS

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The association of both criteria (qSOFA and SIRS) could provide a better model to initiate or escalate therapy in patients with sepsis.

Infections Complicating the Use of Monoclonal Antibodies for Malignancy

Infections Complicating the Use of Monoclonal Antibodies for Malignancy

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In this review, David C. Helfgott, MD, editorial advisory board member for Infectious Disease Advisor, focuses on infectious complications from the use of monoclonal antibodies for malignancy.

How Important Is the Timing of Antibiotics for Surviving Sepsis?

How Important Is the Timing of Antibiotics for Surviving Sepsis?

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Early antibiotic administration in treating infection has evident biological plausibility, however, time-sensitivity to outcomes appears to be most relevant in septic shock.

Delayed Management of Severe Sepsis, Septic Shock Increases Mortality

Delayed Management of Severe Sepsis, Septic Shock Increases Mortality

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Study demonstrated a new approach to incorporate time ("delay") when analyzing the effect on outcomes and provided new evidence for clinical practice and research of severe sepsis or septic shock.

Arterial Lactate Level a Reliable Prognostic Predictor for Septic Shock

Arterial Lactate Level a Reliable Prognostic Predictor for Septic Shock

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Researchers evaluated the prognostic significance of the cutoff value for lactate via comparison of clinical presentation and outcome between patients with septic shock with high and low lactate levels.

Insulin-Treated Diabetes Reduces Dysglycemia-Related Mortality in Sepsis

Insulin-Treated Diabetes Reduces Dysglycemia-Related Mortality in Sepsis

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In patients with insulin-treated diabetes and sepsis, increased highest glucose levels and glycemic variability have a significant illness severity-adjusted association with decreasing in-hospital mortality.

When to Suspect GBS Cellulitis and Necrotizing Fasciitis in Infants

When to Suspect GBS Cellulitis and Necrotizing Fasciitis in Infants

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GBS infections in infants, cellulitis and necrotizing fasciitis, although uncommon in infants, requires swift treatment with antibiotics and occasionally surgical debridement.

Sepsis Calculator Reduces Antibiotic Therapy for Suspected Early-Onset Sepsis

Sepsis Calculator Reduces Antibiotic Therapy for Suspected Early-Onset Sepsis

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Implementation of the sepsis calculator in daily clinical decision-making may be feasible in conjunction with existing protocols, with high adherence.

Hydrocortisone Plus Fludrocortisone Lowers Mortality in Septic Shock

Hydrocortisone Plus Fludrocortisone Lowers Mortality in Septic Shock

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In this study involving patients with septic shock, 90-day all-cause mortality was lower in patients who received hydrocortisone plus fludrocortisone than in patients who received placebo.

Sepsis-Related Brain Dysfunction Linked to Gut Bacteria

Sepsis-Related Brain Dysfunction Linked to Gut Bacteria

Gut bacteria may be tied to sepsis-related brain dysfunction.

T2Candida May Shorten Time to <i>Candida</i> Detection, Species Identification

T2Candida May Shorten Time to Candida Detection, Species Identification

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Researchers validated the clinical sensitivity of the T2Candida panel for the diagnosis of bloodstream infections caused by the 5 most common pathogenic Candida species.

Sepsis Recovery Requires an All-Hands Approach

Sepsis Recovery Requires an All-Hands Approach

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After hospital discharge for sepsis, the healthcare team should focus on identifying new functional, mental, and cognitive impairments and referring patients to appropriate treatment; reviewing and adjusting long-term medications; and evaluating for treatable conditions that commonly result in hospitalizations.

Hydrocortisone plus fludrocortisone decreases mortality in adults with septic shock

Patients with septic shock in the intensive care unit undergoing mechanical ventilation receiving hydrocortisone plus fludrocortisone had a lower 90-day all-cause mortality compared to placebo treated patients.

Adjunctive glucocorticoid therapy does not lower mortality in septic shock

Patients with septic shock in the intensive care unit (ICU) undergoing mechanical ventilation and managed with adjunctive continuous hydrocortisone infusion, did not have a lower 90-day mortality compared to placebo.

Vaginal Dysbiosis Increases Risk for Preterm Fetal Membrane Rupture

Vaginal Dysbiosis Increases Risk for Preterm Fetal Membrane Rupture

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Vaginal microbiota composition is a risk factor for subsequent preterm prelabor rupture of the fetal membranes and is associated with adverse short-term maternal and neonatal outcomes.

Negative Fluid Balance Associated With Lower Influenza Mortality in the ICU

Negative Fluid Balance Associated With Lower Influenza Mortality in the ICU

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Findings indicate the critical role of conservative fluid strategy in the management of patients with complicated influenza.

Does the SEP-1 Bundle Improve Survival in Sepsis?

Does the SEP-1 Bundle Improve Survival in Sepsis?

Use of the SEP-1 Bundle or its hemodynamic interventions is not associated with improved survival in patients with sepsis.

Increased Risk of Serious Infections With Type 1 Diabetes

Increased Risk of Serious Infections With Type 1 Diabetes

Organ systems where bacterial infections predominate as well as fungal diseases were associated with substantial increases in magnitude among patients with both T1D and T2D, but risks were consistently higher for T1D.

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