A novel service to target appropriate antimicrobial prescription and improve antibiotic stewardship shows potential according.
Adding glycopeptide to the spacer in 2-stage exchange procedures for periprosthetic joint infections reduces positive cultures during re-implantation.
Oral vancomycin is effective in preventing C difficile infection in allogeneic hematopoietic cell transplant patients and does not raise the risk for GVHD.
Resistance of gram negative bacteria to some cephalosporins has emerged as a significant threat over the last few decades as a results of ESBL enzymes.
The inappropriate use of antibiotics as prophylaxis and treatment in acute pancreatitis is common, highlighting the efforts required for antibiotic stewardship.
In acute ischemic or hemorrhagic stroke, prophylactic antibiotics reduce the overall infection rate, but do not reduce the risk for pneumonia, death, or dependency.
These findings may highlight physician difficulty explaining to patients why antibiotics are not required.
Single doses of ceftolozane and tazobactam were well tolerated in children with gram-negative bacterial infections and no safety concerns were identified.
The study included 530 patients, aged 18 to 60 years, with computed tomography-confirmed uncomplicated acute appendicitis.
Many antibiotic adverse drug events led to emergency department visits, particularly among young children, highlighting a need for better communication regarding the risks of overprescribing.
As infections from drug-resistant microbes continue to rise, the development of new antibiotics has declined since the golden age of antibiotic discovery in the mid-20th century.
Neil Clancy, MD, from the VA Pittsburgh Health Care System, shares highlights from ASM Microbe 2018.
Alternative antibiotics with a lower ecological impact were suggested for 55.2% of relevant ceftriaxone prescriptions in a university hospital emergency department setting during 2016.
A study recently published in the Journal of Antimicrobial Chemotherapy shows the clinical benefits of early target attainment of azithromycin therapy when treating children with lower respiratory tract infections.
Pivmecillinam treatment for community-acquired urinary tract infections (UTIs) caused by ESBL-producing Escherichia coli is a reasonable option.
A systematic literature review, published in Clinical Infectious Diseases, found no evidence supporting a benefit to antibacterial therapy for osteomyelitis in patients with stage IV sacral pressure ulcers.
There is a correlation for documented penicillin allergy with increased risk of MRSA and C diff, which is mediated by increased use of β-lactam alternative antibiotics.
A 48-hour automatic stop order for antibiotics embedded within a NICU admission order set effectively reduced antibiotic use.
Between 1999 and 2012, Acinetobacter baumannii antibiotic resistance increased in children.
A review summarizes outpatient prescription practices and identifies factors that may influence physician prescribing behaviors.
Early antibiotic use was examined among very low birth weight infants across hospitals in the United States.
Time to optimal antimicrobial therapy for positive blood cultures was assessed in a pediatric population.
Researchers found no association between starting colistin before final culture results and survival at 14 and 28 days.
While macrolides had no direct effect on lung function, their use significantly improved asthma control and quality of life in patients with asthma.
Researchers examined the association of timing, frequency, and class of antibiotic use during pregnancy on the development of childhood asthma.
Pharmacists are increasingly becoming involved in antibiotic surveillance, including e-surveillance methods; formulation of antibiotic-use policies; and day-to-day control of problematic antibiotic use.
The new WHO guidelines restricts antibiotic use in animals for purposes of growth promotion as well as avoidance of use for disease prevention.
Use of prophylactic antimicrobial therapy was not associated with a reduction in mortality or transfer to critical care compared with patients managed with supportive care only.
Findings from the study did not provide evidence that antibiotic mixing, compared with antibiotic cycling with 6-week cycling periods reduced the prevalence of carriage with antibiotic-resistant, Gram-negative bacteria in the ICU.
MRSA nares screening can be a stewardship tool to streamline empiric antibiotic therapy among those not nares colonized with MRSA.
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