Indications for Cefoxitin Injection:
Susceptible bacterial septicemia, lower respiratory or urinary tract, skin and skin structure, bone and joint, gynecologic, intraabdominal infections. Surgical prophylaxis.
Usually 1–2g every 6–8hrs. Uncomplicated: 1g every 6–8hrs. Moderately severe to severe: 1g every 4hrs or 2g every 6–8hrs. Max 2g every 4hrs or 3g every 6hrs. Prophylaxis: see literature.
<3months: not recommended. ≥3months: 80–160mg/kg per day in 4–6 equal divided doses; max 12g/day. Prophylaxis: see literature.
Penicillin or other allergy. Renal impairment (CrCl <50mL/min), reduce dose: see literature. GI disease (esp. colitis). Pregnancy (Cat.B). Nursing mothers.
Aminoglycosides may potentiate nephrotoxicity. Potentiated by probenecid. May cause false (+) Clinitest. May interfere with creatinine tests.
Local reactions, rash, pruritus, drug fever, GI upset, anaphylaxis, blood dyscrasias, elevated liver enzymes.
Formerly known under the brand name Mefoxin.