Bacterial Infections

Stethoscope Cleaning Standards May Not Eliminate Bacterial Contamination

Stethoscope Cleaning Standards May Not Eliminate Bacterial Contamination

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In-hospital stethoscope cleaning practices may only be partially effective at eliminating bacterial DNA.

Cefiderocol for the Treatment of Complicated Gram-Negative UTIs

Cefiderocol for the Treatment of Complicated Gram-Negative UTIs

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For the treatment of complicated UTI in people with MDR gram-negative infections, treatment with cefiderocol may be noninferior to imipenem cilastatin.

Predicative Factors for Relapse in Adult Bacterial Osteomyelitis

Predicative Factors for Relapse in Adult Bacterial Osteomyelitis

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Several factors for osteomyelitis relapse, including osteomyelitis extending for more than 3 months.

Shorter Antibiotic Course Noninferior for Gram-Negative Bacteremia

Shorter Antibiotic Course Noninferior for Gram-Negative Bacteremia

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A 7-day antibiotic course has demonstrated noninferiority compared with a 14-day course in treating uncomplicated gram-negative bacteremia.

i-STAT Technology May Improve Detection of <i>Burkholderia pseudomallei</i>

i-STAT Technology May Improve Detection of Burkholderia pseudomallei

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The i-STAT assay may detect the Burkholderia pseudomallei capsule and the purified anticapsular polysaccharide more accurately than standard methods.

Limited Examination Detects Scabies With High Sensitivity

Limited Examination Detects Scabies With High Sensitivity

Sensitivity of limited examination is 90%, regardless of scabies severity, presence of impetigo.

Broad-Spectrum Antimicrobial Combination for Corneal Infection Treatment

Broad-Spectrum Antimicrobial Combination for Corneal Infection Treatment

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Combination polymyxin B/trimethoprim ophthalmic formulation containing rifampicin may represent a new agent for the treatment of bacterial keratitis.

Risk Stratification of Febrile Infants Without Routine Lumbar Puncture

Risk Stratification of Febrile Infants Without Routine Lumbar Puncture

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A modified Philadelphia criterion for risk stratification of febrile infants with invasive bacterial infection had high sensitivity without CSF testing.

Pyrosequencing Detects Tuberculosis Drug Resistance and Improves Management

Pyrosequencing Detects Tuberculosis Drug Resistance and Improves Management

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Pyrosequencing may benefit clinical decision making and reduce time to start of effective treatment in patients with drug-resistant tuberculosis.

GI Microbiota and Carbapenem-Resistant Pseudomonas aeruginosa Colonization Risk

GI Microbiota and Carbapenem-Resistant Pseudomonas aeruginosa Colonization Risk

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Decreases in abundance of several taxa may be linked to increased risk for carbapenem-resistant P aeruginosa colonization-acquisition ICU patients.

Head or Spine Surgery Increased Risk for <i>Streptococcus pneumoniae</i> Meningitis

Head or Spine Surgery Increased Risk for Streptococcus pneumoniae Meningitis

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Prior head or spine surgery was associated with increased risk for Streptococcus pneumoniae meningitis outside of the postoperative period.

Unnecessary Antibiotic Use Linked to Lack of Testing and Unspecified Diagnosis

Unnecessary Antibiotic Use Linked to Lack of Testing and Unspecified Diagnosis

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The unnecessary use of antibiotics is associated with an unspecified diagnosis and a lack of microbial testing.

Drug Use-Associated Infective Endocarditis: An Emerging Public Health Issue

Drug Use-Associated Infective Endocarditis: An Emerging Public Health Issue

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There has been a marked increase in the rates of overall hospitalizations and hospital stays that include surgery for drug use-associated infective endocarditis.

Pneumococcal Vaccine May Reduce Resistant <i>Streptococcus Pneumoniae</i> Carriage

Pneumococcal Vaccine May Reduce Resistant Streptococcus Pneumoniae Carriage

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A marked and rapid reduction in PCV13 serotype, the most common antibiotic-nonsusceptible S pneumoniae, carriage was observed in both ethnic populations included in this study.

In Vivo Activity of Cefiderocol Against Resistant Gram-Negative Bacteria

In Vivo Activity of Cefiderocol Against Resistant Gram-Negative Bacteria

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The activity of siderophore cephalosporin cefiderocol against carbapenem-resistant gram-negative Enterobacteriaceae was determined and published as a brief report.

Procalcitonin-Guided Antibiotic Treatment Lowered Antibiotic Exposure

Procalcitonin-Guided Antibiotic Treatment Lowered Antibiotic Exposure

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Procalcitonin-guided antibiotic management resulted in lower antibiotic exposure while maintaining similar mortality rates in patients with bacteremia.

Stethoscopes in ICU Show High Levels of Bacterial Contamination

Stethoscopes in ICU Show High Levels of Bacterial Contamination

Stethoscopes in the intensive care unit have high levels of bacterial contamination.

<i>Klebsiella pneumoniae</i> With PKS Gene Cluster Increases 30-Day Mortality

Klebsiella pneumoniae With PKS Gene Cluster Increases 30-Day Mortality

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Results showed pks carriage by a causative strain was an independent risk factor for 30-day mortality in patients with K pneumoniae bloodstream infections, especially when accompanied by MDR.

Infections Linked to Increased Later Risk for Mental Disorders

Infections Linked to Increased Later Risk for Mental Disorders

Subsequent risk increased with infections requiring hospitalization, treatment with anti-infective agents.

Novel <i>H pylori</i> Eradication Therapy Effective in Phase 3 Trial

Novel H pylori Eradication Therapy Effective in Phase 3 Trial

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The ERADICATE Hp2 trial enrolled 455 dyspepsia patients at 55 sites across the US and randomized them to receive 4 capsules, 3 times daily, of either Talicia or the active comparator, for 14 days.

Addiction Medicine Consultation Improves Antibiotic Compliance in Patients with Opioid Use Disorders

Addiction Medicine Consultation Improves Antibiotic Compliance in Patients with Opioid Use Disorders

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Patients with opioid use disorders who required hospitalization with lengthy antibiotic therapy had better outcomes with addiction medicine consultation.

FDA: Another <i>E. coli</i> Outbreak Linked to Romaine Lettuce

FDA: Another E. coli Outbreak Linked to Romaine Lettuce

So far, 32 people across 11 states have become sick with E. coli after eating romaine lettuce.

Treatment Algorithm Noninferior to Standard Practice for Staphylococcal Bacteremia

Treatment Algorithm Noninferior to Standard Practice for Staphylococcal Bacteremia

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An algorithm to guide testing and treatment vs standard care protocols in patients with staphylococcal bacteremia was noninferior in clinical success.

Hands Are Vehicles for Transmission of <i>Streptococcus pneumoniae</i>

Hands Are Vehicles for Transmission of Streptococcus pneumoniae

Hands can be vehicles for transmission of pneumococcus and lead to acquisition of nasopharyngeal colonization.

Gentamicin Not Linked to Acute Kidney Injury in Patients with Bacteremia

Gentamicin Not Linked to Acute Kidney Injury in Patients with Bacteremia

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Short course gentamicin therapy in patients with bacteremia was not associated with an increased incidence of acute kidney injury.

IDSA/ATS CAP Guidelines Have Poor Specificity/Sensitivity for Some Bacteria

IDSA/ATS CAP Guidelines Have Poor Specificity/Sensitivity for Some Bacteria

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Recommended indications for Streptococcus pneumoniae and Legionella pneumophila antigen testing for CAP have poor sensitivity and specificity for identifying patients to screen.

TOL-463 Effective for Bacterial Vaginosis and Vulvovaginal Candidiasis

TOL-463 Effective for Bacterial Vaginosis and Vulvovaginal Candidiasis

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TOL-463, particularly in vaginal insert form, is effective and safe in treating bacterial vaginosis and vulvovaginal candidiasis.

Prehospital Advanced Life Support Shortens Antibiotic Wait Times in Sepsis

Prehospital Advanced Life Support Shortens Antibiotic Wait Times in Sepsis

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Antibiotic treatment started sooner in individuals with sepsis treated with advanced life support who did not have hypotension.

A Model to Predict Mortality and Disease Outcomes in C difficile Infection

A Model to Predict Mortality and Disease Outcomes in C difficile Infection

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This study presents a simple, widely available and inexpensive model for predicting C difficile infection severity and mortality to identify patients at risk at admission to the ED.

Local Gentamicin Application Ineffective in Treatment of Periprosthetic Joint Infection

Local Gentamicin Application Ineffective in Treatment of Periprosthetic Joint Infection

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The use of gentamicin-impregnated beads and/or sponges should be discouraged in early acute periprosthetic joint infection as their use is associated with high failure rates.

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