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MicroRNAs in Infectious Disease: Emerging Clinical Applications

MicroRNAs in Infectious Disease: Emerging Clinical Applications

MicroRNAs are currently under investigation for various clinical applications in infectious disease because of their role in host response to infection and effects on innate and adaptive immune pathways.

Diagnostics

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Inflammatory Markers in CAP Influenced by Time From Symptom Onset to Presentation

Inflammatory Markers in CAP Influenced by Time From Symptom Onset to Presentation

Differences in serum inflammatory markers may exist between patients with community-acquired pneumonia who present within the first 48 hours of symptom onset vs those who present later.

mRNA Assay Less Sensitive Than DNA Assay for Latent HPV

mRNA Assay Less Sensitive Than DNA Assay for Latent HPV

Based on these data and the potential change in follow-up care, the HPV mRNA assay should not be used for a primary screening tool for cervical cancer.

Comparing Diagnostic Imaging for Community-Acquired Pneumonia

Comparing Diagnostic Imaging for Community-Acquired Pneumonia

Adults with community-acquired pneumonia that is visualized on CT scan but not on concurrent chest radiograph have similar pathogens, disease severity, and outcomes as patients who had pneumonia confirmed via chest radiograph.

Helmintex Egg Isolation Method Highly Sensitive for Diagnosing Schistosomiasis

Helmintex Egg Isolation Method Highly Sensitive for Diagnosing Schistosomiasis

Results provide insights into the deployment of diagnostic tools for efforts to eliminate schistosomiasis in low endemic regions.

Sepsis Calculator Reduces Antibiotic Therapy for Suspected Early-Onset Sepsis

Sepsis Calculator Reduces Antibiotic Therapy for Suspected Early-Onset Sepsis

Implementation of the sepsis calculator in daily clinical decision-making may be feasible in conjunction with existing protocols, with high adherence.

Newer Rapid Influenza Tests Better at Ruling In Influenza

Newer Rapid Influenza Tests Better at Ruling In Influenza

Further research on rapid tests is warranted, as industry-sponsored research tends to favor the industry's product and affects how physicians practice medicine.

T2Candida May Shorten Time to Candida Detection, Species Identification

T2Candida May Shorten Time to Candida Detection, Species Identification

Researchers validated the clinical sensitivity of the T2Candida panel for the diagnosis of bloodstream infections caused by the 5 most common pathogenic Candida species.

Major Advances on Horizon for Tick-Borne Disease Testing

Major Advances on Horizon for Tick-Borne Disease Testing

Prompt diagnosis of tick-borne diseases is essential but testing methods have been imprecise. Learn about some recent testing advances for Lyme disease and other tick-borne illnesses.

FDA Approves Blood Screens for Tickborne Parasite

FDA Approves Blood Screens for Tickborne Parasite

Babesia parasites are transmitted by common deer ticks, with approximately 1000 to 2000 cases reported each year primarily in Northeastern and Midwestern states.

Early diagnosis of HIV infection through analysis of oral fluid [Pre-Clinical]

A novel method - Antibody Detection by Agglutination-PCR (ADAP) - was developed to diagnose HIV in oral fluid samples. ADAP is both highly sensitive and highly specific and may allow noninvasive early diagnosis of HIV in population-based screening efforts.

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