Joseph Sweeney John Reagan, Author at Infectious Disease Advisor

Joseph Sweeney John Reagan

All articles by Joseph Sweeney John Reagan

Cold agglutinin disease

Cold agglutinin disease What every physician needs to know: Cold agglutinin disease (CAD) is a rare (approximately 1:100,000) disorder in which a red cell autoantibody, primarily IgM (immunoglobulin M), fixes complement in vivo. Complement fixation preferentially occurs at temperatures below 37°C, hence the term CAD. This results in mostly extravascular hemolytic anemia, but intravascular hemolysis…

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