Nicole Fett

All articles by Nicole Fett

Limited cutaneous systemic sclerosis (Scleroderma, CREST syndrome)

Are You Confident of the Diagnosis? What you should be alert for in the history Scleroderma is a broad term used to denote a subset of sclerosing disorders. Scleroderma has been further subclassified into localized scleroderma (morphea), limited cutaneous systemic sclerosis (previously CREST syndrome, standing for calcinosis, Raynaud’s phenomenon, esophageal dysmotility, sclerodactyly, telangiectasias) and diffuse…

Mixed Connective Tissue Disease (Sharp’s disease)

Are You Confident of the Diagnosis? Mixed connective tissue disease (MCTD) is a systemic autoimmune inflammatory disorder characterized by high titer U1-RNP antibodies, and clinical and serological overlap of systemic lupus erythematosus (SLE), systemic sclerosis (SScl), and polymyositis. Since the original description of MCTD in 1972 by Sharp et al, its existence as a discrete…

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