There remains a need for novel therapeutic strategies, such as a low-trehalose diet, for CDI treatment and prevention, and this is a potential area of future clinical investigation. The clinical benefit of such strategies should be proven before wide-scale changes to trehalose use in food manufacturing are undertaken.
For solid organ transplant recipients, Clostridium difficile infection is associated with increased graft loss.
Fidaxomicin demonstrated the strongest evidence for being the most effective treatment in providing a long-term cure for C difficile infection.
Given the impact of postoperative Clostridium difficile infection, a heightened sense of suspicion should be given to symptomatic patients after stoma reversal.
Subgroup analyses of 2 MODIFY trial data confirmed prior C difficile infection (CDI), age ≥65 years, infection with 027/078/244 strain, compromised immunity, and severe CDI are risk factors for recurrent CDI.
FIRVANQ is commercially available in 25 and 50 mg/mL strengths in convenient 150 mL and 300 mL sizes.
Healthcare resource utilization and costs attributable to primary Clostridium difficile infection and recurrent C difficile infection are substantial.
Hospital admissions of patients with Clostridium difficile infection and accompanying acute kidney injury are increasing.
The EXTEND study addresses sustained cure as a primary measure of treatment success in a high-risk patient population, with recurrence monitored up to day 90.
Trehalose has been linked to the growing incidence and severity of healthcare-associated outbreaks caused by Clostridium difficile.
Short-term use of probiotics appears to be safe and effective when used along with antibiotics in patients who are not immunocompromised or severely debilitated.
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