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Safety of Clofazimine in Treating Children With Mycobacterium abscessus Infections

Safety of Clofazimine in Treating Children With Mycobacterium abscessus Infections

Clofazimine was safe and well-tolerated as part of a multidrug regimen for the treatment of children with Mycobacterium abscessus odontogenic infections.

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Priority Review Granted for Treatment of Complicated UTI, Bloodstream Infections

Priority Review Granted for Treatment of Complicated UTI, Bloodstream Infections

The FDA accepted a new drug application for plazomicin for complicated urinary tract infections.

Reducing Treatment of HPV+ Oropharyngeal Cancer May Compromise Safety

Reducing Treatment of HPV+ Oropharyngeal Cancer May Compromise Safety

Deintensification of treatment from chemoradiotherapy to one modality may compromise safety in patients with human papillomavirus (HPV)+ stage 1 or 2 oropharyngeal cancer.

Diclofenac Inferior to Norfloxacin for UTI, May Increase Pyelonephritis Risk

Diclofenac Inferior to Norfloxacin for UTI, May Increase Pyelonephritis Risk

The benefit of antibiotic treatment needs to be weighed against the potential for adverse effects, at both the individual level (adverse drug reactions) and the population level (as a driver of antibiotic resistance).

First Oral Smallpox Treatment Submitted to FDA for NDA

First Oral Smallpox Treatment Submitted to FDA for NDA

A new drug application was submitted to the FDA for oral formula to treat smallpox.

Diclofenac Inferior to Norfloxacin for UTI Symptom Relief

Diclofenac Inferior to Norfloxacin for UTI Symptom Relief

NSAIDs were found to be inferior to antibiotics for symptom relief of uncomplicated urinary tract infection.

Fixed-Dose Meropenem-Vaborbactam Available for Complicated UTI, Pyelonephritis

Fixed-Dose Meropenem-Vaborbactam Available for Complicated UTI, Pyelonephritis

Vabomere is now available for the treatment of adults (≥18 years old) with complicated urinary tract infections.

Secnidazole Efficacious in Treatment of Bacterial Vaginosis

Secnidazole Efficacious in Treatment of Bacterial Vaginosis

Secnidazole is a 5-nitroimidazole with demonstrated in vitro antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species, while sparing Lactobacillus species.

New Guidelines Show Best Practices for H pylori Treatment

New Guidelines Show Best Practices for H pylori Treatment

Three new guidelines discuss the best practice for Helicobacter pylori treatment.

IV Penicillin Safety in Those With Allergy History But Negative Skin Test

IV Penicillin Safety in Those With Allergy History But Negative Skin Test

Repeated intravenous administration of penicillin antibiotics appears to be safe in patients with a reported penicillin allergy and a negative penicillin allergy test.

Guideline-Adherent Antibiotics Decrease Readmission for Acute Chest Syndrome

Guideline-Adherent Antibiotics Decrease Readmission for Acute Chest Syndrome

Researchers believe implementation of treatment guidelines for children with sickle cell disease with acute chest syndrome may decrease hospital readmission rates.

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