Cytomegalovirus

Ventriculomegaly, Polymicrogyria Predict Epilepsy Risk Among Pediatric Patients With CMV Infections

Ventriculomegaly, Polymicrogyria Predict Epilepsy Risk Among Pediatric Patients With CMV Infections

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Investigators retrospectively reviewed the patients' medical records and MRI images and assessed the associations between the MRI findings and neurologic outcomes, specifically neurodevelopmental achievement, epilepsy, and sensorineural hearing loss.

Infections Complicating the Use of Monoclonal Antibodies for Malignancy

Infections Complicating the Use of Monoclonal Antibodies for Malignancy

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In this review, David C. Helfgott, MD, editorial advisory board member for Infectious Disease Advisor, focuses on infectious complications from the use of monoclonal antibodies for malignancy.

Risk Factors for Cytomegalovirus Reinfections in Seropositive Women

Risk Factors for Cytomegalovirus Reinfections in Seropositive Women

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Findings provide an alternative explanation for virus acquisition and shedding in seroimumne pregnant women that contrasts with proposed mechanisms that argue that reactivation of persistent infection in seroimmune women leads to infection and virus shedding.

Worse Cognitive Outcomes Associated With CMV Antibodies Following ART for HIV

Worse Cognitive Outcomes Associated With CMV Antibodies Following ART for HIV

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Investigators sought to determine the association between antiretroviral therapy and cytomegalovirus infection in individuals with HIV, as well as the potential impact of both on neurocognitive performance.

Case: Fever, Generalized Weakness One Year After Heart Transplant

Case: Fever, Generalized Weakness One Year After Heart Transplant

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Middle-aged woman who received a heart transplant 1 year ago because of dilated cardiomyopathy now presents with mild fever and generalized weakness.

Postnatal cytomegalovirus infection not linked to impaired motor development

Postnatal cytomegalovirus (pCMV) infection in preterm infants associated with higher gross motor scores at 16 months of life and earlier age of onset of independent walking (AOIW). At 6 years of age, children with a history of pCMV infection had cognitive scores within normal limits for age, although with significantly lower verbal IQ scores compared to their non-infected counterparts.

Prophylactic letermovir significantly reduces cytomegalovirus infection after transplantation

Letermovir prophylaxis significantly decreased the incidence of cytomegalovirus infection through 24 weeks following hematopoietic stem cell transplantation. Letermovir was associated with a significantly lower all-cause mortality compared to placebo and did not demonstrate any serious toxicities.

FDA Approves Letermovir for Treatment and Prevention of CMV

FDA Approves Letermovir for Treatment and Prevention of CMV

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The FDA has approved letermovir for the treatment and prevention of cytomegalovirus.

CMV Infection in Mothers and Infants: Diagnostic and Treatment Challenges

CMV Infection in Mothers and Infants: Diagnostic and Treatment Challenges

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Cytomeglovirus infection is associated with a range of diagnostic and treatment challenges and a relatively high transmission rate from the mother to the fetus.

Letermovir Prevents CMV Infection in Bone Marrow Transplant Recipients

Letermovir Prevents CMV Infection in Bone Marrow Transplant Recipients

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Phase 3 study showed positive results for Merck's letermovir in prevention of CMV infection in adult CMV-seropositive recipients of an allogeneic hematopoietic stem cell transplant.

Is CMV a Major Contributor to Cardiovascular Disease in RA?

Is CMV a Major Contributor to Cardiovascular Disease in RA?

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An expert Q&A with Florian Kern, PhD, deputy director of research at Brighton and Sussex Medical School in the UK, who makes the case that cytomegalovirus is a major driver of cardiovascular disease in patients with rheumatoid arthritis.

CMV Titers Associated With Decrease Survival in Rheumatic Diseases

CMV Titers Associated With Decrease Survival in Rheumatic Diseases

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Mortality in patients with rheumatic disease is associated with high cytomegalovirus titers.

Bronchoalveolar Fluid Viral Load Valuable in Assessing CMV Pneumonia in Immunocompromised Patients

Bronchoalveolar Fluid Viral Load Valuable in Assessing CMV Pneumonia in Immunocompromised Patients

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Identifying optimal bronchoalveolar fluid CMV viral load threshold holds potential for diagnosing CMV pneumonia in immunocompromised patients.

Subclinical CMV Replication Leads to Lower CD4/CD8 Ratio During Suppressive ART

Subclinical CMV Replication Leads to Lower CD4/CD8 Ratio During Suppressive ART

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Subclinical CMV replication during early infection of HIV associated with lower CD4/CD8 ratio during suppressive ART.

Universal Screening for Newborn Congenital CMV Cost-Effective But Concerns Remain

Universal Screening for Newborn Congenital CMV Cost-Effective But Concerns Remain

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While universal screening for congenital CMV is more cost-effective than current standard of care, concerns about CMV screening remain.

Latent CMV Infection Induces Chronic Infection Phenotype in Rheumatoid Arthritis

Latent CMV Infection Induces Chronic Infection Phenotype in Rheumatoid Arthritis

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A latent cytomegalovirus infection causes chronic infection phenotype in CD8+ cells.

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