Antibiotics, Antimicrobial Resistance

Featured Article

Penicillin Allergies: Commonly Reported but Rarely Accurate

Penicillin Allergies: Commonly Reported but Rarely Accurate

As infections from drug-resistant microbes continue to rise, the development of new antibiotics has declined since the golden age of antibiotic discovery in the mid-20th century.

Latest News

Patient Develops Glandular Tularemia After Taking Care of Sick Cat

Patient Develops Glandular Tularemia After Taking Care of Sick Cat

The 68-year-old patient reported having a fever for 1 week followed by progressive, painful swelling on the right side of his neck for 2 months.

Prophylaxis With TMP-SMX Did Not Alter Risk for Non-UTI Infections

Prophylaxis With TMP-SMX Did Not Alter Risk for Non-UTI Infections

Daily prophylaxis with TMP-SMX was not associated with change in risk for skin and soft tissue or sino-pulmonary infections, or pharyngitis in children.

Low Recurrence With Shortened IV Abx Course in GBS Bacteremia

Low Recurrence With Shortened IV Abx Course in GBS Bacteremia

For infants with uncomplicated, late-onset GBS bacteremia, a shortened IV course of antibiotic therapy is sometimes prescribed and is associated with low rates of disease recurrence and treatment failure.

The Misuse of Antibiotics in Acute Pancreatitis Appears Widespread

The Misuse of Antibiotics in Acute Pancreatitis Appears Widespread

The inappropriate use of antibiotics as prophylaxis and treatment in acute pancreatitis is common, highlighting the efforts required for antibiotic stewardship.

Prophylactic Antibiotics May Not Be Helpful After Acute Stroke

Prophylactic Antibiotics May Not Be Helpful After Acute Stroke

In acute ischemic or hemorrhagic stroke, prophylactic antibiotics reduce the overall infection rate, but do not reduce the risk for pneumonia, death, or dependency.

Delafloxacin Equally Effective as Vancomycin/Aztreonam for Acute Bacterial, Skin Suture Infections

Delafloxacin Equally Effective as Vancomycin/Aztreonam for Acute Bacterial, Skin Suture Infections

Treatment with intravenous and oral delafloxacin, a fluoroquinolone antibiotic with gram-negative and gram-positive activity, was comparable to vancomycin/aztreonam in improving clinical signs and symptoms in acute bacterial and skin structure infections.

Antipseudomonal Monotherapy Efficacious in Pneumonia

Antipseudomonal Monotherapy Efficacious in Pneumonia

Antipseudomonal combination therapy has shown poorer efficacy than antipseudomonal monotherapy in individuals with suspected pseudomonal pneumonia.

Cure Rate of Intra-Abdominal Infection With Short vs Prolonged Therapy

Cure Rate of Intra-Abdominal Infection With Short vs Prolonged Therapy

No significant differences in clinical cure rates were observed between short-course and prolonged-course antimicrobial therapy in patients with intraabdominal infections.

Omadacycline Approved for Community-Acquired Bacterial Pneumonia, Skin Infections

Omadacycline Approved for Community-Acquired Bacterial Pneumonia, Skin Infections

The approval was based on Phase 3 data from 2 studies in ABSSSI, where treatment with Nuzyra was compared with linezolid, and 1 study in CABP comparing Nuzyra with moxifloxacin. Across all 3 trials, Nuzyra was found to be effective and generally safe and well-tolerated.

Probiotic Use May Not Protect Against Clostridium Difficile Infection

Probiotic Use May Not Protect Against Clostridium Difficile Infection

In patients taking multiple antibiotics, proton pump inhibitors, or histamine receptor antagonists, the concurrent use of probiotics was associated with an increased incidence of Clostridium difficile infection

Sign Up for Free e-newsletters