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MicroRNAs in Infectious Disease: Emerging Clinical Applications

MicroRNAs in Infectious Disease: Emerging Clinical Applications

MicroRNAs are currently under investigation for various clinical applications in infectious disease because of their role in host response to infection and effects on innate and adaptive immune pathways.

Diagnostics

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Prognostic Value of Plasma JC Virus-DNA in Progressive Multifocal Leukoencephalopathy

Prognostic Value of Plasma JC Virus-DNA in Progressive Multifocal Leukoencephalopathy

Polyomavirus JC-DNA assessment in plasma samples might complement progressive multifocal leukoencephalopathy diagnosis, especially when cerebrospinal fluid (CSF) is unavailable or polyomavirus JC-DNA is not detectable in CSF.

ED Screening Using Antigen-Antibody Tests Identify Previously Undiagnosed HIV

ED Screening Using Antigen-Antibody Tests Identify Previously Undiagnosed HIV

A study found that nontargeted screening using antigen-antibody tests identified previously undiagnosed HIV infection at a rate that exceeded the CDC screening threshold by severalfold.

Fighting the Spread of Influenza With Ultraviolet Light

Fighting the Spread of Influenza With Ultraviolet Light

Airborne influenza viruses may be safely and effectively eradicated with continuous low doses of far ultraviolet C light.

Systemic inflammatory response syndrome criteria may be more sensitive than quick sequential organ failure assessment for predicting mortality in patients with suspected infection

The systemic inflammatory response syndrome (SIRS) criteria were poorly specific but more sensitive than quick Sequential Organ Failure Assessment (qSOFA), which supports the use of the SIRS criteria as a screening tool for patients with infection who are in danger of further decline.

Antibody Response Detected From Swabs Predicts Respiratory Viral Infection

Antibody Response Detected From Swabs Predicts Respiratory Viral Infection

A simple diagnostic test aids in the early and accurate detection of respiratory viral infection.

Urinalysis Effective for UTI Diagnosis in Younger Febrile Infants

Urinalysis Effective for UTI Diagnosis in Younger Febrile Infants

For febrile infants age 60 days and younger, urinalysis is highly sensitive and specific for diagnosing UTIs.

FDA Clears Diagnostic Urinary Tract Infection Test Strips

FDA Clears Diagnostic Urinary Tract Infection Test Strips

The Food and Drug Administration has granted clearance for UriVarx urinary tract infection test strips for use in patients with overactive bladder and urinary incontinence.

Urinalysis highly sensitive and specific for UTI in febrile infants

Urinalysis had ≥90% sensitivity and specificity in identifying urinary tract infection (UTI) among infants ≤60 days old with fever, regardless of presence of associated bacteremia. Sensitivity of urinalysis was slightly higher among infants with associated bacteremia compared to those without, however specificity remained constant.

Reducing Surgical Site Infections Using Telehealth Electronic Monitoring

Reducing Surgical Site Infections Using Telehealth Electronic Monitoring

Following vascular reconstruction, patients will receive postdischarge care that includes telehealth electronic monitoring.

Value of Confirmatory Testing of Early Infant Diagnosis for HIV

Value of Confirmatory Testing of Early Infant Diagnosis for HIV

Confirmatory testing is valuable and cost-effective for assessing HIV in infants considering false-positive rates of more than 10% when using nucleic acid amplification testing.

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