Tuberculosis

Statins May Decrease the Risk for Active Tuberculosis

Statins May Decrease the Risk for Active Tuberculosis

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The use of statins may decrease the risk for active tuberculosis.

New Assay Efficacious for Diagnosing Extrapulmonary Tuberculosis and Rifampin Resistance

New Assay Efficacious for Diagnosing Extrapulmonary Tuberculosis and Rifampin Resistance

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Xpert MTB/RIF may be helpful for confirming a diagnosis of extrapulmonary tuberculosis and can accurately detect resistance to rifampicin.

Patient Develops Rare Extrapulmonary Manifestation of Tuberculosis

Patient Develops Rare Extrapulmonary Manifestation of Tuberculosis

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The patient, a 42-year-old female with systemic lupus erythematosus treated with mycophenolate mofetil and prednisone, reported swelling and pain in the fifth finger of her left hand for about 1-week.

Minimum Inhibitory Concentrations May Predict Risk of Relapse in Tuberculosis

Minimum Inhibitory Concentrations May Predict Risk of Relapse in Tuberculosis

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Higher minimum inhibitory concentration values of isoniazid or rifampin are associated with a greater risk of relapse in drug-susceptible tuberculosis than lower MICs.

HIV, TB Co-Infection Associated With Decreased Neurological Performance

HIV, TB Co-Infection Associated With Decreased Neurological Performance

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Co-infection of HIV+ and tuberculosis (TB) may be associated with decreased neurological and neuropsychological functioning.

Tuberculosis Assessment More Efficient With Sputum Molecular Testing

Tuberculosis Assessment More Efficient With Sputum Molecular Testing

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In patients with possible tuberculosis, sputum molecular testing may facilitate a more accurate and efficient assessment of disease.

Relapse-Free Cure From MDR-TB Higher Than Anticipated

Relapse-Free Cure From MDR-TB Higher Than Anticipated

The frequency of relapse-free cure from multidrug-resistant tuberculosis is higher than previously anticipated.

Minimum Inhibitory Concentration of Isoniazid, Rifampin May Predict TB Relapse

Minimum Inhibitory Concentration of Isoniazid, Rifampin May Predict TB Relapse

Higher MIC in pretreatment M. tuberculosis isolates linked to relapse risk.

Similar Safety and Efficacy for Rifampin vs Isoniazid in Children, Adolescents

Similar Safety and Efficacy for Rifampin vs Isoniazid in Children, Adolescents

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For children younger than 18 years, 4 months of rifampin to treat latent Mycobacterium tuberculosis had similar rates of safety and efficacy and higher rates of adherence compared with 9 months of isoniazid.

Rifampin Non-Inferior to Isoniazid for Preventing Active Tuberculosis

Rifampin Non-Inferior to Isoniazid for Preventing Active Tuberculosis

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A 4-month regimen of rifampin was not inferior to 9 months of treatment with isoniazid in preventing active tuberculosis.

A Pan-Tuberculosis Regimen: The Debate Continues

A Pan-Tuberculosis Regimen: The Debate Continues

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Last month the South Africa National Tuberculosis Program decided to make oral bedaqualine available for all rifampin-resistant TB (RR-TB) in place of — the often more toxic — injectable drugs.

CDC Updates Recommendations for Once-Weekly Isoniazid-Rifapentine for Latent TB Infection

CDC Updates Recommendations for Once-Weekly Isoniazid-Rifapentine for Latent TB Infection

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The CDC has updated its recommendation for once-weekly isoniazid-rifapentine for 12 weeks for the treatment of latent tuberculosis infection.

CDC: Updated Recommendations for Latent TB Infection Treatment

CDC: Updated Recommendations for Latent TB Infection Treatment

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The CDC has issued updated recommendations regarding the use of 3HP for the treatment of latent tuberculosis.

Could a New Universal Tuberculosis Regimen Help End the TB Pandemic?

Could a New Universal Tuberculosis Regimen Help End the TB Pandemic?

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The Lancet Respiratory Medicine staged a debate between proponents and opponents of pan-TB regimens to tackle the current suboptimal worldwide management of TB resistance.

Simple Blood-Based PCR Test Can Predict Progression to Tuberculosis

Simple Blood-Based PCR Test Can Predict Progression to Tuberculosis

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Study identifies and validates a simple PCR-based test from accessible blood samples that predicts TB in heterogeneous African populations with intermediate to high TB burdens.

Infections Complicating the Use of Monoclonal Antibodies for Malignancy

Infections Complicating the Use of Monoclonal Antibodies for Malignancy

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In this review, David C. Helfgott, MD, editorial advisory board member for Infectious Disease Advisor, focuses on infectious complications from the use of monoclonal antibodies for malignancy.

Cavity Volume and Proximity to Airway May Affect Tuberculosis Treatment

Cavity Volume and Proximity to Airway May Affect Tuberculosis Treatment

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Large cavitary lung disease may increase cough frequency that lasts for a longer duration in individuals with tuberculosis.

CDC: Declining Incidence of TB in the United States Remains Inadequate for Elimination

CDC: Declining Incidence of TB in the United States Remains Inadequate for Elimination

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Control of active tuberculosis (TB) and a major effort to decrease latent TB infection are both necessary to reduce morbidity and achieve TB elimination in the United States.

Effectiveness of Daily vs Thrice-Weekly Tuberculosis Regimens in HIV Patients

Effectiveness of Daily vs Thrice-Weekly Tuberculosis Regimens in HIV Patients

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HIV-positive patients with pulmonary tuberculosis benefited from daily antituberculosis therapy in terms of effectiveness and rifampicin resistance.

Adverse Pregnancy Outcomes With Isoniazid Preventive Therapy in HIV

Adverse Pregnancy Outcomes With Isoniazid Preventive Therapy in HIV

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Findings from this phase 4 study call for a re-evaluation of the current WHO and CDC guidelines of isoniazid preventive therapy for the prevention of tuberculosis in pregnant women with HIV.

Shorter Tuberculosis Regimens Associated With Greater Treatment Adherence

Shorter Tuberculosis Regimens Associated With Greater Treatment Adherence

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Children receiving 3 months of once-weekly isoniazid and rifapentine were more likely to complete therapy than those receiving 9 months of daily isoniazid.

Mortality in HIV-Infected Children Predicted by Urine TB Lipoarabinomannan

Mortality in HIV-Infected Children Predicted by Urine TB Lipoarabinomannan

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Benefits of urine lipoarabinomannan include its rapid point-of-care platform, low cost, and readily accessible sample type.

Decreased Tuberculosis Risk With Metformin vs Sulfonylureas

Decreased Tuberculosis Risk With Metformin vs Sulfonylureas

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Patients with type 2 diabetes treated with sulfonylureas may be at a higher risk of contracting tuberculosis.

Survival Outcomes Improved With Concurrent Treatment for Multidrug-Resistant TB and HIV

Survival Outcomes Improved With Concurrent Treatment for Multidrug-Resistant TB and HIV

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Co-infected participants treated concurrently for multidrug-resistant tuberculosis and HIV had similar survival to participants with multidrug-resistant tuberculosis alone.

Shorter pediatric tuberculosis treatment linked to higher completion rates

Children with tuberculosis who received 3 months of directly observed preventative therapy were >25 times more likely to complete their treatment regimen than those who received 9 months of self-administered therapy.

Update to Pulmonary Tuberculosis Screening Recommendations

Update to Pulmonary Tuberculosis Screening Recommendations

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Report updated the 2006 American College of Chest Physicians clinical practice guideline for cough due to TB and other chronic infections.

Update on Latent Tuberculosis Testing and Treatment

Update on Latent Tuberculosis Testing and Treatment

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A representative from the California Department of Public Health discusses latent TB infection testing and treatment recommendations and reasons why US physicians have been slow to test for and treat for the condition.

Likelihood of Self-Administered Treatment Completion for Latent TB

Likelihood of Self-Administered Treatment Completion for Latent TB

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The iAdhere study found that once-weekly self-administration of isoniazid and rifapentine had high treatment completion rates in the United States, Hong Kong, Spain, and South Africa.

Automated Molecular Assay Detects Drug-Resistant Tuberculosis

Automated Molecular Assay Detects Drug-Resistant Tuberculosis

An automated molecular assay can detect Mycobacterium tuberculosis with resistance to drugs directly from sputum specimens.

Drug-Resistant Tuberculosis to Increase in 4 High-Burden Countries

Drug-Resistant Tuberculosis to Increase in 4 High-Burden Countries

Additional strategies to prevent transmission will be necessary to stop multidrug-resistant (MDR) or extensively drug-resistant tuberculosis in countries with a high burden of MDR tuberculosis.

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