Vaccines

Tetravalent <i>E coli</i> Vaccine Safe, Immunogenic in Women With Recurrent UTI

Tetravalent E coli Vaccine Safe, Immunogenic in Women With Recurrent UTI

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Phase 1b trial finds tetravalent E coli bioconjugate vaccine candidate in women with recurrent UTI safe and immunogenic.

Review of <i>Clostridium difficile</i> Vaccines in Development

Review of Clostridium difficile Vaccines in Development

Drs Kociolek and Shulman, from the division of infectious diseases at the Ann & Robert H. Lurie Children's Hospital of Chicago in Illinois, review all the current vaccine candidates in development for Clostridium difficile infection.

Influenza Vaccine Safe During Any Trimester of Pregnancy

Influenza Vaccine Safe During Any Trimester of Pregnancy

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Researchers found that the influenza vaccine, when given to pregnant women, does not affect weeks' gestation of the infant at birth or the infant's birth weight.

Plague Vaccine Granted Orphan Drug Designation

Plague Vaccine Granted Orphan Drug Designation

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FDA has granted Orphan Drug designation to the recombinant rF1V plague vaccine for pre-exposure prophylaxis of Yersinia pestis infection, also known as, the plague.

Immunity Persists for Ebola Vaccines at One Year

Immunity Persists for Ebola Vaccines at One Year

A strategy of preemptive use of an AD26.ZEBOV followed by MVA-BN-Filo immunization schedule in at-risk populations may offer advantages over reactive use of single-dose vaccine regimens.

Reducing CVD Risk Using a Vaccine-Based Approach

Reducing CVD Risk Using a Vaccine-Based Approach

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In preclinical animal studies, vaccination against PSCK9 lowered serum lipids and vaccination against ApoC3 lowered serum triglyceride levels.

Decrease in Pneumococcal Bacteremia With Routine PCV13 Vaccine

Decrease in Pneumococcal Bacteremia With Routine PCV13 Vaccine

Researchers observed a 95.3% reduction of S pneumoniae bacteremia after implementation of routine immunization with the pneumococcal conjugate vaccine.

NIH: Respiratory Syncytial Virus Vaccine Testing Begins

NIH: Respiratory Syncytial Virus Vaccine Testing Begins

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At this time, no vaccine to prevent or drug to treat respiratory syncytial virus infection is available.

Investigational Malaria Vaccine Shows Durable Response to Multiple Strains

Investigational Malaria Vaccine Shows Durable Response to Multiple Strains

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3 IV doses of PfSPZ vaccine conferred protection after immunization against different Pf strains of malaria than the one the vaccine came from.

NIH Begins Study on a Universal Mosquito-Borne Diseases Vaccine

NIH Begins Study on a Universal Mosquito-Borne Diseases Vaccine

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Investigational vaccine is designed to trigger an immune response to mosquito saliva rather than to a specific virus or parasite carried by mosquitoes.

VZV Vaccine Promising in Immunocompromised Patients With Herpes Zoster

VZV Vaccine Promising in Immunocompromised Patients With Herpes Zoster

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Phase 3 study looked at the safety, tolerability, efficacy, and immunogenicity of inactivated VZV Vaccine in recipients of auto-HSCT.

Human Papillomavirus Vaccine Not Linked to Autoimmune Disease

Human Papillomavirus Vaccine Not Linked to Autoimmune Disease

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HPV vaccines do not increase the risk for autoimmune diseases and may have a protective effect against central demyelination, multiple sclerosis, and autoimmune thyroiditis.

Intramuscular Flu Vaccination Recommended for Patients With Eczema

Intramuscular Flu Vaccination Recommended for Patients With Eczema

Patients with atopic dermatitis with S aureus had reduced immune response to intradermal influenza vaccination but not intramuscular vaccination.

High-Dose Influenza Vaccine in H3N2 Season More Effective in Seniors

High-Dose Influenza Vaccine in H3N2 Season More Effective in Seniors

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Compared to infections by H1N1 or influenza B viruses, H3N2 influenza viruses have been associated with higher mortality in older adults.

Novel mRNA Zika Virus Vaccine Shows Rapid and Durable Protection

Novel mRNA Zika Virus Vaccine Shows Rapid and Durable Protection

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A new vaccine candidate uses an mRNA platform to deliver safe, low doses of a vaccine that offers high levels of sustained protection against Zika virus.

Quadrivalent Influenza Vaccine Found to be Safe

Quadrivalent Influenza Vaccine Found to be Safe

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No safety signals associated with the administration of quadrivalent live attenuated influenza vaccine were observed, according to a large population study.

Efficacy of 23-Valent Pneumococcal Vaccine in Rheumatoid Arthritis Questioned

Efficacy of 23-Valent Pneumococcal Vaccine in Rheumatoid Arthritis Questioned

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A prospective, multicenter, randomized, placebo-controlled trial evaluates efficacy of the 23-valent pneumococcal polysaccharide vaccine in preventing pneumonia in patients with rheumatoid arthritis.

CDC Reports on Seasonal Influenza Vaccine Effectiveness

CDC Reports on Seasonal Influenza Vaccine Effectiveness

For the predominant circulating influenza A type H3N2 flu strain, the vaccine effectiveness comes in at 43%.

Respiratory Vaccination Reduces Heart Failure Outcomes

Respiratory Vaccination Reduces Heart Failure Outcomes

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Vaccination may be able to prevent significant morbidity and mortality associated with heart failure, according to a study.

ACIP Issues 2017 Updated Immunization Schedule

ACIP Issues 2017 Updated Immunization Schedule

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The Advisory Committee on Immunization Practices has issued updated 2017 immunization schedules for for children, adolescents, and adults.

Early Study Shows Great Potential for Genital Herpes Vaccine

Early Study Shows Great Potential for Genital Herpes Vaccine

The new trivalent vaccine targets 3 different parts of the virus, shutting down its ability to enter cells and to evade detection by the immune system.

AAP: Better Strategies Needed to Increase Adolescent Vaccination Rates

AAP: Better Strategies Needed to Increase Adolescent Vaccination Rates

According to the American Academy of Pediatrics, HPV and influenza immunization rates remain well below the Healthy People 2020 goals.

Quadracel Vaccine Now Available in the US

Quadracel Vaccine Now Available in the US

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Quadracel was approved for active immunization against diphtheria, tetanus, pertussis and poliomyelitis in children aged 4 to 6 years old.

Efficacy of Pneumococcal Vaccines for Preventing Pneumonia in COPD

Efficacy of Pneumococcal Vaccines for Preventing Pneumonia in COPD

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A Cochrane review found that polyvalent pneumococcal vaccines offered significant protection against CAP in patients with COPD but did not lower the risk of confirmed pneumococcal pneumonia.

Double-Dose Influenza Vaccine Safe, Effective in Young Children

Double-Dose Influenza Vaccine Safe, Effective in Young Children

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Doubling the standard dose of the inactivated quadrivalent influenza vaccine in children younger than 3 years old had similar efficacy and safety to the standard dose of the vaccine licensed in the United States.

Prevalence of Genital HPV in US High Among Men

Prevalence of Genital HPV in US High Among Men

Overall genital HPV infection prevalence widespread among all age groups of men, and the HPV vaccination coverage is low.

LAIV Safe in Children With Underlying Medical Conditions

LAIV Safe in Children With Underlying Medical Conditions

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A CDC study found no significant differences in risks of hospitalization following vaccination with LAIV in children who had underlying illnesses compared to healthy children.

Study Finds Single-Dose <i>S aureus</i> Vaccine Effective and Durable

Study Finds Single-Dose S aureus Vaccine Effective and Durable

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A 4-antigen vaccine for Staphylococcus aureus disease demonstrates robust functional immune responses durable through month 12.

How Effective is the Meningococcal Conjugate Vaccine Over Time?

How Effective is the Meningococcal Conjugate Vaccine Over Time?

Vaccine efficiency began decreasing as soon as 1-year post-vaccination.

Influenza Activity Picks Up Pace Across US

Influenza Activity Picks Up Pace Across US

The most common strain is H3N2, which is contained in the 2016-2017 influenza vaccine.

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