Clostridium Difficile

Feature Article

Updated C difficile Infection Clinical Guidance From IDSA/SHEA

Updated C difficile Infection Clinical Guidance From IDSA/SHEA

New guidelines for Clostridium difficile infection call for increased attention to the proper diagnosis and treatment of infectious diseases to guard against the unwarranted use of antibiotic drugs.

Latest News

Substantial Economic Burden Attributed to Recurrent Clostridium difficile

Substantial Economic Burden Attributed to Recurrent Clostridium difficile

Healthcare resource utilization and costs attributable to primary Clostridium difficile infection and recurrent C difficile infection are substantial.

C difficile Hospitalizations With Acute Kidney Injury Rising

C difficile Hospitalizations With Acute Kidney Injury Rising

Hospital admissions of patients with Clostridium difficile infection and accompanying acute kidney injury are increasing.

Extended-Pulsed Fidaxomicin Superior to Vancomycin for Sustained CDI Cure in Elderly

Extended-Pulsed Fidaxomicin Superior to Vancomycin for Sustained CDI Cure in Elderly

The EXTEND study addresses sustained cure as a primary measure of treatment success in a high-risk patient population, with recurrence monitored up to day 90.

Food Additive Linked to Growing Incidence of Clostridium difficile

Food Additive Linked to Growing Incidence of Clostridium difficile

Trehalose has been linked to the growing incidence and severity of healthcare-associated outbreaks caused by Clostridium difficile.

Probiotics Effective for Preventing C difficile-Associated Diarrhea

Probiotics Effective for Preventing C difficile-Associated Diarrhea

Short-term use of probiotics appears to be safe and effective when used along with antibiotics in patients who are not immunocompromised or severely debilitated.

Fecal Microbial Transplantation by Oral Capsule Not Inferior to Colonoscopy Delivery

Fecal Microbial Transplantation by Oral Capsule Not Inferior to Colonoscopy Delivery

A study investigated whether fecal microbiota transplantation delivered via oral capsules was as effective as microbiota delivered via colonoscopy for treating recurrent Clostridium difficile infection.

Prolonged Antibiotic Prophylaxis May Increase CDI Risk After Cardiac Surgery

Prolonged Antibiotic Prophylaxis May Increase CDI Risk After Cardiac Surgery

Readmissions for CDI occurred close to hospital discharge, consistent with the CDC's surveillance study findings.

Rifaximin Resistance to C difficile in Patients With Cirrhosis

Rifaximin Resistance to C difficile in Patients With Cirrhosis

Study found a considerable proportion of CDI cases occurring in cirrhotic patients receiving rifaximin. CDI was mostly due to selection of rifaximin-resistant C difficile strains.

Lower Risk of C Difficile Infection With Tetracycline Use

Lower Risk of C Difficile Infection With Tetracycline Use

Researchers conducted a systemic review and meta-analysis to determine which antibiotics for systemic use were associated with the lowest risk of C difficile infection.

Multiply Recurrent C difficile Infection Rate 4 Times Higher Than CDI

Multiply Recurrent C difficile Infection Rate 4 Times Higher Than CDI

The rate of multiply recurrent Clostridium difficile (mrCDI) was found to be more than 4 times higher than that of original CDI, with important implications for treatment decisions.

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