No Difference in Herpes Zoster Risk With Biologic- vs Nonbiologic-Treated Psoriasis

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No significant differences were seen between those receiving no systemic therapy, any systemic therapy, biologics only, nonbiologics only, or a combination therapy.
No significant differences were seen between those receiving no systemic therapy, any systemic therapy, biologics only, nonbiologics only, or a combination therapy.

HealthDay News — For patients with psoriasis, the risk of herpes zoster (HZ) is not significantly increased for systemically treated patients or for those receiving biologics vs nonbiologics, according to a research letter published in JAMA Dermatology.

Katherine A. Levandoski, from Massachusetts General Hospital in Boston, and colleagues estimated the incidence of HZ among systemically treated patients with psoriasis from 1998 to 2011, comparing patients treated with biologics vs nonbiologics.

The researchers found that of the 5889 participants with systemically treated psoriasis, 291 had HZ diagnosed during a mean follow-up of 5.3 person-years. 

The crude incidence rates showed that the risk of HZ was increased, although not statistically significantly so, for those on systemic therapy vs no systemic therapy at the time of HZ diagnosis (incidence rate, 10.2 vs 8.6; P = 0.14). No significant differences were seen between those receiving no systemic therapy, any systemic therapy, biologics only, nonbiologics only, or a combination therapy, after adjustment for age and sex (adjusted incidence rates, 6.1, 8.1, 7.8, 8.9, and 5.6, respectively).

"We found no significant differences in HZ risk at time of HZ diagnosis among those treated with systemic therapy vs no systemic therapy, and among systemically treated patients, among those treated with biologics vs no biologic agents," the authors write.

Two authors disclosed financial ties to pharmaceutical companies, including Pfizer, which partially funded the study.

Reference

Levandoski KA, Quesenberry CP, Tsai AL, et al. Herpes Zoster rates in a large cohort of patients with systemically treated psoriasis [published online December 20, 2017]. JAMA Dermatol. doi: 10.1001/jamadermatol.2017.4840

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