Antibiotic

Piperacillin-Tazobactam vs Meropenem for Resistant Bloodstream Infections

Piperacillin-Tazobactam vs Meropenem for Resistant Bloodstream Infections

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For patients with Escherichia coli or Klebsiella pneumoniae bloodstream infections and ceftriaxone resistance, treatment with piperacillin-tazobactam compared with meropenem did not result in a non-inferior 30-day mortality.

Improved Documentation May Help Distinguish Beta-Lactam Allergy vs Intolerance

Improved Documentation May Help Distinguish Beta-Lactam Allergy vs Intolerance

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A documented β -lactam allergy was found in more than one-third of patients receiving broad-spectrum antibiotics, however, only 10% of patients were found to be truly allergic.

Initial Antibiotic Alternative for Uncomplicated Appendicitis

Initial Antibiotic Alternative for Uncomplicated Appendicitis

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The study included 530 patients, aged 18 to 60 years, with computed tomography-confirmed uncomplicated acute appendicitis.

High Rate of ED Visits for Children Linked With Antibiotic Adverse Effects

High Rate of ED Visits for Children Linked With Antibiotic Adverse Effects

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Many antibiotic adverse drug events led to emergency department visits, particularly among young children, highlighting a need for better communication regarding the risks of overprescribing.

Penicillin Allergies: Commonly Reported but Rarely Accurate

Penicillin Allergies: Commonly Reported but Rarely Accurate

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As infections from drug-resistant microbes continue to rise, the development of new antibiotics has declined since the golden age of antibiotic discovery in the mid-20th century.

NICU Antibiotic Use Rates Declined From 2013 to 2016

NICU Antibiotic Use Rates Declined From 2013 to 2016

Antibiotic use rates in neonatal intensive care units are declining.

ASM Microbe 2018 Update: Preserving Gram-Negative Antibiotics Through Better Diagnostics

ASM Microbe 2018 Update: Preserving Gram-Negative Antibiotics Through Better Diagnostics

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Neil Clancy, MD, from the VA Pittsburgh Health Care System, shares highlights from ASM Microbe 2018.

 Partial Oral Antibiotics Noninferior to Continuous IV in Left-Sided Endocarditis

Partial Oral Antibiotics Noninferior to Continuous IV in Left-Sided Endocarditis

Changing to oral antibiotics was non-inferior to continued intravenous antibiotic treatment

Evaluation of Appropriateness of Ceftriaxone Use in the Emergency Department

Evaluation of Appropriateness of Ceftriaxone Use in the Emergency Department

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Alternative antibiotics with a lower ecological impact were suggested for 55.2% of relevant ceftriaxone prescriptions in a university hospital emergency department setting during 2016.

FDA Approves Omadacycline for Skin Infections, Pneumonia

FDA Approves Omadacycline for Skin Infections, Pneumonia

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The Committee's recommendation was based on data from the omadacycline global development program that included nearly 2000 adults in three Phase 3 studies.

Continuous Antibiotic Infusion via Elastomeric Pumps Safe and Effective in Outpatients

Continuous Antibiotic Infusion via Elastomeric Pumps Safe and Effective in Outpatients

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Treating outpatients with continuous infusions of flucloxacillin, cefepime, vancomycin, and piperacillin/tazobactam using elastomeric pumps was effective and safe.

Inappropriate Prescribing of Antibiotics High in Urgent Care Centers

Inappropriate Prescribing of Antibiotics High in Urgent Care Centers

There is considerable variability in the proportion of visits at which antibiotics are prescribed among traditional medical and retail clinic settings.

FDA Strengthens Warnings for Fluoroquinolone Antibiotics

FDA Strengthens Warnings for Fluoroquinolone Antibiotics

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The labeling changes are based on a review of postmarketing adverse event reports found in the FDA Adverse Event Reporting System (FAERS) database and published medical literature.

Resistant <i>A Baumannii</i> Rose in Children From 1999 to 2012

Resistant A Baumannii Rose in Children From 1999 to 2012

Between 1999 and 2012, Acinetobacter baumannii antibiotic resistance increased in children.

Increased Need for Antibiotic Stewardship in Outpatient Settings

Increased Need for Antibiotic Stewardship in Outpatient Settings

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A review summarizes outpatient prescription practices and identifies factors that may influence physician prescribing behaviors.

Combating Medically Important Antibiotic Use in Food-Producing Animals

Combating Medically Important Antibiotic Use in Food-Producing Animals

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The new WHO guidelines restricts antibiotic use in animals for purposes of growth promotion as well as avoidance of use for disease prevention.

Antibiotic Innovation Is Losing Ground to Gram-Negative Bacteria

Antibiotic Innovation Is Losing Ground to Gram-Negative Bacteria

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Experts discuss antibiotic classes in development, which agents holds the most promise, and how to prevent further resistance.

Lower Risk of <i>C Difficile</i> Infection With Tetracycline Use

Lower Risk of C Difficile Infection With Tetracycline Use

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Researchers conducted a systemic review and meta-analysis to determine which antibiotics for systemic use were associated with the lowest risk of C difficile infection.

Long-Term Behavioral Interventions on Inappropriate Antibiotic Prescribing

Long-Term Behavioral Interventions on Inappropriate Antibiotic Prescribing

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Inappropriate prescribing of antibiotics is a contributing factor in antibiotic resistance.

IV Penicillin Safety in Those With Allergy History But Negative Skin Test

IV Penicillin Safety in Those With Allergy History But Negative Skin Test

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Repeated intravenous administration of penicillin antibiotics appears to be safe in patients with a reported penicillin allergy and a negative penicillin allergy test.

Microbiome Diversity in Respiratory Tract Linked to Airway Inflammation

Microbiome Diversity in Respiratory Tract Linked to Airway Inflammation

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Lower microbial diversity in the respiratory tract was linked with prophylactic antibiotic use and less airway inflammation in cystic fibrosis.

Vancomycin Vials Voluntarily Recalled for Glass Contamination

Vancomycin Vials Voluntarily Recalled for Glass Contamination

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Hospira is voluntarily recalling one lot of Vancomycin Hydrochloride for Injection after a confirmed customer reported of glass within a single vial.

Vabomere Antibiotic for CRE Better Than Best Available Tx

Vabomere Antibiotic for CRE Better Than Best Available Tx

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New data finds Vabomere, a combination antibiotic for the treatment of CRE infections as best available treatment.

Cephalosporin Oral Suspension to Be Discontinued in 2018

Cephalosporin Oral Suspension to Be Discontinued in 2018

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Ceftin Oral Suspension, an antibiotic, has been discontinued.

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