antibiotics

Novel Point of Care Respiratory Viral Testing Service Shows Potential

Novel Point of Care Respiratory Viral Testing Service Shows Potential

By

A novel service to target appropriate antimicrobial prescription and improve antibiotic stewardship shows potential according.

Antibiotics and Failure Rates During 2-Stage Exchange Arthroplasty

Antibiotics and Failure Rates During 2-Stage Exchange Arthroplasty

By

Adding glycopeptide to the spacer in 2-stage exchange procedures for periprosthetic joint infections reduces positive cultures during re-implantation.

AAP: Parents Frequently Save Leftover Antibiotics

AAP: Parents Frequently Save Leftover Antibiotics

Almost half of parents report saving leftover antibiotics, and almost three-quarters of these parents subsequently divert the antibiotics.

Treating <i>Pseudomonas aeruginosa</i> Infections: Highlights From IDWeek 2018

Treating Pseudomonas aeruginosa Infections: Highlights From IDWeek 2018

By

Despite notable advances in medical care, infections due to Pseudomonas aeruginosa remain problematic and are a major public health concern.

Antibiotics, Acid Suppressants in Infancy May Up Obesity Risk

Antibiotics, Acid Suppressants in Infancy May Up Obesity Risk

Prescription of antibiotics, acid-suppressing meds in first two years of life linked to childhood obesity.

Antibiotics Provide Marginal Benefits in Adults With Acute Rhinosinusitis

Antibiotics Provide Marginal Benefits in Adults With Acute Rhinosinusitis

By

A merger of data from 2 reviews found no place for antibiotics in adults with uncomplicated acute rhinosinusitis.

Probiotics May Reduce Antibiotic Use for Common Acute Infections in Children

Probiotics May Reduce Antibiotic Use for Common Acute Infections in Children

By

Probiotics provided to reduce the risk for common acute infections may be associated with reduced antibiotic use in infants and children.

Variability in Geographic Availability of New Antibiotics

Variability in Geographic Availability of New Antibiotics

There is considerable variability in the geographic availability of antibiotics.

Epidemiology of <i>K pneumoniae</i> Carbapenemase-Producing Enterobacteriaceae Infections in Children

Epidemiology of K pneumoniae Carbapenemase-Producing Enterobacteriaceae Infections in Children

By

Patients with Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae infections have multisystem disease and exposure to carbapenems and aminoglycosides.

Patient Develops Glandular Tularemia After Taking Care of Sick Cat

Patient Develops Glandular Tularemia After Taking Care of Sick Cat

By

The 68-year-old patient reported having a fever for 1 week followed by progressive, painful swelling on the right side of his neck for 2 months.

Low Recurrence With Shortened IV Abx Course in GBS Bacteremia

Low Recurrence With Shortened IV Abx Course in GBS Bacteremia

For infants with uncomplicated, late-onset GBS bacteremia, a shortened IV course of antibiotic therapy is sometimes prescribed and is associated with low rates of disease recurrence and treatment failure.

Prophylaxis With TMP-SMX Did Not Alter Risk for Non-UTI Infections

Prophylaxis With TMP-SMX Did Not Alter Risk for Non-UTI Infections

By

Daily prophylaxis with TMP-SMX was not associated with change in risk for skin and soft tissue or sino-pulmonary infections, or pharyngitis in children.

The Misuse of Antibiotics in Acute Pancreatitis Appears Widespread

The Misuse of Antibiotics in Acute Pancreatitis Appears Widespread

By

The inappropriate use of antibiotics as prophylaxis and treatment in acute pancreatitis is common, highlighting the efforts required for antibiotic stewardship.

Prophylactic Antibiotics May Not Be Helpful After Acute Stroke

Prophylactic Antibiotics May Not Be Helpful After Acute Stroke

By

In acute ischemic or hemorrhagic stroke, prophylactic antibiotics reduce the overall infection rate, but do not reduce the risk for pneumonia, death, or dependency.

Antipseudomonal Monotherapy Efficacious in Pneumonia

Antipseudomonal Monotherapy Efficacious in Pneumonia

By

Antipseudomonal combination therapy has shown poorer efficacy than antipseudomonal monotherapy in individuals with suspected pseudomonal pneumonia.

Delafloxacin Equally Effective as Vancomycin/Aztreonam for Acute Bacterial, Skin Suture Infections

Delafloxacin Equally Effective as Vancomycin/Aztreonam for Acute Bacterial, Skin Suture Infections

By

Treatment with intravenous and oral delafloxacin, a fluoroquinolone antibiotic with gram-negative and gram-positive activity, was comparable to vancomycin/aztreonam in improving clinical signs and symptoms in acute bacterial and skin structure infections.

Cure Rate of Intra-Abdominal Infection With Short vs Prolonged Therapy

Cure Rate of Intra-Abdominal Infection With Short vs Prolonged Therapy

By

No significant differences in clinical cure rates were observed between short-course and prolonged-course antimicrobial therapy in patients with intraabdominal infections.

Omadacycline Approved for  Community-Acquired Bacterial Pneumonia, Skin Infections

Omadacycline Approved for Community-Acquired Bacterial Pneumonia, Skin Infections

By

The approval was based on Phase 3 data from 2 studies in ABSSSI, where treatment with Nuzyra was compared with linezolid, and 1 study in CABP comparing Nuzyra with moxifloxacin. Across all 3 trials, Nuzyra was found to be effective and generally safe and well-tolerated.

Probiotic Use May Not Protect Against <i>Clostridium Difficile</i> Infection

Probiotic Use May Not Protect Against Clostridium Difficile Infection

By

In patients taking multiple antibiotics, proton pump inhibitors, or histamine receptor antagonists, the concurrent use of probiotics was associated with an increased incidence of Clostridium difficile infection

Daptomycin Plus Fosfomycin More Effective Than Daptomycin Monotherapy in MRSA Bacteremia

Daptomycin Plus Fosfomycin More Effective Than Daptomycin Monotherapy in MRSA Bacteremia

By

The combination of daptomycin with fosfomycin demonstrates increased efficacy in treating methicillin-resistant Staphylococcus aureus bacteremia compared with daptomycin alone.

Patient Develops Acquired Hemophilia After Treatment With Levofloxacin

Patient Develops Acquired Hemophilia After Treatment With Levofloxacin

By

A recent report published in the Journal of Pharmacy Practice describes the case of a 75-year-old female patient who developed acquired hemophilia following levofloxacin administration.

Prescribing Antibiotics Shortens Telemedicine Visits for Respiratory Tract Infections

Prescribing Antibiotics Shortens Telemedicine Visits for Respiratory Tract Infections

These findings may highlight physician difficulty explaining to patients why antibiotics are not required.

Oral Ciprofloxacin Effective in Treatment for Bacteremia

Oral Ciprofloxacin Effective in Treatment for Bacteremia

By

Oral ciprofloxacin has been found to be an effective option for gram-negative bacteremia treatment.

High Susceptibility Antibiotics Reduce Readmission Rates for Urinary Tract Infections

High Susceptibility Antibiotics Reduce Readmission Rates for Urinary Tract Infections

By

The use of a moderate to low susceptibility antibiotic to treat a urinary tract infection [UTI] may result in a 1.74-fold increase in the odds of an emergency department readmission within 30 days for another UTI.

Relationships Between Prescribing for UTI, <i>E coli</i> Bacteremia, Resistance

Relationships Between Prescribing for UTI, E coli Bacteremia, Resistance

By

New data suggest an association between general practitioners' prescribing habits for urinary tract infections and UTI-related E coli bacteremia incidence.

Pediatric Phase 1 Trial Shows Ceftolozane/Tazobactam Is Safe,Tolerable

Pediatric Phase 1 Trial Shows Ceftolozane/Tazobactam Is Safe,Tolerable

By

Single doses of ceftolozane and tazobactam were well tolerated in children with gram-negative bacterial infections and no safety concerns were identified.

Eravacycline Approved for the Treatment of Complicated Intra-Abdominal Infections

Eravacycline Approved for the Treatment of Complicated Intra-Abdominal Infections

By

Eravacycline was well-tolerated in clinical trials and achieved high cure rates in patients with Gram-negative pathogens (including resistant strains).

Therapeutic Algorithm May Guide Empiric Therapy in Pneumonia

Therapeutic Algorithm May Guide Empiric Therapy in Pneumonia

By

An algorithm based on risk factors for resistant pathogens and illness severity can simplify pneumonia treatment, improve the accuracy of empiric therapy, reduce mortality, and help avoid overusing broad spectrum therapy in some patients.

New Designation for Some Gram-Negative Bacteremia Increases Treatment Options

New Designation for Some Gram-Negative Bacteremia Increases Treatment Options

By

Nonsusceptibility to first-line antibiotics is associated with decreased survival in gram-negative bloodstream infections.

FDA Warns Against Long-Term Azithromycin Use for Some

FDA Warns Against Long-Term Azithromycin Use for Some

The FDA is warning patients with cancers of the blood or lymph nodes who undergo a donor stem cell transplant not to take azithromycin,

Sign Up for Free e-newsletters