Recommended Indications for PrEP Use

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RECOMMENDED INDICATIONS FOR PrEP USE
Men Who Have Sex with Men (MSM)

•  Adult man

•  Without acute or established HIV infection

•  Any male sex partners in past 6 months¹

•  Not in a monogamous partnership with a recently tested, HIV-negative man

AND at least one of the following

•  Any anal sex without condoms (receptive or insertive) in past 6 months

•  A bacterial STI (syphilis, gonorrhea, chlamydia) diagnosed or reported in past 6 months

Heterosexually Active Men and Women

•  Adult person

•  Without acute or established HIV infection

•  Any sex with opposite sex partners in past 6 months

•  Not in a monogamous partnership with a recently tested, HIV-negative partner

AND at least one of the following

•  Is a man who has sex with both women and men (behaviorally bisexual)²

•  Infrequently uses condoms during sex with ≥1 partners of unknown HIV status who are known to be
at substantial risk of HIV infection (IDU or bisexual male partner)

•  Is in an ongoing sexual relationship with an HIV-positive partner

•  A bacterial STI (syphilis, gonorrhea in women or men) diagnosed or reported in past 6 months

Injection Drug Users

•  Adult person

•  Without acute or established HIV infection

•  Any injection of drugs not prescribed by a clinician in past 6 months

AND at least one of the following

•  Any sharing of injection or drug preparation equipment in past 6 months

•  Risk of sexual acquisition3

NOTES

Key: IDU = injection drug users; STI = sexually transmitted infection

1. If also has sex with women see criteria under “Heterosexually Active Men and Women.”

2. Also evaluate indications for PrEP use by “MSM” criteria.

3. Also evaluate by criteria under “MSM” and “Heterosexually Active Men and Women”.

REFERENCES

Centers for Disease Control and Prevention: US Public Health Service. Preexposure Prophylaxis for the Prevention of HIV Infection in the United States - 2017 Update: A Clinical Practice Guideline. https://www.cdc.gov/hiv/pdf/guidelines/cdc-hiv-prep-guidelines-2017.pdf. Published March 2018. Accessed April 19, 2018.

(Rev. 4/2018)

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