Large Numbers of Negative Trial Results Impede Progress in Critical Care Medicine
Excessive numbers of negative clinical trials — many of which may be false-negative trials — are a major impediment to the advancement of critical care medicine.
All articles by Laurel Ranger
FDA Transparency on Drug Applications
The FDA has the ability within its governing laws to reveal to the public the reasons for its decisions to reject or approve drugs.
Community-Acquired Pneumonia In-Hospital Deaths Are Not Indicative of Lapse in Care
Most deaths related to community-acquired pneumonia that occurred at tertiary-case hospitals were not preventable.
Respiratory Viruses Linked to Treatment Failure in Asthma Exacerbations
Respiratory pathogens were associated with an increased risk for treatment failure in children with asthma exacerbations.
Human Challenge Studies in Infectious Disease: Despite Need for Rigorous Oversight, Studies Are Vital
Barriers to challenge studies include ethical guidelines indicating that the generation of scientific knowledge should never supersede the rights and interests of research subjects.
C-Reactive Protein as a Biomarker for CAP in Bronchiectasis
Although clinical presentation was similar in both community-acquired pneumonia and non-pneumonia exacerbations, CRP, glucose, and leukocytes were higher in the former vs the latter.
HIV Viral Suppression Rates in Psychiatric Inpatients With Comorbid Substance Use Disorders
A substantial proportion of these individuals diagnosed with HIV, psychiatric disorders, and substance use disorders are out of care and urgently require intervention.
Pediatric Pneumonia: Sensitivity of Lung Ultrasound vs Chest Radiography
Lung ultrasound was more effective in diagnosing pediatric community-acquired pneumonia than chest radiography.
Methadone Maintenance Therapy Associated With Greater Access to Physician Care in HCV-Positive Drug Users
The investigators suggest that enrollment in a methadone maintenance therapy program may be helpful in providing access to HCV care in people who inject drugs.
Wide Range of Clinical Manifestations Identified in Chronic Recurrent Multifocal Osteomyelitis
A series of reported cases shows that the range of associated clinical manifestations is heterogeneous in chronic nonbacterial osteomyelitis or chronic recurrent multifocal osteomyelitis.
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