Inborn errors of metabolism:

Indications for: AMVUTTRA

Polyneuropathy of hereditary transthyretin-mediated amyloidosis.

Adult Dosage:

Give by SC inj in abdomen, thighs, or upper arms. 25mg once every 3 months.

Children Dosage:

Not established.

AMVUTTRA Warnings/Precautions:

Supplement with recommended daily Vit. A allowance. Refer for eye exam if ocular symptoms of Vit. A deficiency occur (eg, night blindness). Moderate or severe hepatic impairment, severe renal impairment, or ESRD: not studied. Elderly. Pregnancy. Nursing mothers.

AMVUTTRA Classification:

Transthyretin-directed small interfering RNA.

Adverse Reactions:

Arthralgia, dyspnea, Vit. A decreased; inj site reactions, AV heart block.

Generic Drug Availability:

NO

How Supplied:

Single-dose prefilled syringe—1

Pricing for AMVUTTRA

0.5ml prefilled syringe of 25mg/0.5ml carton (Qty: 1)
Appx. price $114302
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