The American College of Physicians does not recommend chloroquine or hydroxychloroquine, with or without azithromycin, as prophylaxis against or as treatment for COVID-19.
All articles by Sweta Gupta
Respiratory viral coinfection occurs substantially more frequently in children, especially in those aged <5 years.
A team of investigators from the Cleveland Clinic developed a prospective registry of all patients tested for COVID-19 in their health system that was used to validate a model to predict the risk of an individual having a positive COVID-19 test result.
A study revealed that primary care clinicians do not closely follow clinical practice guidelines with regard to antibiotic prescribing for acute sinusitis and frequently overprescribe antibiotics.
Researchers conducted a systematic review and meta-analysis to assess outcomes associated with ongoing antibiotic prophylaxis vs discontinuation following surgery.
Preliminary data demonstrated that the Unyvero HPN panel was strongly concordant with bacterial culture for organism targets, confirming all pathogens reported by culture in 31 out of 35 patient samples.
Reporting the number of excess deaths associated with COVID-19 may help to provide a more accurate accounting of the effect of the pandemic.
An interactive, in-person barrier identification and mitigation tool can ensure safe administration of home-based outpatient parenteral antimicrobial therapy.
Initiation of dolutegravir-based antiretroviral therapy in the third trimester of pregnancy was associated with a greater number of women having a viral load <50 copies/mL at the time of delivery as compared with efavirenz-based therapy.
The uptake rate of pre-exposure prophylaxis (PrEP) for HIV prevention has remained low, especially among at-risk adolescents.
IDSA has outlined several recommendations aimed at reducing the risk forunintended consequences of the Severe Sepsis and Septic Shock Early Management Bundle.
Publication of the revised clinical practice guidelines for Clostridioides difficile infection was followed by significant increases in use of oral vancomycin and fidaxomicin, and a significant decrease in use of oral metronidazole.
Pediatric HIV infection and HIV exposure without infection both had an association with carriage prevalence and densities for Streptococcus pneumoniae and Pneumocystis jirovecii.
Higher levels of C reactive protein (CRP) may be a predictive marker in determining which patients with mild coronavirus disease 2019 (COVID-19) will progress to a severe case.
Correlation between successful isolation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in cell culture and cycle threshold (Ct) value may inform when patients can be safely discharged.
Onset of dyspnea, particularly with precipitous drops in oxygen saturation especially with exertion, can help clinicians to more easily distinguish coronavirus disease 2019 (COVID-19) from other common and treatable illnesses.
Although COVID-19 is commonly mild with the majority of children requiring only supportive care as the primary management strategy, for children who develop severe or critical disease, decision-making regarding antiviral therapy should weigh individual risks and benefits.
As a result of a decline in healthcare–associated infections, the estimated burden of Clostridioides difficile infection in the United States decreased by an adjusted 24% from 2011 through 2017.
Linezolid use in combination therapy is effective and as safe as other firstline treatments for moderate to severe nocardiosis.
In parallel to the ongoing national opioid crisis, the incidence rate of infective endocarditis cases has increased markedly among people aged 18 to 29 years with hepatitis C virus infection and those with opioid use disorder.
Unrecognized asymptomatic and presymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections might contribute to transmission in long-term care facilities.
Nasopharyngeal swab tests may not be sensitive for coronavirus disease 2019 (COVID-19) at early stages of the clinical presentation.
Although tenofovir alafenamide coformulated with emtricitabine has a marginally more benign side effect profile compared with tenofovir disoproxil fumarate coformulated with emtricitabine the additional cost of the newer HIV PrEP is not justifiable.
The United States Preventive Services Task Force now recommends screening for hepatitis C virus infection in all asymptomatic adults.
Hospitalization due to influenza leads to a high likelihood of readmission within 30 days and 1 year with cardiovascular, respiratory, and infectious etiologies being the most common.
Next-generation sequencing is an important tool that can help differentiate HCV reinfection from treatment failure, and may assist with the design of targeted prevention strategies in PWID receiving opioid agonist therapy.
A British man, known as the London patient, may be the second person to be cured of HIV.
A child with intrauterine-acquired HIV who received antiretroviral therapy (ART) at 33 hours after birth through age 13 months showed persistent undetectable HIV viremia more than 3 years after discontinuing ART.
Therapy with monthly injection of long-acting cabotegravir plus rilpivirine was noninferior to once-daily oral therapy for maintaining HIV-1 suppression.