Diagnostics

Delays in Lactate Testing Associated With Delayed Antibiotics, Increased Mortality in Sepsis

Delays in Lactate Testing Associated With Delayed Antibiotics, Increased Mortality in Sepsis

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Delayed lactate measurement is associated with delayed antibiotic administration and increased mortality in patients with increased lactate levels.

Rapid Diagnostics Reduce Time to Optimal Antimicrobial Therapy in Children

Rapid Diagnostics Reduce Time to Optimal Antimicrobial Therapy in Children

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Time to optimal antimicrobial therapy for positive blood cultures was assessed in a pediatric population.

Platform Manufacturing May Speed Pandemic Vaccine Development

Platform Manufacturing May Speed Pandemic Vaccine Development

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With the advent of platform manufacturing technology, vaccines can be developed quickly to stop the spread of outbreaks.

Procalcitonin Is Effective Biomarker for Guiding Antibiotic Treatment in Sepsis

Procalcitonin Is Effective Biomarker for Guiding Antibiotic Treatment in Sepsis

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Researchers conducted a literature review to assess the effectiveness and safety of procalcitonin to guide treatment in patients with known or suspected sepsis.

Predictors of Post-Chikungunya Chronic Polyarthralgia

Predictors of Post-Chikungunya Chronic Polyarthralgia

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Researchers reported on the first outbreak of an Asian lineage of chikungunya virus in Aruba.

Early Flow Cytometry Predictive of Clinical Deterioration in Sepsis

Early Flow Cytometry Predictive of Clinical Deterioration in Sepsis

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Increased circulating immature granulocytes at the acute phase of sepsis are linked to clinical worsening, especially when associated with T-cell lymphopenia.

Simple Blood-Based PCR Test Can Predict Progression to Tuberculosis

Simple Blood-Based PCR Test Can Predict Progression to Tuberculosis

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Study identifies and validates a simple PCR-based test from accessible blood samples that predicts TB in heterogeneous African populations with intermediate to high TB burdens.

Pediatric Pneumonia: Sensitivity of Lung Ultrasound vs Chest Radiography

Pediatric Pneumonia: Sensitivity of Lung Ultrasound vs Chest Radiography

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Lung ultrasound was more effective in diagnosing pediatric community-acquired pneumonia than chest radiography.

Molecular Laboratory Test Can Discriminate Sepsis From Noninfectious SIRS

Molecular Laboratory Test Can Discriminate Sepsis From Noninfectious SIRS

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The SeptiCyteTM LAB may be an effective complementary diagnostic tool to clinical assessment of critically ill adult patients in discriminating between sepsis and noninfectious systemic inflammation syndrome.

New Rabies Test Could Radically Change Testing and Treatment

New Rabies Test Could Radically Change Testing and Treatment

A new rapid rabies test for animals could revolutionize screening and spare humans unnecessary painful treatment.

Screening Blood Donations for Zika Virus Is Costly With Low Yield

Screening Blood Donations for Zika Virus Is Costly With Low Yield

Screening blood donations for Zika virus in the United States is costly with low yield.

Best Diagnosis for Sepsis May Be a 2-Step Approach With qSOFA and SIRS

Best Diagnosis for Sepsis May Be a 2-Step Approach With qSOFA and SIRS

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The association of both criteria (qSOFA and SIRS) could provide a better model to initiate or escalate therapy in patients with sepsis.

Low-Dose CT May Modify Pneumonia Diagnosis in Elderly Patients

Low-Dose CT May Modify Pneumonia Diagnosis in Elderly Patients

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Low-dose computed tomography may assist clinicians in modifying diagnosis of elderly patients who are admitted with suspected pneumonia.

UTICalc: A New Calculator for Estimating the Probability of UTI in Children

UTICalc: A New Calculator for Estimating the Probability of UTI in Children

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The UTICalc calculator can be used to guide testing and treatment in children with suspected urinary tract infection.

Wide Range of Clinical Manifestations Identified in Chronic Recurrent Multifocal Osteomyelitis

Wide Range of Clinical Manifestations Identified in Chronic Recurrent Multifocal Osteomyelitis

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A series of reported cases shows that the range of associated clinical manifestations is heterogeneous in chronic nonbacterial osteomyelitis or chronic recurrent multifocal osteomyelitis.

Curbing Overuse of Blood Cultures in the Emergency Department

Curbing Overuse of Blood Cultures in the Emergency Department

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Training on adherence to guidelines, the development of guidelines specific to the pediatric population, and the employment of tools and techniques to decrease contamination of blood cultures could decrease the overuse of blood cultures.

CDC: Declining Incidence of TB in the United States Remains Inadequate for Elimination

CDC: Declining Incidence of TB in the United States Remains Inadequate for Elimination

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Control of active tuberculosis (TB) and a major effort to decrease latent TB infection are both necessary to reduce morbidity and achieve TB elimination in the United States.

First Test to Identify <i>Candida auris</i> Gets FDA Approval

First Test to Identify Candida auris Gets FDA Approval

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The Bruker Maldi system is already cleared for use in identifying 333 species or species groups, including 424 bacteria and yeast species.

Prediction tool for urinary tract infections in preverbal children

The model developed accurately predicted which patients may need further testing based on clinical variables, and who may need antibiotics therapy based on urine analysis supplement.

Inflammatory Markers in CAP Influenced by Time From Symptom Onset to Presentation

Inflammatory Markers in CAP Influenced by Time From Symptom Onset to Presentation

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Differences in serum inflammatory markers may exist between patients with community-acquired pneumonia who present within the first 48 hours of symptom onset vs those who present later.

mRNA Assay Less Sensitive Than DNA Assay for Latent HPV

mRNA Assay Less Sensitive Than DNA Assay for Latent HPV

Based on these data and the potential change in follow-up care, the HPV mRNA assay should not be used for a primary screening tool for cervical cancer.

Comparing Diagnostic Imaging for Community-Acquired Pneumonia

Comparing Diagnostic Imaging for Community-Acquired Pneumonia

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Adults with community-acquired pneumonia that is visualized on CT scan but not on concurrent chest radiograph have similar pathogens, disease severity, and outcomes as patients who had pneumonia confirmed via chest radiograph.

Helmintex Egg Isolation Method Highly Sensitive for Diagnosing Schistosomiasis

Helmintex Egg Isolation Method Highly Sensitive for Diagnosing Schistosomiasis

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Results provide insights into the deployment of diagnostic tools for efforts to eliminate schistosomiasis in low endemic regions.

Sepsis Calculator Reduces Antibiotic Therapy for Suspected Early-Onset Sepsis

Sepsis Calculator Reduces Antibiotic Therapy for Suspected Early-Onset Sepsis

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Implementation of the sepsis calculator in daily clinical decision-making may be feasible in conjunction with existing protocols, with high adherence.

Newer Rapid Influenza Tests Better at Ruling In Influenza

Newer Rapid Influenza Tests Better at Ruling In Influenza

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Further research on rapid tests is warranted, as industry-sponsored research tends to favor the industry's product and affects how physicians practice medicine.

Major Advances on Horizon for Tick-Borne Disease Testing

Major Advances on Horizon for Tick-Borne Disease Testing

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Prompt diagnosis of tick-borne diseases is essential but testing methods have been imprecise. Learn about some recent testing advances for Lyme disease and other tick-borne illnesses.

T2Candida May Shorten Time to <i>Candida</i> Detection, Species Identification

T2Candida May Shorten Time to Candida Detection, Species Identification

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Researchers validated the clinical sensitivity of the T2Candida panel for the diagnosis of bloodstream infections caused by the 5 most common pathogenic Candida species.

FDA Approves Blood Screens for Tickborne Parasite

FDA Approves Blood Screens for Tickborne Parasite

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Babesia parasites are transmitted by common deer ticks, with approximately 1000 to 2000 cases reported each year primarily in Northeastern and Midwestern states.

Early diagnosis of HIV infection through analysis of oral fluid [Pre-Clinical]

A novel method - Antibody Detection by Agglutination-PCR (ADAP) - was developed to diagnose HIV in oral fluid samples. ADAP is both highly sensitive and highly specific and may allow noninvasive early diagnosis of HIV in population-based screening efforts.

Older Hospitalized Adults Tested for Influenza Less Often

Older Hospitalized Adults Tested for Influenza Less Often

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Adults aged 65 and older hospitalized with fever or respiratory symptoms during influenza season are less likely to undergo a provider-ordered influenza test than younger adults.

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