Dengue Virus

Dengue Vaccine Candidate Gets FDA's Priority Review

Dengue Vaccine Candidate Gets FDA's Priority Review

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Two Phase 3 trials conducted in Asia and Latin America assessed the efficacy of the vaccine in >35,000 individuals aged 2 to 16 years.

Dengue Detection and Preparedness Plan for 2020 Olympic Games in Tokyo

Dengue Detection and Preparedness Plan for 2020 Olympic Games in Tokyo

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The failure mode and effect analysis methodology may facilitate protocols for new control that would benefit dengue detection and assessment for the 2020 Olympics.

Dengue Vaccine Presents Solutions and Backlash in Dengue-Endemic Regions

Dengue Vaccine Presents Solutions and Backlash in Dengue-Endemic Regions

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The principles of "trolleyology" can be used to understand hesitancy among certain individuals to vaccinate against the Dengue virus.

Effect of Dengue Serostatus on Dengue Vaccine Safety and Efficacy

Effect of Dengue Serostatus on Dengue Vaccine Safety and Efficacy

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A tetravalent dengue vaccine protective against severe virologically confirmed dengue and hospitalization because of VCD for 5 years in patients with previous dengue exposure before vaccination.

Vector-Borne Diseases Up More Than 2-Fold From 2004 to 2016

Vector-Borne Diseases Up More Than 2-Fold From 2004 to 2016

Vector-borne diseases represent an increasing problem in the United States, with a more than 2-fold increase in the number of annual reports from 2004 to 2016.

Climate Change: Effects on the Incidence and Distribution of Infectious Diseases

Climate Change: Effects on the Incidence and Distribution of Infectious Diseases

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Without proactive measures and response, the changing climate is projected to continue to adversely affect the global incidence and distribution of infectious diseases and cause 250,000 additional deaths per year between 2030 and 2050.

Rapid Antigen Test Differentiates Zika and Dengue Cases

Rapid Antigen Test Differentiates Zika and Dengue Cases

A rapid immunochromatography approach can differentiate dengue and Zika virus cases

Second Dose of Tetravalent Dengue Vaccine Candidate Shows Enhanced Immunogenicity

Second Dose of Tetravalent Dengue Vaccine Candidate Shows Enhanced Immunogenicity

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A tetravalent dengue vaccine candidate (TDV) was found to be safe and immunogenic in an ongoing phase 2 trial. A second TDV dose induced enhanced immunogenicity against DENV-3 and DENV-4 in children who were seronegative before vaccination, supporting the initiation of phase 3 trial to evaluate the efficacy and safety of TDV given in a 2-dose schedule 3 months apart.

No Elevated Malformations Risk, Low Birth Weight With Maternal Dengue

No Elevated Malformations Risk, Low Birth Weight With Maternal Dengue

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Epidemiological study finds reassuring outcomes for Brazilian babies born to mothers with symptomatic dengue during pregnancy.

No Benefit of Prophylactic Platelet Transfusion for Bleeding Prevention in Dengue

No Benefit of Prophylactic Platelet Transfusion for Bleeding Prevention in Dengue

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A randomized trial found that, compared with supportive care alone, added prophylactic platelet transfusion is not effective in preventing bleeding in patients with dengue and thrombocytopenia, and may also lead to adverse effects.

Dengvaxia Most Effective in High-Transmission Areas

Dengvaxia Most Effective in High-Transmission Areas

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Models predicted dengue vaccine would reduce rates of hospitalization in high-transmission areas but increase rates in lower-transmission areas.

Sensitivity of Commercially Available Dengue Virus PCR Assay Evaluated

Sensitivity of Commercially Available Dengue Virus PCR Assay Evaluated

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Diagnostic sensitivity and specificity were 100% for the quantitative real-time reverse-transcriptase assay.

Exposure to the Dengue Virus May Boost Potency of Zika Infection

Exposure to the Dengue Virus May Boost Potency of Zika Infection

And, an antibody that's effective against dengue may also counter Zika.

Hawaii County Officials Declare State of Emergency Over Dengue Fever

Hawaii County Officials Declare State of Emergency Over Dengue Fever

251 cases of dengue fever confirmed on Hawaii Island; two patients still potentially infectious.

Health Officials in Hawaii Addressing Dengue Outbreak

Health Officials in Hawaii Addressing Dengue Outbreak

Officials with the DOH are recommending applying mosquito repellent containing 20 to 30% DEET, wearing long sleeved shirts and pants, using indoor insecticides, and reducing the amount of mosquitoes by clearing areas with standing water.

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