Viral infections:

Indications for CRIXIVAN:

HIV-1 infection.

Adult Dosage:

Take with water on an empty stomach or with a light meal. 800mg every 8hrs. Concomitant rifabutin: 1g every 8hrs; reduce rifabutin dose by ½. Hepatic insufficiency, or concomitant ketoconazole, itraconazole or delavirdine: 600mg every 8hrs.

Children Dosage:

Not established. 3–18yrs: doses of 500mg/m2 every 8hrs have been used; see full labeling.

CRIXIVAN Contraindications:

Concomitant alfuzosin, amiodarone, lurasidone, pimozide, ergots, cisapride, lovastatin, simvastatin, sildenafil (for PAH), oral midazolam, triazolam, alprazolam.

CRIXIVAN Warnings/Precautions:

Maintain adequate hydration. Discontinue or suspend therapy during acute nephro- or urolithiasis. Risk of acute hemolytic anemia; discontinue if occurs. Hepatic impairment. Monitor for hyperglycemia. Diabetes. Hemophilia (monitor for spontaneous bleeding). Asymptomatic severe leukocyturia: monitor urinalyses. Children (increased risk of nephro- or urolithiasis). Elderly. Pregnancy (Cat.C), nursing mothers: not recommended.

CRIXIVAN Classification:

HIV-1 protease inhibitor.

CRIXIVAN Interactions:

See Contraindications. Rifampin, St. John's wort, atazanavir, salmeterol, fluticasone (w. concomitant potent CYP3A4 inhibitor): not recommended. Caution with atorvastatin and rosuvastatin; titrate, use lowest necessary dose and monitor. Potentiates PDE5 inhibitors, IV midazolam, trazodone, bosentan (reduce doses; see full labeling); antiarrhythmics, rifabutin, calcium channel blockers, clarithromycin, immunosuppressants, others metabolized by CYP3A4. Plasma levels increased by itraconazole, ketoconazole, delavirdine, CYP3A4 inhibitors. Plasma levels reduced by efavirenz, rifabutin, venlafaxine, phenobarbital, phenytoin, carbamazepine, other CYP3A4 inducers. Avoid concomitant colchicine in renal or hepatic impairment; otherwise: reduce dose: see full labeling. Separate dosing of indinavir and didanosine by at least 1hr and give both on empty stomach.

Adverse Reactions:

Nephro- or urolithiasis, asymptomatic hyperbilirubinemia, tubulointerstitial nephritis, abdominal pain, nausea, vomiting, headache, back pain, pruritus, increased cholesterol, hepatitis, hyperglycemia, fat redistribution, renal failure, immune reconstitution syndrome.


Register pregnant patients exposed to indinavir by calling (800) 258-4263.

How Supplied:


Pricing for CRIXIVAN

400mg capsule (Qty: 180)
Appx. price $476