Indications for: ACCOLATE

Prophylaxis and chronic treatment of asthma.

Adults and Children:

Take 1hr before or 2hrs after meals. <5yrs: not established. 5–11yrs: 10mg twice daily.

ACCOLATE Warnings/Precautions:

Not for primary treatment of acute attack. Discontinue if clinical symptoms of liver dysfunction occur; do not resume if confirmed by lab results. Caution when withdrawing from oral steroids. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.

ACCOLATE Classification:

Leukotriene receptor antagonist.

ACCOLATE Interactions:

Potentiates warfarin (monitor PT and adjust warfarin dose). Caution with drugs metabolized by CYP2C9 (eg, tolbutamide, phenytoin, carbamazepine) or CYP3A4 (eg, dihydropyridine calcium channel blockers, cyclosporine, cisapride). Zafirlukast plasma levels reduced by erythromycin, theophylline. Zafirlukast plasma levels increased by aspirin. May increase theophylline levels.

Adverse Reactions:

Headache, infection, GI upset, pain, fever; neuropsychiatric events (eg, insomnia, depression); rarely, hepatic dysfunction (esp. in females), agranulocytosis.

How Supplied:


Pricing for ACCOLATE

20mg tablet (Qty: 60)
Appx. price $44