Further studies are warranted to assess the efficacy and safety of fosfomycin plus imipenem against methicillin-resistant Staphylococcus aureus complicated infections.
After hospital discharge for sepsis, the healthcare team should focus on identifying new functional, mental, and cognitive impairments and referring patients to appropriate treatment; reviewing and adjusting long-term medications; and evaluating for treatable conditions that commonly result in hospitalizations.
Eggerthella lenta displays high minimal inhibitory concentrations to piperacillin-tazobactam (TZP), and empiric TZP monotherapy is a risk factor for 30-day mortality.
Meropenem-vaborbactam noninferior to piperacillin-tazobactam for complicated urinary tract infections: The TANGO I trialMarch 02, 2018
In this randomized controlled trial, meropenem-vaborbactam was found to be non-inferior to piperacillin-tazobactam for treating complicated urinary tract infections.
Further studies are required to evaluate the effectiveness of the ivermectin schedule for treatment of strongyloidiasis, and quantitative methods of high sensitivity and accuracy are needed to monitor treatment success or to predict reactivation.
The FDA has accepted and granted priority review for TPOXX, an antiviral therapy for smallpox.
As first-line treatment for human African trypanosomiasis requires administration in a hospital by trained personal, a short-course oral option presents significant advantages for managing patients with this tropical disease.
In this combined phase 1-2a study, mogamulizumab used for treatment of human T-lymphotropic virus type 1 associated myelopathy was safe and associated with improvement in biomarkers of disease, as well as improvements in spasticity and motor disability.
For pregnant women in their first trimester, a 2011 Committee Opinion from the ACOG recommended that sulfonamides and nitrofurantoin may be prescribed only if other antimicrobial therapies are deemed clinically inappropriate.
New research may explain why many patients report lingering symptoms after receiving antibiotic therapy for the treatment of Lyme disease.
Five factors were found to be significantly associated with UTI antibiotic use in order of decreasing association: presence of urinary catheter, urinary frequency, fever, new-onset hypotension, and confusion.
Researchers conducted a systematic review and meta-analysis to assess the effectiveness and safety of short-term vs prolonged infusion of antipseudomonal β-lactams in patients with sepsis.
The hepatitis C treatment, sofosbuvir was found to be effective against Zika virus in a preclinical trial.
Vancomycin is the first liquid oral treatment for C diff-associated diarrhea.
Recent significantly increased influenza activity prompts CDC advisory for antiviral treatment.
Results support a role for ceftazidime-avibactam as a potential alternative to carbapenems in patients with nosocomial pneumonia (including ventilator-associated pneumonia) caused by Gram-negative pathogens.
Shorter duration of glecaprevir-pibrentasvir effective against hepatitis C virus: The ENDURANCE trialsJanuary 25, 2018
Both 8 and 12-week regimens of glecaprevir-pibrentasvir were highly efficacious in producing sustained virologic response in patients infected with hepatitis C virus genotypes 1 and 3, and the 8-week treatment duration was noninferior to 12-week duration.
The EXTEND study addresses sustained cure as a primary measure of treatment success in a high-risk patient population, with recurrence monitored up to day 90.
Children with tuberculosis who received 3 months of directly observed preventative therapy were >25 times more likely to complete their treatment regimen than those who received 9 months of self-administered therapy.
Iclaprim was noninferior to vancomycin with respect to the early clinical response at an early time point in the treatment of ABSSSI caused or suspected to be caused by gram-positive organisms.
Dr McKinnell provides a summary of drugs in development for infections caused by Gram-negative bacteria, including carbapenem-resistant Pseudomonas aeruginosa and carbapenem-resistant Enterobacteriaceae.
Although most patients would choose surgical intervention for treatment of acute uncomplicated appendicitis, some would opt for antibiotics alone.
Clofazimine was safe and well-tolerated as part of a multidrug regimen for the treatment of children with Mycobacterium abscessus odontogenic infections.
Reduced DAA delays and denials for patients with HCV reduced with provider-pharmacy collaboration.
The FDA accepted a new drug application for plazomicin for complicated urinary tract infections.
Deintensification of treatment from chemoradiotherapy to one modality may compromise safety in patients with human papillomavirus (HPV)+ stage 1 or 2 oropharyngeal cancer.
Developing alternative, non-antibiotic treatments for certain "self-limiting infections" may help preserve the effectiveness of antibiotics.
A new immunotherapy approach has shown promise in it's first-in-human trial for antibiotic-resistant bacteria.
Letermovir prophylaxis significantly decreased the incidence of cytomegalovirus infection through 24 weeks following hematopoietic stem cell transplantation. Letermovir was associated with a significantly lower all-cause mortality compared to placebo and did not demonstrate any serious toxicities.
The benefit of antibiotic treatment needs to be weighed against the potential for adverse effects, at both the individual level (adverse drug reactions) and the population level (as a driver of antibiotic resistance).
Sign Up for Free e-newsletters
Infectious Disease Advisor Articles
- Major Advances on Horizon for Tick-Borne Disease Testing
- Measles Vaccination After Third Dose of DTP Vaccine May Improve Child Survival
- Vegetation Size May Increase Mortality Risk in Infective Endocarditis
- FDA Approves Blood Screens for Tickborne Parasite
- Effect of Vaccine Antigen Exposure in First 23 Months of Life
- Treatment for MRSA Complicated Bacteremia and Infective Endocarditis
- T2Candida May Shorten Time to Candida Detection, Species Identification
- Major Advances on Horizon for Tick-Borne Disease Testing
- Harnessing Mucus to Fight Human Immunodeficiency Virus
- Incidence of Surgical Site Infections Highest in Lower-Income Countries