Antimicrobial Resistance

Susceptibility of <i>C botulinum</i> and <i>C baratii</i> to Antimicrobials

Susceptibility of C botulinum and C baratii to Antimicrobials

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Nearly all isolates from infants with botulism in Californian are susceptible to most clinically used antibiotics.

Cefiderocol Noninferior to Imipenem-Cilastatin in Those at High Risk for Multidrug Resistance UTI

Cefiderocol Noninferior to Imipenem-Cilastatin in Those at High Risk for Multidrug Resistance UTI

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Cefiderocol was noninferior to imipenem-cilastatin in patients with complicated UTI who were at risk for multidrug-resistant infections.

Rifampin Resistance Emerges After Rifaximin Use

Rifampin Resistance Emerges After Rifaximin Use

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A transient resistance to rifampin may emerge in patients after taking rifaximin.

Antibiotic-Resistant Enterobacteriaceae Tied to Clinical Failure in UTI

Antibiotic-Resistant Enterobacteriaceae Tied to Clinical Failure in UTI

Poor clinical outcomes linked to extended spectrum cephalosporin-resistant Enterobacteriaceae.

Treating <i>Pseudomonas aeruginosa</i> Infections: Highlights From IDWeek 2018

Treating Pseudomonas aeruginosa Infections: Highlights From IDWeek 2018

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Despite notable advances in medical care, infections due to Pseudomonas aeruginosa remain problematic and are a major public health concern.

Piperacillin-Tazobactam for ESBL Bloodstream Infection, Insights From the MERINO Trial

Piperacillin-Tazobactam for ESBL Bloodstream Infection, Insights From the MERINO Trial

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Resistance of gram negative bacteria to some cephalosporins has emerged as a significant threat over the last few decades as a results of ESBL enzymes.

Epidemiology of <i>K pneumoniae</i> Carbapenemase-Producing Enterobacteriaceae Infections in Children

Epidemiology of K pneumoniae Carbapenemase-Producing Enterobacteriaceae Infections in Children

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Patients with Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae infections have multisystem disease and exposure to carbapenems and aminoglycosides.

Piperacillin-Tazobactam vs Meropenem for Resistant Bloodstream Infections

Piperacillin-Tazobactam vs Meropenem for Resistant Bloodstream Infections

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For patients with Escherichia coli or Klebsiella pneumoniae bloodstream infections and ceftriaxone resistance, treatment with piperacillin-tazobactam compared with meropenem did not result in a non-inferior 30-day mortality.

Risk Factors for Multidrug-Resistant Pathogens in Pneumonia

Risk Factors for Multidrug-Resistant Pathogens in Pneumonia

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Previous antibiotic use and mechanical invasive ventilation were risk factors for multidrug-resistant pathogens in hospital-associated or ventilator-associated pneumonia.

Relationships Between Prescribing for UTI, <i>E coli</i> Bacteremia, Resistance

Relationships Between Prescribing for UTI, E coli Bacteremia, Resistance

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New data suggest an association between general practitioners' prescribing habits for urinary tract infections and UTI-related E coli bacteremia incidence.

High Rate of ED Visits for Children Linked With Antibiotic Adverse Effects

High Rate of ED Visits for Children Linked With Antibiotic Adverse Effects

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Many antibiotic adverse drug events led to emergency department visits, particularly among young children, highlighting a need for better communication regarding the risks of overprescribing.

Minimum Inhibitory Concentrations May Predict Risk of Relapse in Tuberculosis

Minimum Inhibitory Concentrations May Predict Risk of Relapse in Tuberculosis

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Higher minimum inhibitory concentration values of isoniazid or rifampin are associated with a greater risk of relapse in drug-susceptible tuberculosis than lower MICs.

Penicillin Allergies: Commonly Reported but Rarely Accurate

Penicillin Allergies: Commonly Reported but Rarely Accurate

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As infections from drug-resistant microbes continue to rise, the development of new antibiotics has declined since the golden age of antibiotic discovery in the mid-20th century.

ASM Microbe 2018 Update: Preserving Gram-Negative Antibiotics Through Better Diagnostics

ASM Microbe 2018 Update: Preserving Gram-Negative Antibiotics Through Better Diagnostics

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Neil Clancy, MD, from the VA Pittsburgh Health Care System, shares highlights from ASM Microbe 2018.

Relapse-Free Cure From MDR-TB Higher Than Anticipated

Relapse-Free Cure From MDR-TB Higher Than Anticipated

The frequency of relapse-free cure from multidrug-resistant tuberculosis is higher than previously anticipated.

Gram-Negative Bacteria Antibiotic Susceptibility for Pneumonia in the ICU

Gram-Negative Bacteria Antibiotic Susceptibility for Pneumonia in the ICU

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Antimicrobial agents ceftazidime/avibactam and amikacin provided the best overall coverage against Gram-negative organisms isolated from patients with pneumonia in the ICU.

New Designation for Some Gram-Negative Bacteremia Increases Treatment Options

New Designation for Some Gram-Negative Bacteremia Increases Treatment Options

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Nonsusceptibility to first-line antibiotics is associated with decreased survival in gram-negative bloodstream infections.

Examining the Prevalence of Prescribing Contraindicated Antimicrobials

Examining the Prevalence of Prescribing Contraindicated Antimicrobials

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Researchers performed a cross-sectional study that included multiple year pooled data (2003 to 2011) from the National Ambulatory Medical Care Survey and the National Hospital Ambulatory Medical Care Survey.

Resistance to Antibiotic Treatments for <i>H pylori</i> Infection

Resistance to Antibiotic Treatments for H pylori Infection

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The resistance of Helicobacter pylori to antibiotics is increasing worldwide, with primary and secondary resistance to clarithromycin, metronidazole, and levofloxacin reaching levels higher than 15%.

Some Bacteria Now More Tolerant of Alcohol-Based Sanitizers

Some Bacteria Now More Tolerant of Alcohol-Based Sanitizers

Some types of bacteria are developing tolerance of alcohol-based hand sanitizers used in hospitals.

Prevalence of Resistant Urinary Tract Infections Outpacing Antimicrobial Treatment

Prevalence of Resistant Urinary Tract Infections Outpacing Antimicrobial Treatment

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Approximately 6% of all patients presenting at an emergency department during a one year period with a UTI were diagnosed with an ESBL-producing Enterobacteriaceae infection.

Risk Factors for <i>Enterobacteriaceae</i> Bacteremia Identified

Risk Factors for Enterobacteriaceae Bacteremia Identified

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Extended-spectrum β-lactamase-producing Enterobacteriaceae in urine or feces is a substantial risk factor for subsequent EPE-bloodstream infection.

<i>E. coli</i> Subclone Responsible for Prescription Errors in Urgent Care Clinic

E. coli Subclone Responsible for Prescription Errors in Urgent Care Clinic

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The majority of mismatched prescribed antibiotics for suspected UTI at an urgent care clinic among patients 70+ years old or with diabetes or urinary catheterization is likely the result of the multidrug-resistant H30 subclone of Escherichia coli ST131.

Rapid Expansion of Multidrug Resistant <i>E. Coli</i> Clone ST1193 in the United States

Rapid Expansion of Multidrug Resistant E. Coli Clone ST1193 in the United States

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A new multi-drug resistant clone of Escherichia coli — ST1193 — has emerged in multiple US cities.

Ceftazidime/Avibactam an Effective Option in Serious Gram-Negative Infections

Ceftazidime/Avibactam an Effective Option in Serious Gram-Negative Infections

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Ceftazidime/avibactam could be a suitable alternative to carbapenem-based regimens for certain serious Gram-negative infections.

Antibiotic Selection Pressure Causally Linked to Macrolide Resistome

Antibiotic Selection Pressure Causally Linked to Macrolide Resistome

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Communities randomly assigned to less frequent antibiotic use had significantly lower prevalence of genetic antibiotic resistance determinants.

No Reduction in Antibiotic Use With Procalcitonin-Guided Therapy in the ED

No Reduction in Antibiotic Use With Procalcitonin-Guided Therapy in the ED

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Procalcitonin-guided therapy did not reduce the number of antibiotic prescriptions among patients presenting to the ED with fever.

Generic Quality Indicators Developed for Responsible Antibiotic Usage

Generic Quality Indicators Developed for Responsible Antibiotic Usage

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A study was conducted with a goal of developing a set of generic quality indicators for the safe and appropriate use of antibiotic agents.

Resistant <i>A Baumannii</i> Rose in Children From 1999 to 2012

Resistant A Baumannii Rose in Children From 1999 to 2012

Between 1999 and 2012, Acinetobacter baumannii antibiotic resistance increased in children.

Rapid Diagnostics Reduce Time to Optimal Antimicrobial Therapy in Children

Rapid Diagnostics Reduce Time to Optimal Antimicrobial Therapy in Children

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Time to optimal antimicrobial therapy for positive blood cultures was assessed in a pediatric population.

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