Control of active tuberculosis (TB) and a major effort to decrease latent TB infection are both necessary to reduce morbidity and achieve TB elimination in the United States.
HIV-positive patients with pulmonary tuberculosis benefited from daily antituberculosis therapy in terms of effectiveness and rifampicin resistance.
Findings from this phase 4 study call for a re-evaluation of the current WHO and CDC guidelines of isoniazid preventive therapy for the prevention of tuberculosis in pregnant women with HIV.
Children receiving 3 months of once-weekly isoniazid and rifapentine were more likely to complete therapy than those receiving 9 months of daily isoniazid.
Benefits of urine lipoarabinomannan include its rapid point-of-care platform, low cost, and readily accessible sample type.
Patients with type 2 diabetes treated with sulfonylureas may be at a higher risk of contracting tuberculosis.
Co-infected participants treated concurrently for multidrug-resistant tuberculosis and HIV had similar survival to participants with multidrug-resistant tuberculosis alone.
Children with tuberculosis who received 3 months of directly observed preventative therapy were >25 times more likely to complete their treatment regimen than those who received 9 months of self-administered therapy.
Report updated the 2006 American College of Chest Physicians clinical practice guideline for cough due to TB and other chronic infections.
A representative from the California Department of Public Health discusses latent TB infection testing and treatment recommendations and reasons why US physicians have been slow to test for and treat for the condition.
The iAdhere study found that once-weekly self-administration of isoniazid and rifapentine had high treatment completion rates in the United States, Hong Kong, Spain, and South Africa.
An automated molecular assay can detect Mycobacterium tuberculosis with resistance to drugs directly from sputum specimens.
Additional strategies to prevent transmission will be necessary to stop multidrug-resistant (MDR) or extensively drug-resistant tuberculosis in countries with a high burden of MDR tuberculosis.
Diagnosis of tuberculous meningitis is challenging, although new, next-generation rapid POC testing holds promise for greatly improved sensitivity. Shorter and more effective treatments are needed.
Isoniazid-rifapentine regimen sees high completion rates for latent tuberculosis infection.
Three months of rifapentine + isoniazid using directly observed therapy resulted in a higher completion rate and no loss of follow-up for latent tuberculosis.
Researchers assess all-cause mortality during tuberculosis treatment in patients with diabetes, the use of metformin, and effect sputum culture-conversion rates.
Qiagen announced on October 5, 2017, the marketing of an improved blood test for tuberculosis infection.
The relationship between negative tuberculin skin test and in-hospital mortality has not been previously studied.
This new risk score may guide the identification of high-risk people who would benefit from preventative measures.
A new study examined whether isoniazid resistance was associated with variations in treatment outcomes in patients receiving standard first-line pharmacotherapy for TB.
A change of QuantiFERON-TB interferon (IFN)γ values could improve tuberculosis detection.
Mycobacterium tuberculosis engages the host immune response to drive immunopathology and tissue destruction by disrupting negative regulatory pathways in human macrophages.
A recent update of a meta-analysis evaluating treatments for latent tuberculosis infection found that several regimens, including those with a low pill burden and short duration, were safe and effective.
A decrease in all-cause mortality associated with multidrug-resistant tuberculosis (TB) can be correlated with an increase in directly observed therapy.
The vaccine bacillus Calmette-Guérin for tuberculosis may have the potential to reverse type 1 diabetes.
Deep learning with deep convolutional neural networks can accurately detect tuberculosis on chest radiographs.
Patients with a history of tuberculosis are at risk for developing osteoporosis or osteoporotic fractures.
Interrupting the transmission of extensively drug-resistant tuberculosis is the most important factor in curtailing the epidemic areas of high disease burden.
Immediate antiretroviral therapy lowers the risk for severe bacterial infections in patients with HIV and high CD4. This effect may be mediated by increases in CD4 count, but not by increases in neutrophil count.
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Infectious Disease Advisor Articles
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- Fluoroquinolone Use May Increase Risk for Aortic Aneurysm and Dissection
- Fingerstick Point-of-Care Test Allows for Single-Visit HCV Diagnoses
- Clostridium difficile Infection in the Intensive Care Setting
- Combating Medically Important Antibiotic Use in Food-Producing Animals
- Religious Exemptions vs Mandatory Vaccinations: An Expert Perspective
- 2018 Vaccination Schedule: Adults
- Possible Inhibitory Effect of HCV-Induced Steatogenesis by HBV
- Delayed Management of Severe Sepsis, Septic Shock Increases Mortality
- MenB Vaccine Gets Breakthrough Therapy Designation for Children Ages 1-9 Years
- CDC: Recommendations on the Use of Heplisav-B Published
- Non-Targeted HIV Testing in ED Acceptable to Patients