Barry Greenberg

General (including evidence of efficacy) Ivabradine (Corlanor®) is a novel selective inhibitor of the I f channel current in the pacemaker cells of the sinoatrial (SA) node. Its predominant effect is to reduce heart rate without affecting contractility. Heart rate reduction with beta blockers has been identified in clinical literature and trials as a contributor…

General (including evidence of efficacy) LCZ696 (sacubitril/valsartan) is a member of a new class of agents called angiotensin receptor-neprilysin inhibitors (ARNIs) which combine a neprilysin inhibitor and angiotensin receptor blocker (ARB). LCZ696 is currently indicated for treating patients with heart failure with reduced ejection fraction (HFrEF) in place of an angiotensin converting enzyme (ACE) inhibitor…