Treatments

Antipseudomonal Monotherapy Efficacious in Pneumonia

Antipseudomonal Monotherapy Efficacious in Pneumonia

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Antipseudomonal combination therapy has shown poorer efficacy than antipseudomonal monotherapy in individuals with suspected pseudomonal pneumonia.

Baloxavir Marboxil Safe and Effective for High-Risk Influenza Patients

Baloxavir Marboxil Safe and Effective for High-Risk Influenza Patients

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When compared to placebo, baloxavir marboxil was associated with reduced risk of influenza complications and faster recovery.

Sustained Hepatitis C Treatment Associated With Lower Risk for Cardiovascular Events

Sustained Hepatitis C Treatment Associated With Lower Risk for Cardiovascular Events

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Treatment for hepatitis C is associated with a reduction in cardiovascular events.

Antibiotic Stewardship May Aid Stepdown Therapies for Community-Acquired Pneumonia

Antibiotic Stewardship May Aid Stepdown Therapies for Community-Acquired Pneumonia

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The use of fluoroquinolones in stable patients with community-acquired pneumonia can be reduced with stewardship programs that share antibiotic use data and provide guidance for step-down therapy.

Oral Ciprofloxacin Effective in Treatment for Bacteremia

Oral Ciprofloxacin Effective in Treatment for Bacteremia

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Oral ciprofloxacin has been found to be an effective option for gram-negative bacteremia treatment.

CYP2D6 Enzymatic Activity May Increase Primaquine Malaria Treatment Efficacy

CYP2D6 Enzymatic Activity May Increase Primaquine Malaria Treatment Efficacy

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A natural variability of genotype-determined, CYP2D6-dependent metabolism of primaquine phosphate is associated with an increased risk of failure in the treatment of P vivax malaria.

Short Course Primaquine Regimens for <i>P vivax</i> Malaria Improves Treatment Efficacy

Short Course Primaquine Regimens for P vivax Malaria Improves Treatment Efficacy

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Chloroquine with either 7- or 14-day primaquine regimens provided highly effective radical cure of vivax malaria on the Thailand-Myanmar border.

Corticosteroid Use May Modestly Reduce Mortality Risk in Sepsis

Corticosteroid Use May Modestly Reduce Mortality Risk in Sepsis

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The use of corticosteroids in sepsis appears to modestly reduce the risk for death and modestly increase neuromuscular weakness but the evidence is not definitive.

Ibalizumab, a Treatment Option for Multidrug Resistant HIV-1 Infection

Ibalizumab, a Treatment Option for Multidrug Resistant HIV-1 Infection

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Ibalizumab showed significant antiviral activity in patients with multidrug-resistant HIV-1 infection, advanced disease, and few other treatment options

Individualized Treatment of Late Acute Prosthetic Joint Infection May Decrease Failure Rate

Individualized Treatment of Late Acute Prosthetic Joint Infection May Decrease Failure Rate

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Treatment strategies for late acute prosthetic joint infections should be individualized according to patients' age, comorbidities, clinical presentation, and microorganism causing the infection.

Relapse-Free Cure From MDR-TB Higher Than Anticipated

Relapse-Free Cure From MDR-TB Higher Than Anticipated

The frequency of relapse-free cure from multidrug-resistant tuberculosis is higher than previously anticipated.

Minimum Inhibitory Concentration of Isoniazid, Rifampin May Predict TB Relapse

Minimum Inhibitory Concentration of Isoniazid, Rifampin May Predict TB Relapse

Higher MIC in pretreatment M. tuberculosis isolates linked to relapse risk.

Two Ebola Patients Who Received Experimental Treatment Have Recovered

Two Ebola Patients Who Received Experimental Treatment Have Recovered

Two of the first 10 people to receive an experimental Ebola treatment have recovered from the highly dangerous disease.

Smartphone App Can Help Improve Outcomes in Patients With HIV

Smartphone App Can Help Improve Outcomes in Patients With HIV

Improvements seen in retention in care, CD4 counts, and viral suppression.

Generic Substitutes, Therapeutic Interchange Can Save Money

Generic Substitutes, Therapeutic Interchange Can Save Money

Considerable savings estimated with use of generic substitutes for brand-name combo medications.

Similar Safety and Efficacy for Rifampin vs Isoniazid in Children, Adolescents

Similar Safety and Efficacy for Rifampin vs Isoniazid in Children, Adolescents

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For children younger than 18 years, 4 months of rifampin to treat latent Mycobacterium tuberculosis had similar rates of safety and efficacy and higher rates of adherence compared with 9 months of isoniazid.

AHA Issues Scientific Statement on Managing Chagas Cardiomyopathy

AHA Issues Scientific Statement on Managing Chagas Cardiomyopathy

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The most common findings in patients with Chagas cardiomyopathy include cardiac rhythm abnormalities, myocardial abnormalities, aneurysms, and thromboembolism.

Antibiotics Often Unnecessary for Sacral Pressure Ulcers Complicated by Osteomyelitis

Antibiotics Often Unnecessary for Sacral Pressure Ulcers Complicated by Osteomyelitis

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A systematic literature review, published in Clinical Infectious Diseases, found no evidence supporting a benefit to antibacterial therapy for osteomyelitis in patients with stage IV sacral pressure ulcers.

Addressing Motivations That May Drive PrEP Appeal in MSM

Addressing Motivations That May Drive PrEP Appeal in MSM

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A new theoretical model of understanding (PrEP) use intention in MSM highlights the complexity of decision-making about PrEP in MSM while providing insights into strategies for effective intervention.

Guidelines for ART Updated for Those With or at Risk for HIV

Guidelines for ART Updated for Those With or at Risk for HIV

ART recommended for almost all HIV-infected; should be initiated as soon as possible post diagnosis.

Is Short-Course Antibiotic Treatment for CAP Effective?

Is Short-Course Antibiotic Treatment for CAP Effective?

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To investigate what impact antibiotic treatment duration has on CAP outcomes, researchers from the Warren Alpert Medical School of Brown University conducted a search of various databases for studies comparing the safety and efficacy of treatment regimens lasting ≤6 days (short) and ≥7 days (long).

Fixed-Dose Bictegravir, Emtricitabine, Tenofovir Alafenamide Is Efficacious HIV-1 Treatment Option

Fixed-Dose Bictegravir, Emtricitabine, Tenofovir Alafenamide Is Efficacious HIV-1 Treatment Option

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The fixed-dose combination of bictegravir, emtricitabine, and tenofovir alafenamide might provide a safe and efficacious option for ongoing treatment of HIV-1 infection

FDA Strengthens Warnings for Fluoroquinolone Antibiotics

FDA Strengthens Warnings for Fluoroquinolone Antibiotics

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The labeling changes are based on a review of postmarketing adverse event reports found in the FDA Adverse Event Reporting System (FAERS) database and published medical literature.

Potential Significant Toxicity With Methotrexate, Trimethoprim-Sulfamethoxazole Combination

Potential Significant Toxicity With Methotrexate, Trimethoprim-Sulfamethoxazole Combination

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The case involved a 68-year-old female patient with rheumatoid arthritis on methotrexate 10mg weekly who presented to the emergency department with complaints of lethargy and weakness after being prescribed a 2-week course of TS for a bacterial skin infection.

FDA Approves Plazomicin for Complicated Urinary Tract Infections

FDA Approves Plazomicin for Complicated Urinary Tract Infections

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Zemdri carries a Boxed Warning describing reports of nephrotoxicity, ototoxicity, and neuromuscular blockade, as well as fetal harm if administered during pregnancy.

FDA Approves New Treatment for Onchocerciasis

FDA Approves New Treatment for Onchocerciasis

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Moxidectin, a macrocyclic lactone, is an anthelmintic drug that selectively binds to the parasite's glutamate-gated chloride ion channels.

FDA Grant Orphan Drug Status to Brincidofovir for Smallpox

FDA Grant Orphan Drug Status to Brincidofovir for Smallpox

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Brincidofovir is the Company's lead candidate, a nucleotide analog that has antiviral activity against variola virus, which causes smallpox.

Treatment for Prosthetic Joint Infections Gets FDA's QIDP Designation

Treatment for Prosthetic Joint Infections Gets FDA's QIDP Designation

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PJI is a challenging complication of joint arthroplasty with few effective treatment options.

Children Typically Have 14 Simple Infections by Age 3 Years

Children Typically Have 14 Simple Infections by Age 3 Years

Children experience a median of 14 infections during their first three years of life, though there is large variation in incidence.

First Single-Dose Oral Therapy for Bacterial Vaginosis Launched

First Single-Dose Oral Therapy for Bacterial Vaginosis Launched

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In both pivotal trials, a statistically significant greater percentage of treatment patients experienced clinical response vs those treated with placebo at 21 to 30 days following a single dose.

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