Clostridium Difficile

Feature Article

The Role of Dietary Trehalose in the Clostridium difficile Epidemic

The Role of Dietary Trehalose in the Clostridium difficile Epidemic

There remains a need for novel therapeutic strategies, such as a low-trehalose diet, for CDI treatment and prevention, and this is a potential area of future clinical investigation. The clinical benefit of such strategies should be proven before wide-scale changes to trehalose use in food manufacturing are undertaken.

Latest News

FDA Approves New Treatment for Travelers' Diarrhea

FDA Approves New Treatment for Travelers' Diarrhea

Aemcolo is a broad spectrum, semi-synthetic, orally-administered, minimally-absorbed antibiotic designed to allow for delayed release to the colon.

Clostridioides difficile Infection Increases Likelihood of Non-Home Discharge

Clostridioides difficile Infection Increases Likelihood of Non-Home Discharge

Patients admitted from the community who are hospitalized with Clostridioides (formerly Clostridium) difficile infection were more frequently discharged to a non-home location compared to patients without C difficile infection.

A Model to Predict Mortality and Disease Outcomes in C difficile Infection

A Model to Predict Mortality and Disease Outcomes in C difficile Infection

This study presents a simple, widely available and inexpensive model for predicting C difficile infection severity and mortality to identify patients at risk at admission to the ED.

C difficile Tied to Increased Graft Loss in Solid Organ Recipients

C difficile Tied to Increased Graft Loss in Solid Organ Recipients

For solid organ transplant recipients, Clostridium difficile infection is associated with increased graft loss.

Fidaxomicin Effective for Long-Term Cure of Clostridium difficile

Fidaxomicin Effective for Long-Term Cure of Clostridium difficile

Fidaxomicin demonstrated the strongest evidence for being the most effective treatment in providing a long-term cure for C difficile infection.

C difficile Risk Higher With Stoma Reversal vs Colectomy

C difficile Risk Higher With Stoma Reversal vs Colectomy

Given the impact of postoperative Clostridium difficile infection, a heightened sense of suspicion should be given to symptomatic patients after stoma reversal.

Bezlotoxumab May Reduce Recurrent C difficile Infections in High-Risk Groups

Bezlotoxumab May Reduce Recurrent C difficile Infections in High-Risk Groups

Subgroup analyses of 2 MODIFY trial data confirmed prior C difficile infection (CDI), age ≥65 years, infection with 027/078/244 strain, compromised immunity, and severe CDI are risk factors for recurrent CDI.

Firvanq Availability Replaces Need for Compounded Oral Vancomycin Solution

Firvanq Availability Replaces Need for Compounded Oral Vancomycin Solution

FIRVANQ is commercially available in 25 and 50 mg/mL strengths in convenient 150 mL and 300 mL sizes.

Substantial Economic Burden Attributed to Recurrent Clostridium difficile

Substantial Economic Burden Attributed to Recurrent Clostridium difficile

Healthcare resource utilization and costs attributable to primary Clostridium difficile infection and recurrent C difficile infection are substantial.

C difficile Hospitalizations With Acute Kidney Injury Rising

C difficile Hospitalizations With Acute Kidney Injury Rising

Hospital admissions of patients with Clostridium difficile infection and accompanying acute kidney injury are increasing.

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