Indications for Doxycycline Monohydrate Tablets:
Tetracycline-susceptible infections including respiratory, genitourinary, rickettsial, trachoma. Postexposure prophylaxis and treatment of anthrax.
Usual dose: 200mg on first day (give as 100mg every 12hrs or 50mg every 6hrs) followed by maintenance dose of 100mg/day (may be given as a single dose or as 50mg every 12hrs). Management of severe infections (including chronic UTI): 100mg every 12hrs. Uncomplicated gonoccal infections (except anorectal infections in men): 100mg twice daily for 7 days or 300mg stat followed in one hour by a second 300mg dose. Acute epididymo-orchitis caused by N. gonorrhoeae, C. trachomatis: 100mg twice daily for at least 10 days. Primary and secondary syphilis: 300mg in divided doses for at least 10 days. Uncomplicated urethral, endocervical, or rectal infection caused by C. trachomatis, nongonococcal urethritis caused by C. trachomatis and U. urealyticum: 100mg twice daily for at least 7 days. Inhalational anthrax (post-exposure): 100mg twice daily for 60 days.
<8yrs: not recommended. >8yrs: ≤100lbs: 2mg/lb divided into two doses on the first day, followed by 1mg/lb as a single daily dose or divided into two doses, on subsequent days. Severe infections: up to 2mg/lb may be used. >100lbs: use adult dose. Inhalational anthrax (post-exposure): ≤100lbs: 1mg/lb twice daily for 60 days. >100lbs: use adult dose.
Doxycycline Monohydrate Tablets Warnings/Precautions:
Monitor blood, renal, and liver function in long-term use. Avoid excessive sunlight or UV light. Pregnancy (Cat.D), nursing mothers: not recommended.
Doxycycline Monohydrate Tablets Classification:
Doxycycline Monohydrate Tablets Interactions:
Antacids, iron, zinc, calcium, magnesium reduce absorption. Avoid concomitant penicillin, methoxyflurane. Carbamazepine, phenytoin, barbiturates may decrease effectiveness. Monitor prothrombin time with oral anticoagulants. May decrease effectiveness of oral contraceptives.
Photosensitivity, GI upset, esophageal irritation/ulceration (drink fluids liberally with dose), rash, increased BUN, hypersensitivity reactions, blood dyscrasias; pseudomembranous colitis.
Tabs 50mg—100; 100mg—50, 250