Sweta Gupta, Author at Infectious Disease Advisor

Efficacy Evaluation for Initial Maintenance Therapy in Chronic Pulmonary Aspergillosis

By

Sweta Gupta

May 15, 2019

Oral voriconazole may be more effective than oral itraconazole for initial maintenance therapy in patients with chronic pulmonary aspergillosis, according to a study published in Clinical Infectious Diseases.1 Currently, there are 4 oral anti-Aspergillus agents available (itraconazole, voriconazole, posaconazole, and isavuconazole) and while various studies have evaluated treatments for chronic pulmonary aspergillosis with itraconazole and…

HIV/AIDS

Feminizing Hormone Therapy May Reduce PrEP Efficacy

By

Sweta Gupta

May 14, 2019

In transgender women with HIV, feminizing hormone therapy may decrease the efficacy of pre-exposure prophylaxis.

Although sensitivity is an important consideration when deciding among HIV tests, there are other factors to consider, such as test invasiveness, available resources, need for additional studies, and patient adherence.6 Serum- and plasma-based HIV testing is the most invasive and requires the most resources, such as access to a skilled clinician or phlebotomist and access to special equipment (eg, needles, biohazard containers, laboratory). Whole blood testing can be performed by venipuncture or finger-stick. When blood-based tests yield a sufficient specimen sample using venipuncture, additional studies can be undertaken, such as HIV subtyping and assessment for coinfections, including hepatitis or syphilis. In contrast, oral fluid tests do not require special equipment and can be performed in any setting, including at home, providing results in minutes. These tests also eliminate safety and biohazard concerns, such as needlestick injuries and sharps disposal.

Influenza

Identifying Nosocomial Influenza A: Whole-Genome vs Hemagglutinin/Neuraminidase Sequencing

By

Sweta Gupta

May 13, 2019

Whole-genome sequencing was better at identifying nosocomial influenza A outbreak clusters than hemagglutinin (HA)/neuraminidase (NA) gene sequencing.

Respiratory

Significant Risk for Severe TB and CVD in Patients With Comorbid TB/Diabetes

By

Sweta Gupta

May 9, 2019

The majority of cases of diabetes in patients with tuberculosis are diagnosed, but are poorly controlled in 4 TB-endemic countries.

Mycoses

Injection Drug Use May Be an Under-Recognized Risk Factor for Candidemia in Colorado

By

Sweta Gupta

May 8, 2019

Approximately 1 in 10 patients with candidemia had a history of recent injection drug use based on a surveillance program in the Denver metropolitan area.

The Cleveland Clinic notes that 3D printing “gives medical practitioners the ability to provide patients the most advanced care, while simultaneously minimizing the risk of complication in patients that meet specific medical requirements.” Using this technology, medical devices can be matched to exact patient specifications. 3D printing can be used to improve the lives of patients reliant on prosthetic limbs, replace human organ transplants, and speed up surgical procedures. In all its applications, 3D printing is “increasing the attention to detail in patient care.”2

Antibiotics, Antimicrobial Resistance

Extended Antibiotic Use Safe, Effective in Joint Infection After Total Knee Arthroplasty

By

Sweta Gupta

May 6, 2019

In patients with a TKA periprosthetic joint infection who undergo DAIR, the addition of extended treatment with oral antibiotics appears to be safe and efficacious.

Antibiotics, Antimicrobial Resistance

Low-Level Delamanid and Bedaquiline Resistance in Extensively Drug-Resistant TB

By

Sweta Gupta

April 30, 2019

Researchers reported a case of drug resistance against 2 recently approved antitubercular medications: delamanid and bedaquiline.

Hepatitis

No Significant Effect on Maternal/Fetal Bone Mineral Density With Maternal TDF Use

By

Sweta Gupta

April 26, 2019

There was no significant effect of maternal tenofovir use for the prevention of mother-to-child transmission of HBV on bone mineral density in either the mother or child 1 year after delivery.

HIV/AIDS

ART Interruption With Close Monitoring, Strict Restart Guidelines Safe in HIV Cure Trials

By

Sweta Gupta

April 24, 2019

Analytical treatment interruption caused neither expansion of HIV reservoirs nor immunologic abnormalities after reinitiation of antiretroviral therapy.

Pediatric Illnesses

Pertussis-Related Infant Mortality Rate in Argentina Decreased After Maternal Tdap Vaccination

By

Sweta Gupta

April 19, 2019

Tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine is effective in middle-income countries like Argentina.

Sweta Gupta

All articles by Sweta Gupta

Efficacy Evaluation for Initial Maintenance Therapy in Chronic Pulmonary Aspergillosis

Feminizing Hormone Therapy May Reduce PrEP Efficacy

Identifying Nosocomial Influenza A: Whole-Genome vs Hemagglutinin/Neuraminidase Sequencing

Significant Risk for Severe TB and CVD in Patients With Comorbid TB/Diabetes

Injection Drug Use May Be an Under-Recognized Risk Factor for Candidemia in Colorado

Extended Antibiotic Use Safe, Effective in Joint Infection After Total Knee Arthroplasty

Low-Level Delamanid and Bedaquiline Resistance in Extensively Drug-Resistant TB

No Significant Effect on Maternal/Fetal Bone Mineral Density With Maternal TDF Use

ART Interruption With Close Monitoring, Strict Restart Guidelines Safe in HIV Cure Trials

Pertussis-Related Infant Mortality Rate in Argentina Decreased After Maternal Tdap Vaccination

Risk Factors for Infant Intussusception After Introduction of Rotavirus Vaccine