Researchers evaluated the prognostic significance of the cutoff value for lactate via comparison of clinical presentation and outcome between patients with septic shock with high and low lactate levels.
In patients with insulin-treated diabetes and sepsis, increased highest glucose levels and glycemic variability have a significant illness severity-adjusted association with decreasing in-hospital mortality.
In this study involving patients with septic shock, 90-day all-cause mortality was lower in patients who received hydrocortisone plus fludrocortisone than in patients who received placebo.
Patients with septic shock in the intensive care unit undergoing mechanical ventilation receiving hydrocortisone plus fludrocortisone had a lower 90-day all-cause mortality compared to placebo treated patients.
Patients with septic shock in the intensive care unit (ICU) undergoing mechanical ventilation and managed with adjunctive continuous hydrocortisone infusion, did not have a lower 90-day mortality compared to placebo.
Induced hypothermia (target temperature 32°C-34°C) proved harmful with regards to respiratory function and it also prolonged septic shock.
Adjunctive glucocorticoid therapy in patients with septic shock may reduce the duration of shock.
Stanford T. Shulman, MD, editorial advisory board member for Infectious Disease Advisor, outlines reasons why IDSA elected not to endorse the 2016 Surviving Sepsis Campaign Guidelines.
Asthma patients with infections have a reduced risk of developing sepsis.
A patient who recently acquired a new tattoo developed Vibrio vulnificus septic shock after swimming in seawater, leading to death.
Three multicenter trials (ProCESS, ARISE, and ProMISe) showed that EGDT did not reduce mortality in patients presenting to the emergency department with septic shock when compared to usual care.
Hospitals see higher rate of in-hospital mortality from septic shock after norepinephrine shortage.
Researchers did not observe a significant improvement with hydrocortisone over placebo for time until septic shock or mortality.
Sign Up for Free e-newsletters
Infectious Disease Advisor Articles
- Generic HIV Medicines: Boon or Bust?
- Insulin-Treated Diabetes Reduces Dysglycemia-Related Mortality in Sepsis
- Pregnancy May Be Independently Associated With Prolonged Detection of Zika Virus RNA
- It Costs $2.2 Billion a Year to Treat Antibiotic Resistance
- Tricyclic Antidepressants May Reduce Cirrhosis Risk in Hepatitis C
- Fingerstick Point-of-Care Test Allows for Single-Visit HCV Diagnoses
- Clostridium difficile Infection in the Intensive Care Setting
- Combating Medically Important Antibiotic Use in Food-Producing Animals
- Religious Exemptions vs Mandatory Vaccinations: An Expert Perspective
- 2018 Vaccination Schedule: Adults
- Efficacy of Adjuvanted vs Conventional Quadrivalent Flu Vaccine Compared
- Glecaprevir/Pibrentasvir Highly Efficacious for HCV/HIV Coinfection
- Fluoroquinolone Use May Increase Risk for Aortic Aneurysm and Dissection
- Reduced Risk of Hepatocellular Carcinoma in DAA-Treated HCV Infection
- Paracetamol Overuse During Cold and Flu Season