To investigate what impact antibiotic treatment duration has on CAP outcomes, researchers from the Warren Alpert Medical School of Brown University conducted a search of various databases for studies comparing the safety and efficacy of treatment regimens lasting ≤6 days (short) and ≥7 days (long).
The fixed-dose combination of bictegravir, emtricitabine, and tenofovir alafenamide might provide a safe and efficacious option for ongoing treatment of HIV-1 infection
The labeling changes are based on a review of postmarketing adverse event reports found in the FDA Adverse Event Reporting System (FAERS) database and published medical literature.
The case involved a 68-year-old female patient with rheumatoid arthritis on methotrexate 10mg weekly who presented to the emergency department with complaints of lethargy and weakness after being prescribed a 2-week course of TS for a bacterial skin infection.
Zemdri carries a Boxed Warning describing reports of nephrotoxicity, ototoxicity, and neuromuscular blockade, as well as fetal harm if administered during pregnancy.
Moxidectin, a macrocyclic lactone, is an anthelmintic drug that selectively binds to the parasite's glutamate-gated chloride ion channels.
Brincidofovir is the Company's lead candidate, a nucleotide analog that has antiviral activity against variola virus, which causes smallpox.
PJI is a challenging complication of joint arthroplasty with few effective treatment options.
Children experience a median of 14 infections during their first three years of life, though there is large variation in incidence.
In both pivotal trials, a statistically significant greater percentage of treatment patients experienced clinical response vs those treated with placebo at 21 to 30 days following a single dose.
The Lancet Respiratory Medicine staged a debate between proponents and opponents of pan-TB regimens to tackle the current suboptimal worldwide management of TB resistance.
Investigators examined the association between infection-related medical encounters and disease-modifying treatments for multiple sclerosis.
While isavuconazole is an important therapeutic option in the management of invasive fungal infections, the epidemiology and microbiology of breakthrough infections on this agent are not well understood.
SCY-078 is an investigational antifungal agent that is a semi-synthetic derivative of the natural product enfumafungin.
The Committee voted unanimously (15-0) that substantial evidence on the safety and efficacy of plazomicin was presented for the treatment of cUTI but voted against its use (4-11) for the treatment of bloodstream infections in patients with limited or no treatment options.
During the cold and flu season, the use and over-dosing of paracetamol is common, and may partially be driven by higher use of over-the-counter combination medications for the treatment of upper respiratory cold/flu symptoms.
Review highlights available treatment options and their limitations and provides direction for investigation of future novel combination therapies to further aid in the treatment of Enterococcus faecalis infective endocarditis.
Patients with herpes simplex virus infections may have a 2.56-fold increased risk for developing dementia, and using antiherpetic medications may decrease dementia risk.
Women in the United States with uncomplicated malaria during the first trimester of pregnancy should be treated with the currently recommended options of either mefloquine or quinine plus clindamycin. However, when neither of these options is available, artemether-lumefantrine should be considered for treatment.
Results strongly support the avoidance of colistin-carbapenem combination therapy for carbapenem-resistant A baumannii infections regardless of the infection source.
Results showed that trimethoprim was associated with greater risk for acute kidney injury and hyperkalemia compared with other antibiotic drugs for UTI in older adults.
Subgroup analyses of 2 MODIFY trial data confirmed prior C difficile infection (CDI), age ≥65 years, infection with 027/078/244 strain, compromised immunity, and severe CDI are risk factors for recurrent CDI.
HIV-positive patients with pulmonary tuberculosis benefited from daily antituberculosis therapy in terms of effectiveness and rifampicin resistance.
The findings of this study indicated that rifampicin therapy significantly increased the risk of overall failure and relapse compared with streptomycin.
New study finds an increase in acetaminophen use and overdosing during cold and flu season.
Use of prophylactic antimicrobial therapy was not associated with a reduction in mortality or transfer to critical care compared with patients managed with supportive care only.
Expert perspective on management and treatment of acute urinary tract infections in postmenopausal women.
Treatment of cryptococcal meningitis with two weeks of flucytosine and fluconazole was noninferior to two weeks of amphotericin B. Addition of flucytosine to amphotericin B was superior to amphotericin B plus fluconazole.
Low-dose azithromycin did not meet the prespecified noninferiority margin compared with standard-dose azithromycin in achieving clinical and serological cure in PCR-confirmed active yaws.
Use of oseltamivir does not appear to increase the risk of suicide in pediatric patients.
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Infectious Disease Advisor Articles
- Clinicians Warn That Zika Virus May Still Be an Area of Concern for Travelers
- Inappropriate Prescribing of Antibiotics High in Urgent Care Centers
- Fixed-Dose Bictegravir Regimen: A Safe Alternative in Adults With HIV-1
- Point-Counterpoint: Should We Implement Needle Exchange Programs for the Prevention of Hepatitis C Virus?
- FDA: Vibrio parahaemolyticus Illnesses Tied to Fresh Crab Meat From Venezuela
- Universal Purchase Programs in the United States May Not Effectively Increase Vaccination Rates
- Tick-Caused Meat Allergy on the Rise in the United States
- Prognostic Biomarkers to Guide Antibiotic Therapy in Critically Ill Patients
- Sofosbuvir/Velpatavir Effective for HCV-Infected Liver Transplant Recipients
- Should Metronidazole Be Recommended for Mild Clostridium difficile Infections?
- Same-Day ART Initiation in HIV+ Pregnant Women Does Not Worsen Outcomes
- Novel Nanodiagnostic Panel May Reduce Empiric Antifungal Use in High-Risk Candidemia
- Antimicrobial Lock Solutions Are Cost-Effective for Preventing Central Line-Associated Bloodstream Infections
- Predictors of Influenza Vaccine Acceptance in Inflammatory Rheumatic Diseases
- Pegylated Interferon, Ribavirin May Improve LV Diastolic Dysfunction in Chronic Hepatitis C