Roy Weiss

All articles by Roy Weiss

Thyroid hormone resistance

Are you sure the patient has thyroid hormone resistance? The diagnosis of thyroid hormone resistant syndromes (THRS) is based on abnormal thyroid hormone (TH) laboratory tests. This class of conditions is due to a defect in TH action (Resistance to thyroid hormone, RTH), T4 transport into the cell (thyroid hormone Cell Transport Defect, THCTD) or…

TSH Resistance

Are you sure the patient has TSH resistance? Diagnosis of patients with classic signs and symptoms of hypothyroidism in whom there is elevated thyroid stimulating hormone (TSH) and low thyroid hormone (TH) levels is relatively straightforward. When serum TSH is mildly elevated and TH levels are normal the diagnosis of resistance to TSH (RTSH) is…

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