Antibiotics

Infections Linked to Increased Later Risk for Mental Disorders

Infections Linked to Increased Later Risk for Mental Disorders

Subsequent risk increased with infections requiring hospitalization, treatment with anti-infective agents.

Polymyxin B Hemoperfusion Does Not Change Mortality Rate in Septic Shock

Polymyxin B Hemoperfusion Does Not Change Mortality Rate in Septic Shock

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For patients with septic shock and high circulating endotoxin levels, adding polymyxin B hemoperfusion treatment did not improve 28-day mortality rate.

Topical 15% Paromomycin-Aquaphilic Effective For New World Leishmaniasis

Topical 15% Paromomycin-Aquaphilic Effective For New World Leishmaniasis

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Treatment for cutaneous leishmaniasis caused by Leishmania braziliensis, using 15% paromomycin-Aquaphilic, was superior to a negative vehicle control.

Susceptibility of <i>C botulinum</i> and <i>C baratii</i> to Antimicrobials

Susceptibility of C botulinum and C baratii to Antimicrobials

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Nearly all isolates from infants with botulism in Californian are susceptible to most clinically used antibiotics.

Addiction Medicine Consultation Improves Antibiotic Compliance in Patients with Opioid Use Disorders

Addiction Medicine Consultation Improves Antibiotic Compliance in Patients with Opioid Use Disorders

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Patients with opioid use disorders who required hospitalization with lengthy antibiotic therapy had better outcomes with addiction medicine consultation.

Topical Antibacterial Agent Effective for Treatment of Impetigo

Topical Antibacterial Agent Effective for Treatment of Impetigo

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Investigators examined tolerability, effectiveness, and safety profile of topical antibacterial agent ozenoxacin in adults and children with impetigo.

Re-Assessing Renal Dose Adjustments of Antibiotics: Expert Q&A

Re-Assessing Renal Dose Adjustments of Antibiotics: Expert Q&A

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For patients with serious infectious diseases, the first 48 hours represent a critical window for antibiotic administration.

Early Antibiotic Use May Be Tied to Childhood Weight Gain

Early Antibiotic Use May Be Tied to Childhood Weight Gain

Antibiotic use in children <24 months of age is associated with a slightly higher body weight at 5 years of age.

Rifampin Resistance Emerges After Rifaximin Use

Rifampin Resistance Emerges After Rifaximin Use

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A transient resistance to rifampin may emerge in patients after taking rifaximin.

6-Week Antibiotic Treatment Effective for Spinal Surgery Site Infections

6-Week Antibiotic Treatment Effective for Spinal Surgery Site Infections

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Six-week antibiotic treatment is sufficient for early, spinal surgery site infections.

Amoxicillin-Clavulanate Vs Azithromycin for Children With Bronchiectasis

Amoxicillin-Clavulanate Vs Azithromycin for Children With Bronchiectasis

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Azithromycin and amoxicillin-clavulanate are equally effective for resolving nonsevere bronchiectasis in children.

Novel Point of Care Respiratory Viral Testing Service Shows Potential

Novel Point of Care Respiratory Viral Testing Service Shows Potential

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A novel service to target appropriate antimicrobial prescription and improve antibiotic stewardship shows potential according.

Antibiotics and Failure Rates During 2-Stage Exchange Arthroplasty

Antibiotics and Failure Rates During 2-Stage Exchange Arthroplasty

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Adding glycopeptide to the spacer in 2-stage exchange procedures for periprosthetic joint infections reduces positive cultures during re-implantation.

AAP: Parents Frequently Save Leftover Antibiotics

AAP: Parents Frequently Save Leftover Antibiotics

Almost half of parents report saving leftover antibiotics, and almost three-quarters of these parents subsequently divert the antibiotics.

Treating <i>Pseudomonas aeruginosa</i> Infections: Highlights From IDWeek 2018

Treating Pseudomonas aeruginosa Infections: Highlights From IDWeek 2018

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Despite notable advances in medical care, infections due to Pseudomonas aeruginosa remain problematic and are a major public health concern.

Fofomycin Injection: New Drug Application for Treatment of Complicated UTI

Fofomycin Injection: New Drug Application for Treatment of Complicated UTI

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Contepo, an investigational epoxide intravenous (IV) antibiotic, has broad spectrum activity against Gram-negative and Gram-positive pathogens, including multi-drug resistant strains such as ESBL-producing Enterobacteriaceae.

Antibiotics, Acid Suppressants in Infancy May Up Obesity Risk

Antibiotics, Acid Suppressants in Infancy May Up Obesity Risk

Prescription of antibiotics, acid-suppressing meds in first two years of life linked to childhood obesity.

Antibiotics Provide Marginal Benefits in Adults With Acute Rhinosinusitis

Antibiotics Provide Marginal Benefits in Adults With Acute Rhinosinusitis

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A merger of data from 2 reviews found no place for antibiotics in adults with uncomplicated acute rhinosinusitis.

Probiotics May Reduce Antibiotic Use for Common Acute Infections in Children

Probiotics May Reduce Antibiotic Use for Common Acute Infections in Children

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Probiotics provided to reduce the risk for common acute infections may be associated with reduced antibiotic use in infants and children.

Variability in Geographic Availability of New Antibiotics

Variability in Geographic Availability of New Antibiotics

There is considerable variability in the geographic availability of antibiotics.

Epidemiology of <i>K pneumoniae</i> Carbapenemase-Producing Enterobacteriaceae Infections in Children

Epidemiology of K pneumoniae Carbapenemase-Producing Enterobacteriaceae Infections in Children

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Patients with Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae infections have multisystem disease and exposure to carbapenems and aminoglycosides.

Piperacillin-Tazobactam vs Meropenem for Resistant Bloodstream Infections

Piperacillin-Tazobactam vs Meropenem for Resistant Bloodstream Infections

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For patients with Escherichia coli or Klebsiella pneumoniae bloodstream infections and ceftriaxone resistance, treatment with piperacillin-tazobactam compared with meropenem did not result in a non-inferior 30-day mortality.

Patient Develops Glandular Tularemia After Taking Care of Sick Cat

Patient Develops Glandular Tularemia After Taking Care of Sick Cat

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The 68-year-old patient reported having a fever for 1 week followed by progressive, painful swelling on the right side of his neck for 2 months.

Low Recurrence With Shortened IV Abx Course in GBS Bacteremia

Low Recurrence With Shortened IV Abx Course in GBS Bacteremia

For infants with uncomplicated, late-onset GBS bacteremia, a shortened IV course of antibiotic therapy is sometimes prescribed and is associated with low rates of disease recurrence and treatment failure.

Prophylaxis With TMP-SMX Did Not Alter Risk for Non-UTI Infections

Prophylaxis With TMP-SMX Did Not Alter Risk for Non-UTI Infections

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Daily prophylaxis with TMP-SMX was not associated with change in risk for skin and soft tissue or sino-pulmonary infections, or pharyngitis in children.

The Misuse of Antibiotics in Acute Pancreatitis Appears Widespread

The Misuse of Antibiotics in Acute Pancreatitis Appears Widespread

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The inappropriate use of antibiotics as prophylaxis and treatment in acute pancreatitis is common, highlighting the efforts required for antibiotic stewardship.

Prophylactic Antibiotics May Not Be Helpful After Acute Stroke

Prophylactic Antibiotics May Not Be Helpful After Acute Stroke

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In acute ischemic or hemorrhagic stroke, prophylactic antibiotics reduce the overall infection rate, but do not reduce the risk for pneumonia, death, or dependency.

Antipseudomonal Monotherapy Efficacious in Pneumonia

Antipseudomonal Monotherapy Efficacious in Pneumonia

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Antipseudomonal combination therapy has shown poorer efficacy than antipseudomonal monotherapy in individuals with suspected pseudomonal pneumonia.

Delafloxacin Equally Effective as Vancomycin/Aztreonam for Acute Bacterial, Skin Suture Infections

Delafloxacin Equally Effective as Vancomycin/Aztreonam for Acute Bacterial, Skin Suture Infections

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Treatment with intravenous and oral delafloxacin, a fluoroquinolone antibiotic with gram-negative and gram-positive activity, was comparable to vancomycin/aztreonam in improving clinical signs and symptoms in acute bacterial and skin structure infections.

Cure Rate of Intra-Abdominal Infection With Short vs Prolonged Therapy

Cure Rate of Intra-Abdominal Infection With Short vs Prolonged Therapy

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No significant differences in clinical cure rates were observed between short-course and prolonged-course antimicrobial therapy in patients with intraabdominal infections.

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