A novel service to target appropriate antimicrobial prescription and improve antibiotic stewardship shows potential according.
Adding glycopeptide to the spacer in 2-stage exchange procedures for periprosthetic joint infections reduces positive cultures during re-implantation.
Almost half of parents report saving leftover antibiotics, and almost three-quarters of these parents subsequently divert the antibiotics.
Despite notable advances in medical care, infections due to Pseudomonas aeruginosa remain problematic and are a major public health concern.
Prescription of antibiotics, acid-suppressing meds in first two years of life linked to childhood obesity.
A merger of data from 2 reviews found no place for antibiotics in adults with uncomplicated acute rhinosinusitis.
Probiotics provided to reduce the risk for common acute infections may be associated with reduced antibiotic use in infants and children.
There is considerable variability in the geographic availability of antibiotics.
Patients with Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae infections have multisystem disease and exposure to carbapenems and aminoglycosides.
The 68-year-old patient reported having a fever for 1 week followed by progressive, painful swelling on the right side of his neck for 2 months.
For infants with uncomplicated, late-onset GBS bacteremia, a shortened IV course of antibiotic therapy is sometimes prescribed and is associated with low rates of disease recurrence and treatment failure.
Daily prophylaxis with TMP-SMX was not associated with change in risk for skin and soft tissue or sino-pulmonary infections, or pharyngitis in children.
The inappropriate use of antibiotics as prophylaxis and treatment in acute pancreatitis is common, highlighting the efforts required for antibiotic stewardship.
In acute ischemic or hemorrhagic stroke, prophylactic antibiotics reduce the overall infection rate, but do not reduce the risk for pneumonia, death, or dependency.
Antipseudomonal combination therapy has shown poorer efficacy than antipseudomonal monotherapy in individuals with suspected pseudomonal pneumonia.
Treatment with intravenous and oral delafloxacin, a fluoroquinolone antibiotic with gram-negative and gram-positive activity, was comparable to vancomycin/aztreonam in improving clinical signs and symptoms in acute bacterial and skin structure infections.
No significant differences in clinical cure rates were observed between short-course and prolonged-course antimicrobial therapy in patients with intraabdominal infections.
The approval was based on Phase 3 data from 2 studies in ABSSSI, where treatment with Nuzyra was compared with linezolid, and 1 study in CABP comparing Nuzyra with moxifloxacin. Across all 3 trials, Nuzyra was found to be effective and generally safe and well-tolerated.
In patients taking multiple antibiotics, proton pump inhibitors, or histamine receptor antagonists, the concurrent use of probiotics was associated with an increased incidence of Clostridium difficile infection
The combination of daptomycin with fosfomycin demonstrates increased efficacy in treating methicillin-resistant Staphylococcus aureus bacteremia compared with daptomycin alone.
A recent report published in the Journal of Pharmacy Practice describes the case of a 75-year-old female patient who developed acquired hemophilia following levofloxacin administration.
These findings may highlight physician difficulty explaining to patients why antibiotics are not required.
Oral ciprofloxacin has been found to be an effective option for gram-negative bacteremia treatment.
The use of a moderate to low susceptibility antibiotic to treat a urinary tract infection [UTI] may result in a 1.74-fold increase in the odds of an emergency department readmission within 30 days for another UTI.
New data suggest an association between general practitioners' prescribing habits for urinary tract infections and UTI-related E coli bacteremia incidence.
Single doses of ceftolozane and tazobactam were well tolerated in children with gram-negative bacterial infections and no safety concerns were identified.
Eravacycline was well-tolerated in clinical trials and achieved high cure rates in patients with Gram-negative pathogens (including resistant strains).
An algorithm based on risk factors for resistant pathogens and illness severity can simplify pneumonia treatment, improve the accuracy of empiric therapy, reduce mortality, and help avoid overusing broad spectrum therapy in some patients.
Nonsusceptibility to first-line antibiotics is associated with decreased survival in gram-negative bloodstream infections.
The FDA is warning patients with cancers of the blood or lymph nodes who undergo a donor stem cell transplant not to take azithromycin,
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