Joyce Lee, PharmD, RPh

This is the first prospective investigation comparing the efficacy and tolerability of 2 treatments for nitroimidazole-refractory giardiasis in international travelers.

Because outcomes of appendectomy vary by patient age, family income, and transfer status, the researchers compared outcomes in these subgroups.

Investigators sought to determine the safety, tolerability, and efficacy of arterolane-piperaquine-mefloquine triple therapy vs arterolane-piperaquine and artemether-lumefantrine for uncomplicated Plasmodium falciparum malaria in children.

A safety review evaluated several studies assessing the safety of PrEP in pregnant women, including the Partners PrEP Study, TDF2 Study, FEM-PrEP, and VOICE.

A team of investigators sought to determine factors affecting response to
fostemsavir-based treatment regimens in patients with HIV-1 infection.

Researchers assessed antibiotic de-escalation practices across hospitals and their associations with outcomes in hospitalized patients with pneumonia who have negative cultures.

A team of researchers sought to identify the incidence, antimicrobial susceptibilities, and outcomes associated with bacterial and fungal secondary infections in a large cohort of patients with COVID-19.

A team of investigators evaluated outcomes following probiotic use for primary prevention of Clostridioides difficile infection in hospitalized patients.

A team of investigators sought to assess the impact of Clostridioides difficile infection on outcomes in pediatric patients with cancer.

A team of investigators conducted a systematic review to determine the bioavailability of oral antibiotics during the initial phase of a systemic infection in hospitalized patients.

A retrospective cohort study was conducted to assess tolerability, side effects, and outcomes following treatment with low-dose amikacin in patients with multidrug-resistant tuberculosis.

Investigators conducted a prospective study to assess rates of completion of screening and preventive therapy for latent tuberculosis infection.

A team of investigators conducted a multicenter, retrospective, pooled cohort study to assess outcomes following short and prolonged duration of antimicrobial therapy in patients with low risk methicillin-susceptible Staphylococcus aureus bacteremia.

A randomized, open-label, noncomparative study was conducted at primary care HIV community clinics to assess outcomes following treatment with cefixime or penicillin for syphilis.

Carbapenem-resistant Enterobacterales, extended-spectrum β-lactamase-producing Enterobacterales, and Pseudomonas aeruginosa with difficult-to-treat resistance have been designated as urgent or serious threats by the Centers for Disease Control and Prevention.

The researchers’ objective was to investigate whether racial/ethnic minority groups, women, and older adults are underrepresented among participants in vaccine clinical trials.

A team of investigators sought to identify patients with undiagnosed acute HIV infection when PrEP/PEP was initiated.

Study authors assessed the noninferiority of posaconazole to voriconazole for the primary treatment of invasive aspergillosis.

Because of the high burden of HIV among Black and Hispanic transgender women, a better understanding of the specific barriers to PrEP uptake and adherence in these women is needed, according to the researchers.

Study authors searched medical databases to identify factors that could be detected in the febrile phase associated with progression to severe dengue disease.

Study authors described racial disparities related to the HIV epidemic and compared key findings with the COVID-19 pandemic.

Study authors examined 186,589 patients with an initial positive urine culture and receiving antibiotics to quantify risks and benefits of UTI prophylaxis in older adults.

Study investigators tested N95, 3-ply disposable surgical, 2-ply cotton-polyester, and heavy cotton masks to assess humidity levels and corresponding benefits.

Researchers studied the dynamics of viral shedding in COVID-19 patients who had submitted routine NPS, sputum, or endotracheal aspirates samples.

Investigators will begin an international randomized, controlled Phase 3 clinical trial to assess the safety and efficacy of an investigational long-acting antibody combination for treating patients hospitalized with COVID-19.

Study authors reviewed challenges to COVID-19 access (production, affordability, allocation, and deployment), paths to success, and policy implications.

Researched evaluated the safety and efficacy of azithromycin in patients admitted to the hospital with COVID-19.

Researchers reviewed existing data to determine the contribution of HIV to MDR-TB worldwide, including the patterns of MDR-TB by age and global region and the trends in MDR-TB infection risks.

Study authors evaluated the incidence of VTE and major bleeding in critically ill patients with COVID19, and examined the observational effect of early therapeutic anticoagulation on survival.

Study authors compared the clinical characteristics and outcomes of women with and without COVID-19 who gave birth during the pandemic.