Tuberculosis

Update to Pulmonary Tuberculosis Screening Recommendations

Update to Pulmonary Tuberculosis Screening Recommendations

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Report updated the 2006 American College of Chest Physicians clinical practice guideline for cough due to TB and other chronic infections.

Update on Latent Tuberculosis Testing and Treatment

Update on Latent Tuberculosis Testing and Treatment

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A representative from the California Department of Public Health discusses latent TB infection testing and treatment recommendations and reasons why US physicians have been slow to test for and treat for the condition.

Likelihood of Self-Administered Treatment Completion for Latent TB

Likelihood of Self-Administered Treatment Completion for Latent TB

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The iAdhere study found that once-weekly self-administration of isoniazid and rifapentine had high treatment completion rates in the United States, Hong Kong, Spain, and South Africa.

Automated Molecular Assay Detects Drug-Resistant Tuberculosis

Automated Molecular Assay Detects Drug-Resistant Tuberculosis

An automated molecular assay can detect Mycobacterium tuberculosis with resistance to drugs directly from sputum specimens.

Drug-Resistant Tuberculosis to Increase in 4 High-Burden Countries

Drug-Resistant Tuberculosis to Increase in 4 High-Burden Countries

Additional strategies to prevent transmission will be necessary to stop multidrug-resistant (MDR) or extensively drug-resistant tuberculosis in countries with a high burden of MDR tuberculosis.

Challenges in Diagnosing Tuberculous Meningitis

Challenges in Diagnosing Tuberculous Meningitis

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Diagnosis of tuberculous meningitis is challenging, although new, next-generation rapid POC testing holds promise for greatly improved sensitivity. Shorter and more effective treatments are needed.

Isoniazid-Rifapentine for Latent TB Sees High Completion Rates

Isoniazid-Rifapentine for Latent TB Sees High Completion Rates

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Isoniazid-rifapentine regimen sees high completion rates for latent tuberculosis infection.

Latent Tuberculosis May Benefit From 3-Month Rifapentine, Isoniazid Tx

Latent Tuberculosis May Benefit From 3-Month Rifapentine, Isoniazid Tx

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Three months of rifapentine + isoniazid using directly observed therapy resulted in a higher completion rate and no loss of follow-up for latent tuberculosis.

Metformin Reduces Mortality During Tuberculosis Therapy

Metformin Reduces Mortality During Tuberculosis Therapy

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Researchers assess all-cause mortality during tuberculosis treatment in patients with diabetes, the use of metformin, and effect sputum culture-conversion rates.

Tuberculosis Diagnosis: Improved Blood Test by Qiagen to Hit Shelves

Tuberculosis Diagnosis: Improved Blood Test by Qiagen to Hit Shelves

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Qiagen announced on October 5, 2017, the marketing of an improved blood test for tuberculosis infection.

Accuracy of Negative Tuberculin Skin Test in Predicting In-Hospital Tuberculosis  Mortality

Accuracy of Negative Tuberculin Skin Test in Predicting In-Hospital Tuberculosis Mortality

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The relationship between negative tuberculin skin test and in-hospital mortality has not been previously studied.

Risk for TB Infection Predicted by New Scoring System

Risk for TB Infection Predicted by New Scoring System

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This new risk score may guide the identification of high-risk people who would benefit from preventative measures.

Time to Sputum Culture Conversion Similar in Isoniazid-Resistant and Susceptible TB

Time to Sputum Culture Conversion Similar in Isoniazid-Resistant and Susceptible TB

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A new study examined whether isoniazid resistance was associated with variations in treatment outcomes in patients receiving standard first-line pharmacotherapy for TB.

Tuberculosis Detection Could Improve With Conversion Value Change

Tuberculosis Detection Could Improve With Conversion Value Change

A change of QuantiFERON-TB interferon (IFN)γ values could improve tuberculosis detection.

<i>M tuberculosis</i> Disrupts Regulatory Macrophage Pathways Driving Immunopathology

M tuberculosis Disrupts Regulatory Macrophage Pathways Driving Immunopathology

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Mycobacterium tuberculosis engages the host immune response to drive immunopathology and tissue destruction by disrupting negative regulatory pathways in human macrophages.

Update on Safe, Effective Treatments for Latent Tuberculosis Infection

Update on Safe, Effective Treatments for Latent Tuberculosis Infection

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A recent update of a meta-analysis evaluating treatments for latent tuberculosis infection found that several regimens, including those with a low pill burden and short duration, were safe and effective.

Mortality in MDR TB Decreases With Directly Observed Therapy

Mortality in MDR TB Decreases With Directly Observed Therapy

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A decrease in all-cause mortality associated with multidrug-resistant tuberculosis (TB) can be correlated with an increase in directly observed therapy.

Tuberculosis Vaccine May Reverse Type 1 Diabetes

Tuberculosis Vaccine May Reverse Type 1 Diabetes

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The vaccine bacillus Calmette-Guérin for tuberculosis may have the potential to reverse type 1 diabetes.

Detecting TB With Deep Convolutional Neural Networks

Detecting TB With Deep Convolutional Neural Networks

Deep learning with deep convolutional neural networks can accurately detect tuberculosis on chest radiographs.

Tuberculosis Increases Risk of Osteoporosis, Osteoporotic Fractures

Tuberculosis Increases Risk of Osteoporosis, Osteoporotic Fractures

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Patients with a history of tuberculosis are at risk for developing osteoporosis or osteoporotic fractures.

Interrupting Transmission of Tuberculosis Key to Containing Global Epidemic

Interrupting Transmission of Tuberculosis Key to Containing Global Epidemic

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Interrupting the transmission of extensively drug-resistant tuberculosis is the most important factor in curtailing the epidemic areas of high disease burden.

Early ART Reduces Bacterial Infection Risk in HIV With High CD4 Counts

Early ART Reduces Bacterial Infection Risk in HIV With High CD4 Counts

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Immediate antiretroviral therapy lowers the risk for severe bacterial infections in patients with HIV and high CD4. This effect may be mediated by increases in CD4 count, but not by increases in neutrophil count.

Poor Outcomes Seen With First-Line Treatment of Isoniazid-Resistant TB

Poor Outcomes Seen With First-Line Treatment of Isoniazid-Resistant TB

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Literature review and meta-analysis reveal poor treatment outcomes in patients with isoniazid-resistant TB.

Fourth-Generation Fluroquinolones Effective Despite Pyrazinamide-Rifampicin Linked TB Resistance

Fourth-Generation Fluroquinolones Effective Despite Pyrazinamide-Rifampicin Linked TB Resistance

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Pyrazinamide resistance linked with rifampicin resistance in treating TB, however, fourth generation fluoroquinolones are still highly effective.

US Preventive Services Task Force Makes Recommendation for TB Screening

US Preventive Services Task Force Makes Recommendation for TB Screening

The statement defines some of those people who may be at risk for latent tuberculosis infection (LTBI), including people who have lived in group settings where TB exposure is likely, or those people who resided or were born in countries with a high prevalence of TB.

Researchers Examine HIV, TB Interaction

Researchers Examine HIV, TB Interaction

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More study on the interaction between HIV and TB is needed because there is a lot that is unknown.

Leveling of Tuberculosis Reported in United States

Leveling of Tuberculosis Reported in United States

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Two reports released this week call for increased investments to speed development of diagnostic tests, drugs and vaccines, and to improve medication delivery.

Large Number of Mutations Needed to Identify TB Drug Resistance

Large Number of Mutations Needed to Identify TB Drug Resistance

Predicted resistance to rifampicin and isoniazid ID'd based on 238 mutations across 18 genetic loci.

Unexpected Decline in Tuberculosis Among Foreign-Born in the United States

Unexpected Decline in Tuberculosis Among Foreign-Born in the United States

Decline in tuberculosis cases in both recent and non-recent entrants to the United States.

Tuberculosis Test May Underreport in Pregnant Women With HIV

Tuberculosis Test May Underreport in Pregnant Women With HIV

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Of the 252 women who were enrolled, 28% had a positive interferon gamma release assay (IGRA) but only 10% had a positive TST (P<.005).

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