Bacterial Infections

Treatment Algorithm Noninferior to Standard Practice for Staphylococcal Bacteremia

Treatment Algorithm Noninferior to Standard Practice for Staphylococcal Bacteremia

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An algorithm to guide testing and treatment vs standard care protocols in patients with staphylococcal bacteremia was noninferior in clinical success.

Hands Are Vehicles for Transmission of <i>Streptococcus pneumoniae</i>

Hands Are Vehicles for Transmission of Streptococcus pneumoniae

Hands can be vehicles for transmission of pneumococcus and lead to acquisition of nasopharyngeal colonization.

Gentamicin Not Linked to Acute Kidney Injury in Patients with Bacteremia

Gentamicin Not Linked to Acute Kidney Injury in Patients with Bacteremia

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Short course gentamicin therapy in patients with bacteremia was not associated with an increased incidence of acute kidney injury.

IDSA/ATS CAP Guidelines Have Poor Specificity/Sensitivity for Some Bacteria

IDSA/ATS CAP Guidelines Have Poor Specificity/Sensitivity for Some Bacteria

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Recommended indications for Streptococcus pneumoniae and Legionella pneumophila antigen testing for CAP have poor sensitivity and specificity for identifying patients to screen.

TOL-463 Effective for Bacterial Vaginosis and Vulvovaginal Candidiasis

TOL-463 Effective for Bacterial Vaginosis and Vulvovaginal Candidiasis

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TOL-463, particularly in vaginal insert form, is effective and safe in treating bacterial vaginosis and vulvovaginal candidiasis.

Prehospital Advanced Life Support Shortens Antibiotic Wait Times in Sepsis

Prehospital Advanced Life Support Shortens Antibiotic Wait Times in Sepsis

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Antibiotic treatment started sooner in individuals with sepsis treated with advanced life support who did not have hypotension.

A Model to Predict Mortality and Disease Outcomes in C difficile Infection

A Model to Predict Mortality and Disease Outcomes in C difficile Infection

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This study presents a simple, widely available and inexpensive model for predicting C difficile infection severity and mortality to identify patients at risk at admission to the ED.

Local Gentamicin Application Ineffective in Treatment of Periprosthetic Joint Infection

Local Gentamicin Application Ineffective in Treatment of Periprosthetic Joint Infection

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The use of gentamicin-impregnated beads and/or sponges should be discouraged in early acute periprosthetic joint infection as their use is associated with high failure rates.

Low Risk for Bacterial Coinfections in Febrile Infants With Viral Infections

Low Risk for Bacterial Coinfections in Febrile Infants With Viral Infections

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Infants ≤60 days old with fever and confirmed viral infections are at a lower risk for serious bacterial infections compared to infants without a virus.

New Data Suggests Change in Daptomycin Breakpoint for Enterococcal Bacteremia

New Data Suggests Change in Daptomycin Breakpoint for Enterococcal Bacteremia

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A ratio of free drug area under the concentration-time curve to MIC for daptomycin was linked with an higher 30-day survival in some with bacteremia.

Levofloxacin Prophylaxis Decreases Bacteremia in Children With Acute Leukemia

Levofloxacin Prophylaxis Decreases Bacteremia in Children With Acute Leukemia

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Among children with acute leukemia receiving intensive chemotherapy, receipt of levofloxacin prophylaxis compared with no prophylaxis resulted in a significant reduction in bacteremia.

Eravacycline Now Available for Treating Complicated Intra-Abdominal Infections

Eravacycline Now Available for Treating Complicated Intra-Abdominal Infections

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As Xerava is a fully-synthetic fluorocycline antibacterial that is structurally similar to tetracyclines, treatment is contraindicated in patients with known hypersensitivity to tetracycline-class antibacterial drugs.

Patient Develops Glandular Tularemia After Taking Care of Sick Cat

Patient Develops Glandular Tularemia After Taking Care of Sick Cat

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The 68-year-old patient reported having a fever for 1 week followed by progressive, painful swelling on the right side of his neck for 2 months.

Daptomycin Plus Fosfomycin More Effective Than Daptomycin Monotherapy in MRSA Bacteremia

Daptomycin Plus Fosfomycin More Effective Than Daptomycin Monotherapy in MRSA Bacteremia

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The combination of daptomycin with fosfomycin demonstrates increased efficacy in treating methicillin-resistant Staphylococcus aureus bacteremia compared with daptomycin alone.

Oral Ciprofloxacin Effective in Treatment for Bacteremia

Oral Ciprofloxacin Effective in Treatment for Bacteremia

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Oral ciprofloxacin has been found to be an effective option for gram-negative bacteremia treatment.

High-Touch Surfaces at Airports Often Covered in Pathogens

High-Touch Surfaces at Airports Often Covered in Pathogens

At least one respiratory virus detected in 10 percent of surface samples at major airport during flu season.

Time to Blood Culture Positivity Predictive of Mortality in <i> S Aureus </i> Infective Endocarditis

Time to Blood Culture Positivity Predictive of Mortality in S Aureus Infective Endocarditis

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Time to blood culture positivity (TTP) provided reliable information on the risk for infective endocarditis (IE) in patients with Staphylococcus aureus bacteraemia.

Tobramycin Efficacy Decreased by Human Airway Mucus

Tobramycin Efficacy Decreased by Human Airway Mucus

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Human airway mucus alters the susceptibility of Pseudomonas aeruginosa biofilms to tobramycin, but not colistin.

<i>Salmonella</i> Spurs Recall of Swiss Rolls, Bread

Salmonella Spurs Recall of Swiss Rolls, Bread

No illnesses have been reported in connection with the recalled rolls and bread to date.

100 Now Sickened by Salmonella-Tainted Honey Smacks Cereal

100 Now Sickened by Salmonella-Tainted Honey Smacks Cereal

One hundred people across 33 states have now fallen ill with Salmonella after eating Kellogg's Honey Smacks cereal.

Is Short-Course Antibiotic Treatment for CAP Effective?

Is Short-Course Antibiotic Treatment for CAP Effective?

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To investigate what impact antibiotic treatment duration has on CAP outcomes, researchers from the Warren Alpert Medical School of Brown University conducted a search of various databases for studies comparing the safety and efficacy of treatment regimens lasting ≤6 days (short) and ≥7 days (long).

FDA to Review Aemcolo for Treatment of Travelers' Diarrhea

FDA to Review Aemcolo for Treatment of Travelers' Diarrhea

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A Phase 3 clinical trial of patients with travelers' diarrhea demonstrated that Aemcolo was superior to placebo (P=.0008) and non-inferior to ciprofloxacin.

FDA Allows Marketing of Automated Antibiotic Sensitivity Test for Bacteremia

FDA Allows Marketing of Automated Antibiotic Sensitivity Test for Bacteremia

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The US FDA is now allowing marketing of new automated test to identify organisms that cause bacermia and provide antibiotic sensitivity results.

Burden of Osteoarticular Infections Increased by β-Hemolytic Streptococi

Burden of Osteoarticular Infections Increased by β-Hemolytic Streptococi

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Patients 67 years and older were more likely to be affected by group B streptococci or group C and G streptococci strains.

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