As infections from drug-resistant microbes continue to rise, the development of new antibiotics has declined since the golden age of antibiotic discovery in the mid-20th century.
Neil Clancy, MD, from the VA Pittsburgh Health Care System, shares highlights from ASM Microbe 2018.
The frequency of relapse-free cure from multidrug-resistant tuberculosis is higher than previously anticipated.
Nonsusceptibility to first-line antibiotics is associated with decreased survival in gram-negative bloodstream infections.
Researchers performed a cross-sectional study that included multiple year pooled data (2003 to 2011) from the National Ambulatory Medical Care Survey and the National Hospital Ambulatory Medical Care Survey.
Some types of bacteria are developing tolerance of alcohol-based hand sanitizers used in hospitals.
Approximately 6% of all patients presenting at an emergency department during a one year period with a UTI were diagnosed with an ESBL-producing Enterobacteriaceae infection.
A new multi-drug resistant clone of Escherichia coli — ST1193 — has emerged in multiple US cities.
Communities randomly assigned to less frequent antibiotic use had significantly lower prevalence of genetic antibiotic resistance determinants.
Procalcitonin-guided therapy did not reduce the number of antibiotic prescriptions among patients presenting to the ED with fever.
A study was conducted with a goal of developing a set of generic quality indicators for the safe and appropriate use of antibiotic agents.
Between 1999 and 2012, Acinetobacter baumannii antibiotic resistance increased in children.
A study evaluated whether uncomplicated UTIs in women could be treated without antibiotics.
Researchers found no association between starting colistin before final culture results and survival at 14 and 28 days.
While macrolides had no direct effect on lung function, their use significantly improved asthma control and quality of life in patients with asthma.
Children deemed low risk who were tested for penicillin allergy tolerated the medication within the following year without serious adverse or allergic reactions.
Use of certain antibiotics may be contributing to the rise of kidney stones among children and adults.
The 36 recalled lots were manufactured by Hospira and marketed by Apotex.
Five-day nitrofurantoin may be a better alternative than single-dose fosfomycin for treating uncomplicated UTI in women.
Findings do not provide evidence that antibiotic mixing, compared with antibiotic cycling with 6-week cycling periods, with third-generation or fourth-generation cephalosporins, piperacillin-tazobactam, and carbapenems reduces the prevalence of carriage with antibiotic-resistant, Gram-negative bacteria in the ICU.
Cross-sectional survey represents the first assessment of antimicrobial prescription practices for prophylaxis in pediatric patients hospitalized worldwide.
The need for innovative new infection prevention programs, antibiotics, and vaccines to prevent and treat antibiotic-resistant infections is an international priority.
Early aggressive action should be taken to prevent the spread of bacteria harboring unusual resistance genes.
The use of acid-suppressive medications and antibiotics during the first 6 months of infancy is tied to subsequent development of allergic disease.
The potential role of vaccinations in combatting antimicrobial resistance (AMR) is currently undervalued. The distribution and development of new vaccines should be priorities in efforts to address the AMR crisis.
The new WHO guidelines restricts antibiotic use in animals for purposes of growth promotion as well as avoidance of use for disease prevention.
Findings from the study did not provide evidence that antibiotic mixing, compared with antibiotic cycling with 6-week cycling periods reduced the prevalence of carriage with antibiotic-resistant, Gram-negative bacteria in the ICU.
Evaluating treatment with meropenem/vaborbactam to piperacillin-tazobactam in patients with complicated UTIs.
The recommendation was made after the FDA reviewed the results of a 10-year follow-up of the CLARICOR trial, which investigated the effects of clarithromycin in patients with stable coronary heart disease.
Investigators identified patient, provider, and practice characteristics associated with antibiotic prescribing in an attempt to determine factors contributing to inappropriate antimicrobial use.
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